Mismatch Repair Endonuclease PMS2
A MutL protein and component of the DNA MISMATCH REPAIR system. Its ENDONUCLEASE activity introduces SINGLE-STRAND DNA BREAKS which create entry points for EXO1 exonuclease to remove the strand containing the mismatch. It may also function in DNA DAMAGE signaling.
Year introduced: 2017
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Subheadings:
Tree Number(s): D08.811.074.766.250, D08.811.277.040.025.215.250, D08.811.277.352.335.350.600, D12.776.260.540.250
MeSH Unique ID: D000070976
Registry Number: EC 3.6.1.3
Entry Terms:
- PMS2 Protein
- Postmeiotic Segregation Increased-S. cerevisiae-2
- Postmeiotic Segregation Increased S. cerevisiae 2
- PMS1 Homolog 2, Mismatch Repair Protein
- PMS-2 Protein
- PMS 2 Protein
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