Methyl CpG Binding Domain

A protein domain of about 70 amino acids in length that folds into a sandwich structure consisting of a beta sheet, alpha helix, and C-terminal hairpin loop which forms a hydrophobic methylated-DNA binding patch. It binds to methylated CPG ISLANDS in eukaryotes and occurs with other DNA and CHROMATIN binding domains such as AT-HOOK MOTIFS in eukaryotic DNA BINDING PROTEINS.

Year introduced: 2017

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Tree Number(s): G02.111.570.820.709.275.750.438

MeSH Unique ID: D000070593

Entry Terms:

• Methyl CpG DNA Binding Domain

Previous Indexing:

• DNA-Binding Proteins (1993-2016)

See Also:

• DNA Methylation

All MeSH Categories
Phenomena and Processes Category
Chemical Phenomena
Biochemical Phenomena
Molecular Structure
Molecular Conformation
Protein Conformation
Protein Structural Elements
Protein Domains
Methyl CpG Binding Domain