U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Non-syndromic intellectual disability

MedGen UID:
963615
Concept ID:
CN280315
Disease or Syndrome
Synonym: Mental retardation non-syndromic
 
Monarch Initiative: MONDO:0000509

Definition

An intellectual disability that is not part of a larger syndrome. [from MONDO]

Professional guidelines

PubMed

Wang J, Zhang Q, Chen Y, Yu S, Wu X, Bao X, Wen Y
BMC Med Genet 2018 Oct 30;19(1):191. doi: 10.1186/s12881-018-0699-1. PMID: 30376817Free PMC Article

Recent clinical studies

Etiology

Shepherdson JL, Hutchison K, Don DW, McGillivray G, Choi TI, Allan CA, Amor DJ, Banka S, Basel DG, Buch LD, Carere DA, Carroll R, Clayton-Smith J, Crawford A, Dunø M, Faivre L, Gilfillan CP, Gold NB, Gripp KW, Hobson E, Holtz AM, Innes AM, Isidor B, Jackson A, Katsonis P, Amel Riazat Kesh L; Genomics England Research Consortium, Küry S, Lecoquierre F, Lockhart P, Maraval J, Matsumoto N, McCarrier J, McCarthy J, Miyake N, Moey LH, Németh AH, Østergaard E, Patel R, Pope K, Posey JE, Schnur RE, Shaw M, Stolerman E, Taylor JP, Wadman E, Wakeling E, White SM, Wong LC, Lupski JR, Lichtarge O, Corbett MA, Gecz J, Nicolet CM, Farnham PJ, Kim CH, Shinawi M
Am J Hum Genet 2024 Mar 7;111(3):487-508. Epub 2024 Feb 6 doi: 10.1016/j.ajhg.2024.01.007. PMID: 38325380Free PMC Article
Taşkıran EZ, Karaosmanoğlu B, Koşukcu C, Ürel-Demir G, Akgün-Doğan Ö, Şimşek-Kiper PÖ, Alikaşifoğlu M, Boduroğlu K, Utine GE
J Intellect Disabil Res 2021 Jun;65(6):577-588. Epub 2021 Mar 19 doi: 10.1111/jir.12835. PMID: 33739554
Lindholm Carlström E, Halvardson J, Etemadikhah M, Wetterberg L, Gustavson KH, Feuk L
BMC Med Genomics 2019 Nov 6;12(1):156. doi: 10.1186/s12920-019-0606-4. PMID: 31694657Free PMC Article
Wu Y, Zhang H, Liu X, Shi Z, Li H, Wang Z, Jie X, Huang S, Zhang F, Li J, Zhang K, Gao X
Genes Genomics 2019 Jan;41(1):125-131. Epub 2018 Sep 25 doi: 10.1007/s13258-018-0745-6. PMID: 30255221
Moncini S, Castronovo P, Murgia A, Russo S, Bedeschi MF, Lunghi M, Selicorni A, Bonati MT, Riva P, Venturin M
J Hum Genet 2016 Apr;61(4):283-93. Epub 2015 Dec 10 doi: 10.1038/jhg.2015.144. PMID: 26657932

Diagnosis

Li N, Kang H, Zou Y, Liu Z, Deng Y, Wang M, Li L, Qin H, Qiu X, Wang Y, Zhu J, Agostino M, Heng JI, Yu P
Neurogenetics 2023 Oct;24(4):251-262. Epub 2023 Jul 31 doi: 10.1007/s10048-023-00727-7. PMID: 37525067
Taşkıran EZ, Karaosmanoğlu B, Koşukcu C, Ürel-Demir G, Akgün-Doğan Ö, Şimşek-Kiper PÖ, Alikaşifoğlu M, Boduroğlu K, Utine GE
J Intellect Disabil Res 2021 Jun;65(6):577-588. Epub 2021 Mar 19 doi: 10.1111/jir.12835. PMID: 33739554
Lindholm Carlström E, Halvardson J, Etemadikhah M, Wetterberg L, Gustavson KH, Feuk L
BMC Med Genomics 2019 Nov 6;12(1):156. doi: 10.1186/s12920-019-0606-4. PMID: 31694657Free PMC Article
Wu Y, Zhang H, Liu X, Shi Z, Li H, Wang Z, Jie X, Huang S, Zhang F, Li J, Zhang K, Gao X
Genes Genomics 2019 Jan;41(1):125-131. Epub 2018 Sep 25 doi: 10.1007/s13258-018-0745-6. PMID: 30255221
Gieldon L, Mackenroth L, Kahlert AK, Lemke JR, Porrmann J, Schallner J, von der Hagen M, Markus S, Weidensee S, Novotna B, Soerensen C, Klink B, Wagner J, Tzschach A, Jahn A, Kuhlee F, Hackmann K, Schrock E, Di Donato N, Rump A
PLoS One 2018;13(8):e0201041. Epub 2018 Aug 9 doi: 10.1371/journal.pone.0201041. PMID: 30091983Free PMC Article

Therapy

Zhi X, Pu L, Wu B, Cui Y, Yu C, Dong Y, Li D, Cai C
Clin Chim Acta 2022 Jul 1;532:137-144. Epub 2022 Jun 8 doi: 10.1016/j.cca.2022.05.023. PMID: 35690084
Wu Y, Zhang H, Liu X, Shi Z, Li H, Wang Z, Jie X, Huang S, Zhang F, Li J, Zhang K, Gao X
Genes Genomics 2019 Jan;41(1):125-131. Epub 2018 Sep 25 doi: 10.1007/s13258-018-0745-6. PMID: 30255221

Prognosis

Li N, Kang H, Zou Y, Liu Z, Deng Y, Wang M, Li L, Qin H, Qiu X, Wang Y, Zhu J, Agostino M, Heng JI, Yu P
Neurogenetics 2023 Oct;24(4):251-262. Epub 2023 Jul 31 doi: 10.1007/s10048-023-00727-7. PMID: 37525067
Amin M, Vignal C, Eltaraifee E, Mohammed IN, Hamed AAA, Elseed MA, Babai A, Elbadi I, Mustafa D, Abubaker R, Mustafa M, Drunat S, Elsayed LEO, Ahmed AE, Boespflug-Tanguy O, Dorboz I
BMC Med Genomics 2022 Nov 8;15(1):236. doi: 10.1186/s12920-022-01354-1. PMID: 36348459Free PMC Article
Wu Y, Zhang H, Liu X, Shi Z, Li H, Wang Z, Jie X, Huang S, Zhang F, Li J, Zhang K, Gao X
Genes Genomics 2019 Jan;41(1):125-131. Epub 2018 Sep 25 doi: 10.1007/s13258-018-0745-6. PMID: 30255221
Abbasi AA, Blaesius K, Hu H, Latif Z, Picker-Minh S, Khan MN, Farooq S, Khan MA, Kaindl AM
Am J Med Genet B Neuropsychiatr Genet 2017 Dec;174(8):839-845. Epub 2017 Oct 14 doi: 10.1002/ajmg.b.32602. PMID: 29031008
Morgan A, Gandin I, Belcaro C, Palumbo P, Palumbo O, Biamino E, Dal Col V, Laurini E, Pricl S, Bosco P, Carella M, Ferrero GB, Romano C, d'Adamo AP, Faletra F, Vozzi D
Mutat Res 2015 Nov;781:32-6. Epub 2015 Sep 10 doi: 10.1016/j.mrfmmm.2015.09.002. PMID: 26411299

Clinical prediction guides

Gras M, Heide S, Keren B, Valence S, Garel C, Whalen S, Jansen AC, Keymolen K, Stouffs K, Jennesson M, Poirsier C, Lesca G, Depienne C, Nava C, Rastetter A, Curie A, Cuisset L, Des Portes V, Milh M, Charles P, Mignot C, Héron D
J Med Genet 2024 Jan 19;61(2):103-108. doi: 10.1136/jmg-2023-109203. PMID: 37879892
Amin M, Vignal C, Eltaraifee E, Mohammed IN, Hamed AAA, Elseed MA, Babai A, Elbadi I, Mustafa D, Abubaker R, Mustafa M, Drunat S, Elsayed LEO, Ahmed AE, Boespflug-Tanguy O, Dorboz I
BMC Med Genomics 2022 Nov 8;15(1):236. doi: 10.1186/s12920-022-01354-1. PMID: 36348459Free PMC Article
Jackson MR, Loring KE, Homan CC, Thai MH, Määttänen L, Arvio M, Jarvela I, Shaw M, Gardner A, Gecz J, Shoubridge C
Life Sci Alliance 2019 Aug;2(4) Epub 2019 Aug 22 doi: 10.26508/lsa.201900386. PMID: 31439632Free PMC Article
Wu Y, Zhang H, Liu X, Shi Z, Li H, Wang Z, Jie X, Huang S, Zhang F, Li J, Zhang K, Gao X
Genes Genomics 2019 Jan;41(1):125-131. Epub 2018 Sep 25 doi: 10.1007/s13258-018-0745-6. PMID: 30255221
Santos-Cortez RLP, Khan V, Khan FS, Mughal ZU, Chakchouk I, Lee K, Rasheed M, Hamza R, Acharya A, Ullah E, Saqib MAN, Abbe I, Ali G, Hassan MJ, Khan S, Azeem Z, Ullah I, Bamshad MJ, Nickerson DA, Schrauwen I, Ahmad W, Ansar M, Leal SM
Hum Genet 2018 Sep;137(9):735-752. Epub 2018 Aug 22 doi: 10.1007/s00439-018-1928-6. PMID: 30167849Free PMC Article

Recent systematic reviews

Lee S, Rudd S, Gratten J, Visscher PM, Prins JB, Dawson PA
J Neurogenet 2018 Mar;32(1):6-14. Epub 2017 Dec 4 doi: 10.1080/01677063.2017.1404058. PMID: 29199528

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...