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Hyper-IgE syndrome(HIES1)

MedGen UID:
854488
Concept ID:
C3887645
Disease or Syndrome
Synonym: Hyper-IgE recurrent infection syndrome
SNOMED CT: HIE syndrome (50926003); Job syndrome (50926003); Quie-Hill syndrome (50926003); Buckley's syndrome (50926003); Job-Buckley syndrome (50926003); Hyperimmunoglobulin E syndrome (50926003); Job's syndrome (50926003); Recurring cold staphylococcal abscesses (50926003)
 
Monarch Initiative: MONDO:0018037
OMIM®: 102582; 147060
OMIM® Phenotypic series: PS147060
Orphanet: ORPHA331223

Definition

A condition that is characterized by elevated serum IgE, dermatitis, and respiratory infections. [from NCI]

Professional guidelines

PubMed

Wu PC, Dai YX, Li CL, Chen CC, Chang YT, Ma SH
J Dtsch Dermatol Ges 2023 Jan;21(1):7-17. Epub 2023 Jan 19 doi: 10.1111/ddg.14924. PMID: 36657040
Biggs CM, Keles S, Chatila TA
Clin Immunol 2017 Aug;181:75-82. Epub 2017 Jun 15 doi: 10.1016/j.clim.2017.06.003. PMID: 28625885Free PMC Article
Heimall J, Davis J, Shaw PA, Hsu AP, Gu W, Welch P, Holland SM, Freeman AF
Clin Immunol 2011 Apr;139(1):75-84. Epub 2011 Jan 14 doi: 10.1016/j.clim.2011.01.001. PMID: 21288777Free PMC Article

Recent clinical studies

Etiology

Mohammadi T, Azizi G, Rafiemanesh H, Farahani P, Nirouei M, Tavakol M
Clin Exp Med 2023 Dec;23(8):4835-4859. Epub 2023 Nov 4 doi: 10.1007/s10238-023-01228-5. PMID: 37924455
Tsilifis C, Freeman AF, Gennery AR
J Clin Immunol 2021 Jul;41(5):864-880. Epub 2021 May 1 doi: 10.1007/s10875-021-01051-1. PMID: 33932191Free PMC Article
Sherwani P, Bhalla AS, Jana M, Naranje P, Kabra SK, Gupta AK, Kandasamy D
Indian J Pediatr 2020 Oct;87(10):846-849. Epub 2020 May 8 doi: 10.1007/s12098-020-03289-w. PMID: 32385778
Al-Shaikhly T, Ochs HD
Immunol Cell Biol 2019 Apr;97(4):368-379. Epub 2018 Nov 19 doi: 10.1111/imcb.12209. PMID: 30264496
Olbrich P, Freeman AF
Expert Rev Clin Immunol 2018 Dec;14(12):1029-1041. Epub 2018 Oct 25 doi: 10.1080/1744666X.2018.1531704. PMID: 30280610

Diagnosis

Hazime R, Eddehbi FE, El Mojadili S, Lakhouaja N, Souli I, Salami A, M'Raouni B, Brahim I, Oujidi M, Guennouni M, Bousfiha AA, Admou B
Front Immunol 2022;13:982772. Epub 2022 Sep 13 doi: 10.3389/fimmu.2022.982772. PMID: 36177048Free PMC Article
Park B, Liu GY
Int J Mol Sci 2020 Dec 1;21(23) doi: 10.3390/ijms21239152. PMID: 33271763Free PMC Article
Devonshire AL, Makhija M
Allergy Asthma Proc 2019 Nov 1;40(6):465-469. doi: 10.2500/aap.2019.40.4273. PMID: 31690396
Al-Shaikhly T, Ochs HD
Immunol Cell Biol 2019 Apr;97(4):368-379. Epub 2018 Nov 19 doi: 10.1111/imcb.12209. PMID: 30264496
Olbrich P, Freeman AF
Expert Rev Clin Immunol 2018 Dec;14(12):1029-1041. Epub 2018 Oct 25 doi: 10.1080/1744666X.2018.1531704. PMID: 30280610

Therapy

Bardou MLD, Henriques MT, Grumach AS
J Pediatr (Rio J) 2021 Mar-Apr;97 Suppl 1(Suppl 1):S75-S83. Epub 2020 Dec 19 doi: 10.1016/j.jped.2020.10.015. PMID: 33347837Free PMC Article
Dmitrieva NI, Walts AD, Nguyen DP, Grubb A, Zhang X, Wang X, Ping X, Jin H, Yu Z, Yu ZX, Yang D, Schwartzbeck R, Dalgard CL, Kozel BA, Levin MD, Knutsen RH, Liu D, Milner JD, López DB, O'Connell MP, Lee CR, Myles IA, Hsu AP, Freeman AF, Holland SM, Chen G, Boehm M
J Clin Invest 2020 Aug 3;130(8):4167-4181. doi: 10.1172/JCI135490. PMID: 32369445Free PMC Article
Duréault A, Tcherakian C, Poiree S, Catherinot E, Danion F, Jouvion G, Bougnoux ME, Mahlaoui N, Givel C, Castelle M, Picard C, Chansdesris MO, Lortholary O, Lanternier F; French Mycoses Study Group
J Allergy Clin Immunol Pract 2019 Jul-Aug;7(6):1986-1995.e3. Epub 2019 Mar 13 doi: 10.1016/j.jaip.2019.02.041. PMID: 30878710
Olbrich P, Freeman AF
Expert Rev Clin Immunol 2018 Dec;14(12):1029-1041. Epub 2018 Oct 25 doi: 10.1080/1744666X.2018.1531704. PMID: 30280610
Sowerwine KJ, Shaw PA, Gu W, Ling JC, Collins MT, Darnell DN, Anderson VL, Davis J, Hsu A, Welch P, Puck JM, Holland SM, Freeman AF
J Clin Immunol 2014 Feb;34(2):260-4. Epub 2014 Jan 9 doi: 10.1007/s10875-013-9982-2. PMID: 24402620Free PMC Article

Prognosis

Dmitrieva NI, Walts AD, Nguyen DP, Grubb A, Zhang X, Wang X, Ping X, Jin H, Yu Z, Yu ZX, Yang D, Schwartzbeck R, Dalgard CL, Kozel BA, Levin MD, Knutsen RH, Liu D, Milner JD, López DB, O'Connell MP, Lee CR, Myles IA, Hsu AP, Freeman AF, Holland SM, Chen G, Boehm M
J Clin Invest 2020 Aug 3;130(8):4167-4181. doi: 10.1172/JCI135490. PMID: 32369445Free PMC Article
Alyasin S, Esmaeilzadeh H, Ebrahimi N, Nabavizadeh SH, Kashef S, Esmaeilzadeh E, Babaei M, Amin R
Allergol Immunopathol (Madr) 2019 Mar-Apr;47(2):152-158. Epub 2018 Sep 29 doi: 10.1016/j.aller.2018.07.009. PMID: 30279075
Olbrich P, Freeman AF
Expert Rev Clin Immunol 2018 Dec;14(12):1029-1041. Epub 2018 Oct 25 doi: 10.1080/1744666X.2018.1531704. PMID: 30280610
Arkwright PD, Stafford JC, Sharma V
J Allergy Clin Immunol Pract 2014 Jul-Aug;2(4):388-95. Epub 2014 Apr 18 doi: 10.1016/j.jaip.2014.01.016. PMID: 25017525
Yalçin B, Demir HA, Ciftçi AO, Orhan D, Varan A, Akyüz C, Kutluk T, Büyükpamukçu M
J Pediatr Hematol Oncol 2012 Nov;34(8):601-5. doi: 10.1097/MPH.0b013e31825808e9. PMID: 22767129

Clinical prediction guides

Grenier PA, Brun AL, Longchampt E, Lipski M, Mellot F, Catherinot E
Eur Radiol 2024 Jun;34(6):4142-4154. Epub 2023 Nov 8 doi: 10.1007/s00330-023-10334-7. PMID: 37935849Free PMC Article
Takeuchi I, Yanagi K, Takada S, Uchiyama T, Igarashi A, Motomura K, Hayashi Y, Nagano N, Matsuoka R, Sugiyama H, Yoshioka T, Saito H, Kawai T, Miyaji Y, Inuzuka Y, Matsubara Y, Ohya Y, Shimizu T, Matsumoto K, Arai K, Nomura I, Kaname T, Morita H
J Allergy Clin Immunol 2023 May;151(5):1402-1409.e6. Epub 2022 Dec 17 doi: 10.1016/j.jaci.2022.12.802. PMID: 36538978
Dmitrieva NI, Walts AD, Nguyen DP, Grubb A, Zhang X, Wang X, Ping X, Jin H, Yu Z, Yu ZX, Yang D, Schwartzbeck R, Dalgard CL, Kozel BA, Levin MD, Knutsen RH, Liu D, Milner JD, López DB, O'Connell MP, Lee CR, Myles IA, Hsu AP, Freeman AF, Holland SM, Chen G, Boehm M
J Clin Invest 2020 Aug 3;130(8):4167-4181. doi: 10.1172/JCI135490. PMID: 32369445Free PMC Article
Su HC, Jing H, Zhang Q
Ann N Y Acad Sci 2011 Dec;1246:26-33. doi: 10.1111/j.1749-6632.2011.06295.x. PMID: 22236427
Minegishi Y
Curr Opin Immunol 2009 Oct;21(5):487-92. Epub 2009 Aug 28 doi: 10.1016/j.coi.2009.07.013. PMID: 19717292

Recent systematic reviews

Mohammadi T, Azizi G, Rafiemanesh H, Farahani P, Nirouei M, Tavakol M
Clin Exp Med 2023 Dec;23(8):4835-4859. Epub 2023 Nov 4 doi: 10.1007/s10238-023-01228-5. PMID: 37924455
Wu PC, Dai YX, Li CL, Chen CC, Chang YT, Ma SH
J Dtsch Dermatol Ges 2023 Jan;21(1):7-17. Epub 2023 Jan 19 doi: 10.1111/ddg.14924. PMID: 36657040
Delplanque M, Galicier L, Oziol E, Ducharme-Bénard S, Oksenhendler E, Buob D, Grateau G, Boutboul D, Georgin-Lavialle S
J Allergy Clin Immunol Pract 2021 Feb;9(2):745-752.e1. Epub 2020 Sep 30 doi: 10.1016/j.jaip.2020.09.023. PMID: 33007500

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