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Endometrial carcinosarcoma

MedGen UID:
1380289
•Concept ID:
C4517098
•
Neoplastic Process
Synonyms: Carcinosarcoma of endometrium; Malignant mixed Mullerian neoplasm of endometrium; Malignant Mullerian mixed tumor of endometrium
SNOMED CT: Endometrial carcinosarcoma (732201008); Carcinosarcoma of endometrium (732201008); Malignant mixed Mullerian neoplasm of endometrium (732201008); Malignant Mullerian mixed tumor of endometrium (732201008)

Professional guidelines

PubMed

Incorporation of anti-PD1 or anti PD-L1 agents to platinum-based chemotherapy for the primary treatment of advanced or recurrent endometrial cancer. A meta-analysis.
Bartoletti M, Montico M, Lorusso D, Mazzeo R, Oaknin A, Musacchio L, Scambia G, Puglisi F, Pignata S
Cancer Treat Rev 2024 Apr;125:102701. Epub 2024 Feb 27 doi: 10.1016/j.ctrv.2024.102701. PMID: 38422895
Impact of adjuvant treatment on outcome in high-risk early-stage endometrial cancer: a retrospective three-center study.
Helpman L, Perri T, Lavee N, Hag-Yahia N, Chariski HA, Kalfon S, Derazne E, Beiner ME, Kadan Y, Fishman A, Korach J, Covens A, Gien L
Int J Gynecol Cancer 2019 Jan;29(1):133-139. doi: 10.1136/ijgc-2018-000030. PMID: 30640695
Uterine sarcoma-current management and experience from a regional cancer centre in North India.
Biswas A, Patel F, Kumar P, Srinivasan R, Bera A, Sharma SC, Rajwanshi A
Arch Gynecol Obstet 2013 Oct;288(4):873-82. Epub 2013 Apr 12 doi: 10.1007/s00404-013-2843-7. PMID: 23580012

Recent clinical studies

Etiology

Germline drivers of gynecologic carcinosarcomas.
Sia TY, Gordhandas SB, Birsoy O, Kemel Y, Maio A, Salo-Mullen E, Sheehan M, Hensley ML, Rubinstein M, Makker V, Grisham RN, O'Cearbhaill RE, Roche KL, Mueller JJ, Leitao MM Jr, Sonoda Y, Chi DS, Abu-Rustum NR, Berger MF, Ellenson LH, Latham A, Stadler Z, Offit K, Aghajanian C, Weigelt B, Mandelker D, Liu YL
Gynecol Oncol 2023 Jul;174:34-41. Epub 2023 May 5 doi: 10.1016/j.ygyno.2023.04.024. PMID: 37149903Free PMC Article
Comparison of minimally invasive versus open surgery in the treatment of endometrial carcinosarcoma.
Pedra Nobre S, Mueller JJ, Gardner GJ, Long Roche K, Brown CL, Soslow RA, Alektiar KM, Sonoda Y, Broach VA, Jewell EL, Zivanovic O, Chi DS, Abu-Rustum NR, Leitao MM Jr
Int J Gynecol Cancer 2020 Aug;30(8):1162-1168. Epub 2020 Jul 20 doi: 10.1136/ijgc-2020-001573. PMID: 32690592Free PMC Article
Vaginoscopic hysteroscopy in management for women with post-menopausal vaginal bleeding.
Lee YL, Bai YS, Yin CS
Taiwan J Obstet Gynecol 2019 Jul;58(4):497-500. doi: 10.1016/j.tjog.2019.05.012. PMID: 31307740
Second Opinion Expert Pathology in Endometrial Cancer: Potential Clinical Implications.
Grevenkamp F, Kommoss F, Kommoss F, Lax S, Fend F, Wallwiener D, Schönfisch B, Krämer B, Brucker SY, Taran FA, Staebler A, Kommoss S
Int J Gynecol Cancer 2017 Feb;27(2):289-296. doi: 10.1097/IGC.0000000000000870. PMID: 27922981
Can MRI predict the diagnosis of endometrial carcinosarcoma?
Genever AV, Abdi S
Clin Radiol 2011 Jul;66(7):621-4. Epub 2011 Apr 20 doi: 10.1016/j.crad.2011.02.008. PMID: 21507390

Diagnosis

Germline drivers of gynecologic carcinosarcomas.
Sia TY, Gordhandas SB, Birsoy O, Kemel Y, Maio A, Salo-Mullen E, Sheehan M, Hensley ML, Rubinstein M, Makker V, Grisham RN, O'Cearbhaill RE, Roche KL, Mueller JJ, Leitao MM Jr, Sonoda Y, Chi DS, Abu-Rustum NR, Berger MF, Ellenson LH, Latham A, Stadler Z, Offit K, Aghajanian C, Weigelt B, Mandelker D, Liu YL
Gynecol Oncol 2023 Jul;174:34-41. Epub 2023 May 5 doi: 10.1016/j.ygyno.2023.04.024. PMID: 37149903Free PMC Article
Endometrial carcinosarcoma.
Bogani G, Ray-Coquard I, Concin N, Ngoi NYL, Morice P, Caruso G, Enomoto T, Takehara K, Denys H, Lorusso D, Coleman R, Vaughan MM, Takano M, Provencher DM, Sagae S, Wimberger P, Póka R, Segev Y, Kim SI, Kim JW, Candido Dos Reis FJ, Ramirez PT, Mariani A, Leitao M, Makker V, Abu-Rustum NR, Vergote I, Zannoni G, Tan D, McCormack M, Paolini B, Bini M, Raspagliesi F, Benedetti Panici P, Di Donato V, Muzii L, Colombo N, Pignata S, Scambia G, Monk BJ
Int J Gynecol Cancer 2023 Feb 6;33(2):147-174. doi: 10.1136/ijgc-2022-004073. PMID: 36585027
Comparison of minimally invasive versus open surgery in the treatment of endometrial carcinosarcoma.
Pedra Nobre S, Mueller JJ, Gardner GJ, Long Roche K, Brown CL, Soslow RA, Alektiar KM, Sonoda Y, Broach VA, Jewell EL, Zivanovic O, Chi DS, Abu-Rustum NR, Leitao MM Jr
Int J Gynecol Cancer 2020 Aug;30(8):1162-1168. Epub 2020 Jul 20 doi: 10.1136/ijgc-2020-001573. PMID: 32690592Free PMC Article
Second Opinion Expert Pathology in Endometrial Cancer: Potential Clinical Implications.
Grevenkamp F, Kommoss F, Kommoss F, Lax S, Fend F, Wallwiener D, Schönfisch B, Krämer B, Brucker SY, Taran FA, Staebler A, Kommoss S
Int J Gynecol Cancer 2017 Feb;27(2):289-296. doi: 10.1097/IGC.0000000000000870. PMID: 27922981
Can MRI predict the diagnosis of endometrial carcinosarcoma?
Genever AV, Abdi S
Clin Radiol 2011 Jul;66(7):621-4. Epub 2011 Apr 20 doi: 10.1016/j.crad.2011.02.008. PMID: 21507390

Therapy

Incorporation of anti-PD1 or anti PD-L1 agents to platinum-based chemotherapy for the primary treatment of advanced or recurrent endometrial cancer. A meta-analysis.
Bartoletti M, Montico M, Lorusso D, Mazzeo R, Oaknin A, Musacchio L, Scambia G, Puglisi F, Pignata S
Cancer Treat Rev 2024 Apr;125:102701. Epub 2024 Feb 27 doi: 10.1016/j.ctrv.2024.102701. PMID: 38422895
Endometrial carcinosarcoma.
Bogani G, Ray-Coquard I, Concin N, Ngoi NYL, Morice P, Caruso G, Enomoto T, Takehara K, Denys H, Lorusso D, Coleman R, Vaughan MM, Takano M, Provencher DM, Sagae S, Wimberger P, Póka R, Segev Y, Kim SI, Kim JW, Candido Dos Reis FJ, Ramirez PT, Mariani A, Leitao M, Makker V, Abu-Rustum NR, Vergote I, Zannoni G, Tan D, McCormack M, Paolini B, Bini M, Raspagliesi F, Benedetti Panici P, Di Donato V, Muzii L, Colombo N, Pignata S, Scambia G, Monk BJ
Int J Gynecol Cancer 2023 Feb 6;33(2):147-174. doi: 10.1136/ijgc-2022-004073. PMID: 36585027
Durvalumab with or without tremelimumab in patients with persistent or recurrent endometrial cancer or endometrial carcinosarcoma: A randomized open-label phase 2 study.
Rubinstein MM, Doria ER, Konner J, Lichtman S, Zhou Q, Iasonos A, Sarasohn D, Troso-Sandoval T, Friedman C, O'Cearbhaill R, Cadoo K, Kyi C, Cohen S, Soldan K, Billinson E, Caird I, Jang D, Eid K, Shah P, Guillen J, Aghajanian C, Zamarin D, Makker V
Gynecol Oncol 2023 Feb;169:64-69. Epub 2022 Dec 10 doi: 10.1016/j.ygyno.2022.11.028. PMID: 36512912Free PMC Article
Comparison of minimally invasive versus open surgery in the treatment of endometrial carcinosarcoma.
Pedra Nobre S, Mueller JJ, Gardner GJ, Long Roche K, Brown CL, Soslow RA, Alektiar KM, Sonoda Y, Broach VA, Jewell EL, Zivanovic O, Chi DS, Abu-Rustum NR, Leitao MM Jr
Int J Gynecol Cancer 2020 Aug;30(8):1162-1168. Epub 2020 Jul 20 doi: 10.1136/ijgc-2020-001573. PMID: 32690592Free PMC Article
Impact of adjuvant treatment on outcome in high-risk early-stage endometrial cancer: a retrospective three-center study.
Helpman L, Perri T, Lavee N, Hag-Yahia N, Chariski HA, Kalfon S, Derazne E, Beiner ME, Kadan Y, Fishman A, Korach J, Covens A, Gien L
Int J Gynecol Cancer 2019 Jan;29(1):133-139. doi: 10.1136/ijgc-2018-000030. PMID: 30640695

Prognosis

The expression of programmed death-ligand 1 and programmed death-ligand 2 in endometrial carcinosarcoma: Correlation with mismatch repair protein expression status, tumor-infiltrating lymphocyte infiltration, and clinical outcomes.
Atılgan AO, Tepeoğlu M, Özen Ö, Reyhan ANH, Ayhan A
Ann Diagn Pathol 2023 Aug;65:152137. Epub 2023 Apr 9 doi: 10.1016/j.anndiagpath.2023.152137. PMID: 37060883
Mesonephric-like Carcinosarcoma of the Uterine Corpus: Clinicopathological, Molecular and Prognostic Characteristics in Comparison With Uterine Mesonephric-like Adenocarcinoma and Conventional Endometrial Carcinosarcoma.
Park S, Park E, Kim HS
Cancer Genomics Proteomics 2022 Nov-Dec;19(6):747-760. doi: 10.21873/cgp.20357. PMID: 36316041Free PMC Article
Histologic Appearance and Immunohistochemistry of DNA Mismatch Repair Protein and p53 in Endometrial Carcinosarcoma: Impact on Prognosis and Insights Into Tumorigenesis.
Saijo M, Nakamura K, Ida N, Nasu A, Yoshino T, Masuyama H, Yanai H
Am J Surg Pathol 2019 Nov;43(11):1493-1500. doi: 10.1097/PAS.0000000000001353. PMID: 31478942
Vaginoscopic hysteroscopy in management for women with post-menopausal vaginal bleeding.
Lee YL, Bai YS, Yin CS
Taiwan J Obstet Gynecol 2019 Jul;58(4):497-500. doi: 10.1016/j.tjog.2019.05.012. PMID: 31307740
Oncogene alterations in endometrial carcinosarcomas.
Biscuola M, Van de Vijver K, Castilla MÁ, Romero-Pérez L, López-García MÁ, Díaz-Martín J, Matias-Guiu X, Oliva E, Palacios Calvo J
Hum Pathol 2013 May;44(5):852-9. Epub 2012 Nov 28 doi: 10.1016/j.humpath.2012.07.027. PMID: 23199529

Clinical prediction guides

Germline drivers of gynecologic carcinosarcomas.
Sia TY, Gordhandas SB, Birsoy O, Kemel Y, Maio A, Salo-Mullen E, Sheehan M, Hensley ML, Rubinstein M, Makker V, Grisham RN, O'Cearbhaill RE, Roche KL, Mueller JJ, Leitao MM Jr, Sonoda Y, Chi DS, Abu-Rustum NR, Berger MF, Ellenson LH, Latham A, Stadler Z, Offit K, Aghajanian C, Weigelt B, Mandelker D, Liu YL
Gynecol Oncol 2023 Jul;174:34-41. Epub 2023 May 5 doi: 10.1016/j.ygyno.2023.04.024. PMID: 37149903Free PMC Article
The expression of programmed death-ligand 1 and programmed death-ligand 2 in endometrial carcinosarcoma: Correlation with mismatch repair protein expression status, tumor-infiltrating lymphocyte infiltration, and clinical outcomes.
Atılgan AO, Tepeoğlu M, Özen Ö, Reyhan ANH, Ayhan A
Ann Diagn Pathol 2023 Aug;65:152137. Epub 2023 Apr 9 doi: 10.1016/j.anndiagpath.2023.152137. PMID: 37060883
Vaginoscopic hysteroscopy in management for women with post-menopausal vaginal bleeding.
Lee YL, Bai YS, Yin CS
Taiwan J Obstet Gynecol 2019 Jul;58(4):497-500. doi: 10.1016/j.tjog.2019.05.012. PMID: 31307740
Oncogene alterations in endometrial carcinosarcomas.
Biscuola M, Van de Vijver K, Castilla MÁ, Romero-Pérez L, López-García MÁ, Díaz-Martín J, Matias-Guiu X, Oliva E, Palacios Calvo J
Hum Pathol 2013 May;44(5):852-9. Epub 2012 Nov 28 doi: 10.1016/j.humpath.2012.07.027. PMID: 23199529
Can MRI predict the diagnosis of endometrial carcinosarcoma?
Genever AV, Abdi S
Clin Radiol 2011 Jul;66(7):621-4. Epub 2011 Apr 20 doi: 10.1016/j.crad.2011.02.008. PMID: 21507390

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