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Food protein-induced enterocolitis syndrome

MedGen UID:
1623554
•Concept ID:
C4268599
•
Disease or Syndrome
Synonyms: Allergic enterocolitis caused by food protein; delayed food allergy; food protein-induced enterocolitis syndrome; Food-protein induced enterocolitis syndrome; FPIES; FPIES - Food-protein induced enterocolitis syndrome
SNOMED CT: Allergic enterocolitis caused by food protein (737315000); Food-protein induced enterocolitis syndrome (737315000); FPIES - Food-protein induced enterocolitis syndrome (737315000)
 
Monarch Initiative: MONDO:0100008

Definition

An eosinophilic gastrointestinal disorder triggered by food that is non-IgE-mediated. [from MONDO]

Professional guidelines

PubMed

Cow's Milk Protein Allergy in Term and Preterm Infants: Clinical Manifestations, Immunologic Pathophysiology, and Management Strategies.
Burris AD, Burris J, Järvinen KM
Neoreviews 2020 Dec;21(12):e795-e808. doi: 10.1542/neo.21-12-e795. PMID: 33262206
International consensus guidelines for the diagnosis and management of food protein-induced enterocolitis syndrome: Executive summary-Workgroup Report of the Adverse Reactions to Foods Committee, American Academy of Allergy, Asthma & Immunology.
Nowak-Węgrzyn A, Chehade M, Groetch ME, Spergel JM, Wood RA, Allen K, Atkins D, Bahna S, Barad AV, Berin C, Brown Whitehorn T, Burks AW, Caubet JC, Cianferoni A, Conte M, Davis C, Fiocchi A, Grimshaw K, Gupta R, Hofmeister B, Hwang JB, Katz Y, Konstantinou GN, Leonard SA, Lightdale J, McGhee S, Mehr S, Sopo SM, Monti G, Muraro A, Noel SK, Nomura I, Noone S, Sampson HA, Schultz F, Sicherer SH, Thompson CC, Turner PJ, Venter C, Westcott-Chavez AA, Greenhawt M
J Allergy Clin Immunol 2017 Apr;139(4):1111-1126.e4. Epub 2017 Feb 4 doi: 10.1016/j.jaci.2016.12.966. PMID: 28167094
Review article: the diagnosis and management of food allergy and food intolerances.
Turnbull JL, Adams HN, Gorard DA
Aliment Pharmacol Ther 2015 Jan;41(1):3-25. Epub 2014 Oct 14 doi: 10.1111/apt.12984. PMID: 25316115

Recent clinical studies

Etiology

Anaphylaxis: A 2023 practice parameter update.
Golden DBK, Wang J, Waserman S, Akin C, Campbell RL, Ellis AK, Greenhawt M, Lang DM, Ledford DK, Lieberman J, Oppenheimer J, Shaker MS, Wallace DV, Abrams EM, Bernstein JA, Chu DK, Horner CC, Rank MA, Stukus DR; Collaborators, Burrows AG, Cruickshank H; Workgroup Contributors, Golden DBK, Wang J, Akin C, Campbell RL, Ellis AK, Greenhawt M, Lang DM, Ledford DK, Lieberman J, Oppenheimer J, Shaker MS, Wallace DV, Waserman S; Joint Task Force on Practice Parameters Reviewers, Abrams EM, Bernstein JA, Chu DK, Ellis AK, Golden DBK, Greenhawt M, Horner CC, Ledford DK, Lieberman J, Rank MA, Shaker MS, Stukus DR, Wang J
Ann Allergy Asthma Immunol 2024 Feb;132(2):124-176. Epub 2023 Dec 18 doi: 10.1016/j.anai.2023.09.015. PMID: 38108678
Update on Food Protein-Induced Enterocolitis Syndrome (FPIES).
Baker MG, Cecilia Berin M, Sicherer S
Curr Allergy Asthma Rep 2022 Oct;22(10):113-122. Epub 2022 May 6 doi: 10.1007/s11882-022-01037-y. PMID: 35522370
Food Allergy from Infancy Through Adulthood.
Sicherer SH, Warren CM, Dant C, Gupta RS, Nadeau KC
J Allergy Clin Immunol Pract 2020 Jun;8(6):1854-1864. doi: 10.1016/j.jaip.2020.02.010. PMID: 32499034Free PMC Article
International consensus guidelines for the diagnosis and management of food protein-induced enterocolitis syndrome: Executive summary-Workgroup Report of the Adverse Reactions to Foods Committee, American Academy of Allergy, Asthma & Immunology.
Nowak-Węgrzyn A, Chehade M, Groetch ME, Spergel JM, Wood RA, Allen K, Atkins D, Bahna S, Barad AV, Berin C, Brown Whitehorn T, Burks AW, Caubet JC, Cianferoni A, Conte M, Davis C, Fiocchi A, Grimshaw K, Gupta R, Hofmeister B, Hwang JB, Katz Y, Konstantinou GN, Leonard SA, Lightdale J, McGhee S, Mehr S, Sopo SM, Monti G, Muraro A, Noel SK, Nomura I, Noone S, Sampson HA, Schultz F, Sicherer SH, Thompson CC, Turner PJ, Venter C, Westcott-Chavez AA, Greenhawt M
J Allergy Clin Immunol 2017 Apr;139(4):1111-1126.e4. Epub 2017 Feb 4 doi: 10.1016/j.jaci.2016.12.966. PMID: 28167094
Review article: the diagnosis and management of food allergy and food intolerances.
Turnbull JL, Adams HN, Gorard DA
Aliment Pharmacol Ther 2015 Jan;41(1):3-25. Epub 2014 Oct 14 doi: 10.1111/apt.12984. PMID: 25316115

Diagnosis

Food allergy and hypersensitivity reactions in children and adults-A review.
Tedner SG, Asarnoj A, Thulin H, Westman M, Konradsen JR, Nilsson C
J Intern Med 2022 Mar;291(3):283-302. Epub 2021 Dec 22 doi: 10.1111/joim.13422. PMID: 34875122
Cow's Milk Protein Allergy in Term and Preterm Infants: Clinical Manifestations, Immunologic Pathophysiology, and Management Strategies.
Burris AD, Burris J, Järvinen KM
Neoreviews 2020 Dec;21(12):e795-e808. doi: 10.1542/neo.21-12-e795. PMID: 33262206
Food Allergy from Infancy Through Adulthood.
Sicherer SH, Warren CM, Dant C, Gupta RS, Nadeau KC
J Allergy Clin Immunol Pract 2020 Jun;8(6):1854-1864. doi: 10.1016/j.jaip.2020.02.010. PMID: 32499034Free PMC Article
Food Protein-Induced Enterocolitis Syndrome.
Nowak-Wegrzyn A, Berin MC, Mehr S
J Allergy Clin Immunol Pract 2020 Jan;8(1):24-35. doi: 10.1016/j.jaip.2019.08.020. PMID: 31950904
International consensus guidelines for the diagnosis and management of food protein-induced enterocolitis syndrome: Executive summary-Workgroup Report of the Adverse Reactions to Foods Committee, American Academy of Allergy, Asthma & Immunology.
Nowak-Węgrzyn A, Chehade M, Groetch ME, Spergel JM, Wood RA, Allen K, Atkins D, Bahna S, Barad AV, Berin C, Brown Whitehorn T, Burks AW, Caubet JC, Cianferoni A, Conte M, Davis C, Fiocchi A, Grimshaw K, Gupta R, Hofmeister B, Hwang JB, Katz Y, Konstantinou GN, Leonard SA, Lightdale J, McGhee S, Mehr S, Sopo SM, Monti G, Muraro A, Noel SK, Nomura I, Noone S, Sampson HA, Schultz F, Sicherer SH, Thompson CC, Turner PJ, Venter C, Westcott-Chavez AA, Greenhawt M
J Allergy Clin Immunol 2017 Apr;139(4):1111-1126.e4. Epub 2017 Feb 4 doi: 10.1016/j.jaci.2016.12.966. PMID: 28167094

Therapy

Cow's Milk Protein Allergy.
Malik R, Kaul S
Indian J Pediatr 2024 May;91(5):499-506. Epub 2023 Oct 18 doi: 10.1007/s12098-023-04866-5. PMID: 37851326
Update on Food protein-induced enterocolitis syndrome (FPIES).
Calvani M, Anania C, Bianchi A, D'Auria E, Cardinale F, Votto M, Martelli A, Tosca M, Chiappini E, Brambilla I, Miraglia Del Giudice M, Caffarelli C
Acta Biomed 2021 Nov 29;92(S7):e2021518. doi: 10.23750/abm.v92iS7.12394. PMID: 34842596Free PMC Article
Non-IgE-Mediated Gastrointestinal Food Allergies in Children: An Update.
Labrosse R, Graham F, Caubet JC
Nutrients 2020 Jul 14;12(7) doi: 10.3390/nu12072086. PMID: 32674427Free PMC Article
International consensus guidelines for the diagnosis and management of food protein-induced enterocolitis syndrome: Executive summary-Workgroup Report of the Adverse Reactions to Foods Committee, American Academy of Allergy, Asthma & Immunology.
Nowak-Węgrzyn A, Chehade M, Groetch ME, Spergel JM, Wood RA, Allen K, Atkins D, Bahna S, Barad AV, Berin C, Brown Whitehorn T, Burks AW, Caubet JC, Cianferoni A, Conte M, Davis C, Fiocchi A, Grimshaw K, Gupta R, Hofmeister B, Hwang JB, Katz Y, Konstantinou GN, Leonard SA, Lightdale J, McGhee S, Mehr S, Sopo SM, Monti G, Muraro A, Noel SK, Nomura I, Noone S, Sampson HA, Schultz F, Sicherer SH, Thompson CC, Turner PJ, Venter C, Westcott-Chavez AA, Greenhawt M
J Allergy Clin Immunol 2017 Apr;139(4):1111-1126.e4. Epub 2017 Feb 4 doi: 10.1016/j.jaci.2016.12.966. PMID: 28167094
Non-IgE-mediated gastrointestinal food allergy.
Nowak-Węgrzyn A, Katz Y, Mehr SS, Koletzko S
J Allergy Clin Immunol 2015 May;135(5):1114-24. doi: 10.1016/j.jaci.2015.03.025. PMID: 25956013

Prognosis

Cow's Milk Protein Allergy.
Malik R, Kaul S
Indian J Pediatr 2024 May;91(5):499-506. Epub 2023 Oct 18 doi: 10.1007/s12098-023-04866-5. PMID: 37851326
Non-IgE-Mediated Gastrointestinal Food Allergies in Children: An Update.
Labrosse R, Graham F, Caubet JC
Nutrients 2020 Jul 14;12(7) doi: 10.3390/nu12072086. PMID: 32674427Free PMC Article
Food Allergy from Infancy Through Adulthood.
Sicherer SH, Warren CM, Dant C, Gupta RS, Nadeau KC
J Allergy Clin Immunol Pract 2020 Jun;8(6):1854-1864. doi: 10.1016/j.jaip.2020.02.010. PMID: 32499034Free PMC Article
Food protein-induced enterocolitis syndrome.
Caubet JC, Cianferoni A, Groetch M, Nowak-Wegrzyn A
Clin Exp Allergy 2019 Sep;49(9):1178-1190. doi: 10.1111/cea.13415. PMID: 31468626
Non-IgE-mediated gastrointestinal food allergy.
Nowak-Węgrzyn A, Katz Y, Mehr SS, Koletzko S
J Allergy Clin Immunol 2015 May;135(5):1114-24. doi: 10.1016/j.jaci.2015.03.025. PMID: 25956013

Clinical prediction guides

Cow's Milk Protein Allergy.
Malik R, Kaul S
Indian J Pediatr 2024 May;91(5):499-506. Epub 2023 Oct 18 doi: 10.1007/s12098-023-04866-5. PMID: 37851326
Evolution of Food Protein-Induced Enterocolitis Syndrome (FPIES) Index Trigger Foods and Subsequent Reactions After Initial Diagnosis.
Hua A, El-Zataari M, Hudson E, Sanders GM, Schuler CF 4th
J Allergy Clin Immunol Pract 2023 Oct;11(10):3179-3186.e2. Epub 2023 Jun 26 doi: 10.1016/j.jaip.2023.06.032. PMID: 37380072
Food Allergy from Infancy Through Adulthood.
Sicherer SH, Warren CM, Dant C, Gupta RS, Nadeau KC
J Allergy Clin Immunol Pract 2020 Jun;8(6):1854-1864. doi: 10.1016/j.jaip.2020.02.010. PMID: 32499034Free PMC Article
Microbiota in non-IgE-mediated food allergy.
Mennini M, Fierro V, Di Nardo G, Pecora V, Fiocchi A
Curr Opin Allergy Clin Immunol 2020 Jun;20(3):323-328. doi: 10.1097/ACI.0000000000000644. PMID: 32250972
Severe forms of food allergy.
Sarinho E, Lins MDGM
J Pediatr (Rio J) 2017 Nov-Dec;93 Suppl 1:53-59. Epub 2017 Sep 21 doi: 10.1016/j.jped.2017.06.021. PMID: 28941390

Recent systematic reviews

A systematic review and expert Delphi Consensus recommendation on the use of vaccines in patients receiving dupilumab: A position paper of the American College of Allergy, Asthma and Immunology.
Lieberman JA, Chu DK, Ahmed T, Dribin TE, Abrams EM, Anagnostou A, Blumenthal KG, Boguniewicz M, Chase NM, Golden DBK, Hartog NL, Heimall JR, Ho T, Lawrence MG, Khan DA, Minniear TD, Mustafa SS, Oppenheimer JJ, Phillips EJ, Ramsey A, Rider NL, Schneider L, Shaker MS, Spergel JM, Stone CA Jr, Stukus DR, Wang J, Greenhawt MJ
Ann Allergy Asthma Immunol 2024 Sep;133(3):286-294. Epub 2024 Jun 5 doi: 10.1016/j.anai.2024.05.014. PMID: 38848870
Outcomes reported in randomized controlled trials for mixed and non-IgE-mediated food allergy: Systematic review.
Bel Imam M, Stikas CV, Guha P, Chawes BL, Chu D, Greenhawt M, Khaleva E, Munblit D, Nekliudov N, van de Veen W, Schoos AM; Core Outcome Measures for Food Allergy (COMFA) consortium
Clin Exp Allergy 2023 May;53(5):526-535. Epub 2023 Mar 7 doi: 10.1111/cea.14304. PMID: 36880564
Risk of Second Allergic Reaction to SARS-CoV-2 Vaccines: A Systematic Review and Meta-analysis.
Chu DK, Abrams EM, Golden DBK, Blumenthal KG, Wolfson AR, Stone CA Jr, Krantz MS, Shaker M, Greenhawt M
JAMA Intern Med 2022 Apr 1;182(4):376-385. doi: 10.1001/jamainternmed.2021.8515. PMID: 35188528Free PMC Article
A systematic review of food protein-induced enterocolitis syndrome from the last 40 years.
Manti S, Leonardi S, Salpietro A, Del Campo G, Salpietro C, Cuppari C
Ann Allergy Asthma Immunol 2017 Apr;118(4):411-418. doi: 10.1016/j.anai.2017.02.005. PMID: 28390583
Early additional food and fluids for healthy breastfed full-term infants.
Smith HA, Becker GE
Cochrane Database Syst Rev 2016 Aug 30;2016(8):CD006462. doi: 10.1002/14651858.CD006462.pub4. PMID: 27574798Free PMC Article

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