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Generalized morning stiffness

MedGen UID:
870781
•Concept ID:
C4025238
•
Finding
Synonym: Generalised morning stiffness
 
HPO: HP:0005197

Definition

A sensation of stiffness in the joints that occurs following waking up in the morning. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGeneralized morning stiffness

Conditions with this feature

Camptodactyly-arthropathy-coxa vara-pericarditis syndrome
MedGen UID:
349226
•Concept ID:
C1859690
•
Disease or Syndrome
The camptodactyly-arthropathy-coxa vara-pericarditis syndrome (CACP) is an autosomal recessive condition characterized by the association of congenital or early-onset camptodactyly and noninflammatory arthropathy with synovial hyperplasia. Progressive coxa vara deformity and/or noninflammatory pericardial or pleural effusions are found in some patients (summary by Faivre et al., 2000).
See: Condition Record
Camptodactyly-arthropathy-coxa vara-pericarditis syndrome

Professional guidelines

PubMed

Management of fibromyalgia.
Patkar AA, Bilal L, Masand PS
Curr Psychiatry Rep 2003 Jul;5(3):218-24. doi: 10.1007/s11920-003-0046-9. PMID: 12773276

Recent clinical studies

Etiology

Knee Osteoarthritis.
Gelber AC
Ann Intern Med 2024 Sep;177(9):ITC129-ITC144. Epub 2024 Sep 10 doi: 10.7326/ANNALS-24-01249. PMID: 39250809
Back Pain in Children and Adolescents.
Achar S, Yamanaka J
Am Fam Physician 2020 Jul 1;102(1):19-28. PMID: 32603067
EULAR evidence-based recommendations for the diagnosis of knee osteoarthritis.
Zhang W, Doherty M, Peat G, Bierma-Zeinstra MA, Arden NK, Bresnihan B, Herrero-Beaumont G, Kirschner S, Leeb BF, Lohmander LS, Mazières B, Pavelka K, Punzi L, So AK, Tuncer T, Watt I, Bijlsma JW
Ann Rheum Dis 2010 Mar;69(3):483-9. Epub 2009 Sep 17 doi: 10.1136/ard.2009.113100. PMID: 19762361
Fibromyalgia.
Chakrabarty S, Zoorob R
Am Fam Physician 2007 Jul 15;76(2):247-54. PMID: 17695569
Methotrexate for ankylosing spondylitis.
Chen J, Liu C, Lin J
Cochrane Database Syst Rev 2006 Oct 18;(4):CD004524. doi: 10.1002/14651858.CD004524.pub3. PMID: 17054209

Diagnosis

Evaluation and Treatment of Knee Pain: A Review.
Duong V, Oo WM, Ding C, Culvenor AG, Hunter DJ
JAMA 2023 Oct 24;330(16):1568-1580. doi: 10.1001/jama.2023.19675. PMID: 37874571
An update on polymyalgia rheumatica.
Lundberg IE, Sharma A, Turesson C, Mohammad AJ
J Intern Med 2022 Nov;292(5):717-732. Epub 2022 Jun 11 doi: 10.1111/joim.13525. PMID: 35612524Free PMC Article
Osteoarthritis: Rapid Evidence Review.
Ebell MH
Am Fam Physician 2018 Apr 15;97(8):523-526. PMID: 29671497
Rheumatoid arthritis.
Ngian GS
Aust Fam Physician 2010 Sep;39(9):626-8. PMID: 20877764
The clinical features of rheumatoid arthritis.
Grassi W, De Angelis R, Lamanna G, Cervini C
Eur J Radiol 1998 May;27 Suppl 1:S18-24. doi: 10.1016/s0720-048x(98)00038-2. PMID: 9652497

Therapy

An update on polymyalgia rheumatica.
Lundberg IE, Sharma A, Turesson C, Mohammad AJ
J Intern Med 2022 Nov;292(5):717-732. Epub 2022 Jun 11 doi: 10.1111/joim.13525. PMID: 35612524Free PMC Article
Back Pain in Children and Adolescents.
Achar S, Yamanaka J
Am Fam Physician 2020 Jul 1;102(1):19-28. PMID: 32603067
Rheumatoid arthritis.
Ngian GS
Aust Fam Physician 2010 Sep;39(9):626-8. PMID: 20877764
Fibromyalgia.
Chakrabarty S, Zoorob R
Am Fam Physician 2007 Jul 15;76(2):247-54. PMID: 17695569
Methotrexate for ankylosing spondylitis.
Chen J, Liu C, Lin J
Cochrane Database Syst Rev 2006 Oct 18;(4):CD004524. doi: 10.1002/14651858.CD004524.pub3. PMID: 17054209

Prognosis

An update on polymyalgia rheumatica.
Lundberg IE, Sharma A, Turesson C, Mohammad AJ
J Intern Med 2022 Nov;292(5):717-732. Epub 2022 Jun 11 doi: 10.1111/joim.13525. PMID: 35612524Free PMC Article
EULAR evidence-based recommendations for the diagnosis of knee osteoarthritis.
Zhang W, Doherty M, Peat G, Bierma-Zeinstra MA, Arden NK, Bresnihan B, Herrero-Beaumont G, Kirschner S, Leeb BF, Lohmander LS, Mazières B, Pavelka K, Punzi L, So AK, Tuncer T, Watt I, Bijlsma JW
Ann Rheum Dis 2010 Mar;69(3):483-9. Epub 2009 Sep 17 doi: 10.1136/ard.2009.113100. PMID: 19762361
Fibromyalgia.
Chakrabarty S, Zoorob R
Am Fam Physician 2007 Jul 15;76(2):247-54. PMID: 17695569
Management of fibromyalgia.
Patkar AA, Bilal L, Masand PS
Curr Psychiatry Rep 2003 Jul;5(3):218-24. doi: 10.1007/s11920-003-0046-9. PMID: 12773276
The clinical features of rheumatoid arthritis.
Grassi W, De Angelis R, Lamanna G, Cervini C
Eur J Radiol 1998 May;27 Suppl 1:S18-24. doi: 10.1016/s0720-048x(98)00038-2. PMID: 9652497

Clinical prediction guides

3. Pain originating from the lumbar facet joints.
Van den Heuvel SAS, Cohen SPC, de Andrès Ares J, Van Boxem K, Kallewaard JW, Van Zundert J
Pain Pract 2024 Jan;24(1):160-176. Epub 2023 Aug 28 doi: 10.1111/papr.13287. PMID: 37640913
Evaluation and Treatment of Knee Pain: A Review.
Duong V, Oo WM, Ding C, Culvenor AG, Hunter DJ
JAMA 2023 Oct 24;330(16):1568-1580. doi: 10.1001/jama.2023.19675. PMID: 37874571
Association between clinical findings and the presence of lumbar spine osteoarthritis imaging features: A systematic review.
Chamoro M, de Luca K, Ozbulut O, Oei EHG, Vleggeert-Lankamp CLA, Koes BW, Bierma-Zeinstra SMA, Chiarotto A
Osteoarthritis Cartilage 2023 Sep;31(9):1158-1175. Epub 2023 May 6 doi: 10.1016/j.joca.2023.04.014. PMID: 37150286
An update on polymyalgia rheumatica.
Lundberg IE, Sharma A, Turesson C, Mohammad AJ
J Intern Med 2022 Nov;292(5):717-732. Epub 2022 Jun 11 doi: 10.1111/joim.13525. PMID: 35612524Free PMC Article
EULAR evidence-based recommendations for the diagnosis of knee osteoarthritis.
Zhang W, Doherty M, Peat G, Bierma-Zeinstra MA, Arden NK, Bresnihan B, Herrero-Beaumont G, Kirschner S, Leeb BF, Lohmander LS, Mazières B, Pavelka K, Punzi L, So AK, Tuncer T, Watt I, Bijlsma JW
Ann Rheum Dis 2010 Mar;69(3):483-9. Epub 2009 Sep 17 doi: 10.1136/ard.2009.113100. PMID: 19762361

Recent systematic reviews

Association between clinical findings and the presence of lumbar spine osteoarthritis imaging features: A systematic review.
Chamoro M, de Luca K, Ozbulut O, Oei EHG, Vleggeert-Lankamp CLA, Koes BW, Bierma-Zeinstra SMA, Chiarotto A
Osteoarthritis Cartilage 2023 Sep;31(9):1158-1175. Epub 2023 May 6 doi: 10.1016/j.joca.2023.04.014. PMID: 37150286
TNF-alpha inhibitors for ankylosing spondylitis.
Maxwell LJ, Zochling J, Boonen A, Singh JA, Veras MM, Tanjong Ghogomu E, Benkhalti Jandu M, Tugwell P, Wells GA
Cochrane Database Syst Rev 2015 Apr 18;2015(4):CD005468. doi: 10.1002/14651858.CD005468.pub2. PMID: 25887212Free PMC Article
Methotrexate for treating rheumatoid arthritis.
Lopez-Olivo MA, Siddhanamatha HR, Shea B, Tugwell P, Wells GA, Suarez-Almazor ME
Cochrane Database Syst Rev 2014 Jun 10;2014(6):CD000957. doi: 10.1002/14651858.CD000957.pub2. PMID: 24916606Free PMC Article
Methotrexate for ankylosing spondylitis.
Chen J, Liu C, Lin J
Cochrane Database Syst Rev 2006 Oct 18;(4):CD004524. doi: 10.1002/14651858.CD004524.pub3. PMID: 17054209
Sulfasalazine for ankylosing spondylitis.
Chen J, Liu C
Cochrane Database Syst Rev 2005 Apr 18;(2):CD004800. doi: 10.1002/14651858.CD004800.pub2. PMID: 15846731

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