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Abnormal sperm mid-piece morphology

MedGen UID:: 868306
•Concept ID:: C4022700
•: Finding

Synonym:	Sperm mid-piece anomaly

HPO:	HP:0012867

Definition

A structural abnormality of the sperm mid-piece. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVAbnormal sperm mid-piece morphology

Abnormality of the genitourinary system
- Abnormality of the genital system
  - Abnormal reproductive system morphology
    - Abnormal germ cell morphology
      - Abnormal male germ cell morphology
        Abnormal sperm morphology
        Abnormal sperm mid-piece morphology
        Asymmetrical insertion of the midpiece into the head
        Thick spermatozoon midpiece insertion
        Thin spermatozoon midpiece

Conditions with this feature

Spermatogenic failure 65

MedGen UID:: 1794277
•Concept ID:: C5562067
•: Disease or Syndrome

Spermatogenic failure-65 (SPGF65) is characterized by male infertility due to asthenoteratozoospermia. Progressive sperm motility is severely reduced or absent, and patients exhibit multiple morphologic abnormalities of the flagella (MMAF), including coiled, irregular-caliber, short, and absent flagella. Abnormalities of the flagellar midpiece are also present (Tan et al., 2022). For a general phenotypic description and discussion of genetic heterogeneity of SPGF, see SPGF1 (258150).

See: Condition Record

Spermatogenic failure 65

Recent clinical studies

Etiology

Tales of the tail and sperm head aches: changing concepts on the prognostic significance of sperm pathologies affecting the head, neck and tail.

Chemes HE, Alvarez Sedo C
Asian J Androl 2012 Jan;14(1):14-23. Epub 2011 Dec 26 doi: 10.1038/aja.2011.168. PMID: 22198630 Free PMC Article

Results of varicocelectomy in patients with isolated teratozoospermia.

Cakan M, Bakirtas H, Aldemir M, Demirel F, Altug U
Urol Int 2008;80(2):172-6. Epub 2008 Mar 19 doi: 10.1159/000112609. PMID: 18362488

The morphology of extracted testicular sperm correlates with fertilization but not pregnancy rates.

Schiff JD, Luna M, Barritt J, Duke M, Copperman A, Bar-Chama N
BJU Int 2007 Dec;100(6):1326-9. doi: 10.1111/j.1464-410X.2007.07187.x. PMID: 17979931

Chromosome abnormalities in sperm from infertile men with normal somatic karyotypes: teratozoospermia.

Machev N, Gosset P, Viville S
Cytogenet Genome Res 2005;111(3-4):352-7. doi: 10.1159/000086910. PMID: 16192715

Evaluation of a cut-off value for normal sperm morphology using strict criteria to predict fertilization after conventional in-vitro fertilization and embryo transfer in asthenozoospermia.

Zollner U, Schleyer M, Steck T
Hum Reprod 1996 Oct;11(10):2155-61. doi: 10.1093/oxfordjournals.humrep.a019068. PMID: 8943521

See all (11)

Diagnosis

Haploid male germ cells-the Grand Central Station of protein transport.

Pleuger C, Lehti MS, Dunleavy JE, Fietz D, O'Bryan MK
Hum Reprod Update 2020 Jun 18;26(4):474-500. doi: 10.1093/humupd/dmaa004. PMID: 32318721

Tales of the tail and sperm head aches: changing concepts on the prognostic significance of sperm pathologies affecting the head, neck and tail.

Chemes HE, Alvarez Sedo C
Asian J Androl 2012 Jan;14(1):14-23. Epub 2011 Dec 26 doi: 10.1038/aja.2011.168. PMID: 22198630 Free PMC Article

Colonization of Gardnerella vaginalis in semen of infertile men: prevalence, influence on sperm characteristics, relationship with leukocyte concentration and clinical significance.

Andrade-Rocha FT
Gynecol Obstet Invest 2009;68(2):134-6. Epub 2009 Jul 15 doi: 10.1159/000228583. PMID: 19602896

Human spermatozoa ultrastructure assessment in the infertility treatment by assisted reproduction technique.

Małgorzata K, Depa-Martynów M, Butowska W, Filipiak K, Pawelczyk L, Jedrzejczak P
Arch Androl 2007 Nov-Dec;53(6):297-302. doi: 10.1080/01485010701730708. PMID: 18357958

Ultrastructure of gametes and intracytoplasmic sperm injection: the significance of sperm morphology.

Küpker W, Schulze W, Diedrich K
Hum Reprod 1998 Apr;13 Suppl 1:99-106. doi: 10.1093/humrep/13.suppl_1.99. PMID: 9663774

See all (6)

Therapy

Novel IFT140 variants cause spermatogenic dysfunction in humans.

Wang X, Sha YW, Wang WT, Cui YQ, Chen J, Yan W, Hou XT, Mei LB, Yu CC, Wang J
Mol Genet Genomic Med 2019 Sep;7(9):e920. Epub 2019 Aug 8 doi: 10.1002/mgg3.920. PMID: 31397098 Free PMC Article

Evaluation of a cut-off value for normal sperm morphology using strict criteria to predict fertilization after conventional in-vitro fertilization and embryo transfer in asthenozoospermia.

Zollner U, Schleyer M, Steck T
Hum Reprod 1996 Oct;11(10):2155-61. doi: 10.1093/oxfordjournals.humrep.a019068. PMID: 8943521

Morphometric characteristics of motile spermatozoa in subfertile men with an excess of non-sperm cells in the ejaculate.

Mundy AJ, Ryder TA, Edmonds DK
Hum Reprod 1994 Sep;9(9):1701-4. doi: 10.1093/oxfordjournals.humrep.a138777. PMID: 7836521

See all (3)

Prognosis

Novel IFT140 variants cause spermatogenic dysfunction in humans.

Wang X, Sha YW, Wang WT, Cui YQ, Chen J, Yan W, Hou XT, Mei LB, Yu CC, Wang J
Mol Genet Genomic Med 2019 Sep;7(9):e920. Epub 2019 Aug 8 doi: 10.1002/mgg3.920. PMID: 31397098 Free PMC Article

Tales of the tail and sperm head aches: changing concepts on the prognostic significance of sperm pathologies affecting the head, neck and tail.

Chemes HE, Alvarez Sedo C
Asian J Androl 2012 Jan;14(1):14-23. Epub 2011 Dec 26 doi: 10.1038/aja.2011.168. PMID: 22198630 Free PMC Article

Ultrastructure of gametes and intracytoplasmic sperm injection: the significance of sperm morphology.

Küpker W, Schulze W, Diedrich K
Hum Reprod 1998 Apr;13 Suppl 1:99-106. doi: 10.1093/humrep/13.suppl_1.99. PMID: 9663774

Evaluation of a cut-off value for normal sperm morphology using strict criteria to predict fertilization after conventional in-vitro fertilization and embryo transfer in asthenozoospermia.

Zollner U, Schleyer M, Steck T
Hum Reprod 1996 Oct;11(10):2155-61. doi: 10.1093/oxfordjournals.humrep.a019068. PMID: 8943521

Linear and non-linear relationships between the 'swelling test' and conventional semen variables in men suspected of primary infertility.

Colpi GM, Sagone P, Tognetti A, Campana A, Piffaretti-Yanez A, Balerna M
Hum Reprod 1990 Jul;5(5):600-5. doi: 10.1093/oxfordjournals.humrep.a137152. PMID: 2394791

See all (5)

Clinical prediction guides

LRRC46 Accumulates at the Midpiece of Sperm Flagella and Is Essential for Spermiogenesis and Male Fertility in Mouse.

Yin Y, Mu W, Yu X, Wang Z, Xu K, Wu X, Cai Y, Zhang M, Lu G, Chan WY, Ma J, Huang T, Liu H
Int J Mol Sci 2022 Jul 31;23(15) doi: 10.3390/ijms23158525. PMID: 35955660 Free PMC Article

Novel IFT140 variants cause spermatogenic dysfunction in humans.

Wang X, Sha YW, Wang WT, Cui YQ, Chen J, Yan W, Hou XT, Mei LB, Yu CC, Wang J
Mol Genet Genomic Med 2019 Sep;7(9):e920. Epub 2019 Aug 8 doi: 10.1002/mgg3.920. PMID: 31397098 Free PMC Article

Sperm with fibrous sheath dysplasia and anomalies in head-neck junction: focus on centriole and centrin 1.

Moretti E, Pascarelli NA, Belmonte G, Renieri T, Collodel G
Andrologia 2017 Sep;49(7) Epub 2016 Sep 5 doi: 10.1111/and.12701. PMID: 27596234

Chromosome abnormalities in sperm from infertile men with normal somatic karyotypes: teratozoospermia.

Machev N, Gosset P, Viville S
Cytogenet Genome Res 2005;111(3-4):352-7. doi: 10.1159/000086910. PMID: 16192715

Ultrastructure of gametes and intracytoplasmic sperm injection: the significance of sperm morphology.

Küpker W, Schulze W, Diedrich K
Hum Reprod 1998 Apr;13 Suppl 1:99-106. doi: 10.1093/humrep/13.suppl_1.99. PMID: 9663774

See all (11)

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Abnormal sperm mid-piece morphology

Definition

Term Hierarchy

Conditions with this feature

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Supplemental Content

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Clinical resources

Consumer resources

Reviews

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