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Severe left ventricular systolic dysfunction

MedGen UID:
781675
•Concept ID:
C3266753
•
Disease or Syndrome
SNOMED CT: Severe left ventricular systolic dysfunction (991000124109)

Professional guidelines

PubMed

Evaluation and Management of Patients With Stable Angina: Beyond the Ischemia Paradigm: JACC State-of-the-Art Review.
Ferraro R, Latina JM, Alfaddagh A, Michos ED, Blaha MJ, Jones SR, Sharma G, Trost JC, Boden WE, Weintraub WS, Lima JAC, Blumenthal RS, Fuster V, Arbab-Zadeh A
J Am Coll Cardiol 2020 Nov 10;76(19):2252-2266. doi: 10.1016/j.jacc.2020.08.078. PMID: 33153586
The management of patients with aortic regurgitation and severe left ventricular dysfunction: a systematic review.
Badar AA, Brunton AP, Mahmood AH, Dobbin S, Pozzi A, McMinn JF, Sinclair AJ, Gardner RS, Petrie MC, Curry PA, Al-Attar NH, Pettit SJ
Expert Rev Cardiovasc Ther 2015;13(8):915-22. Epub 2015 Jul 10 doi: 10.1586/14779072.2015.1067139. PMID: 26163051
Barriers to patients eligible for screening investigations and insertion of primary prevention implantable cardioverter defibrillators.
Sadarmin PP, Wong KC, Rajappan K, Bashir Y, Betts TR
Europace 2014 Nov;16(11):1575-9. Epub 2014 Mar 25 doi: 10.1093/europace/euu054. PMID: 24668515

Recent clinical studies

Etiology

Is venoarterial extracorporeal membrane oxygenation an option for managing septic shock.
Helwani MA, Lim A
Curr Opin Anaesthesiol 2023 Feb 1;36(1):45-49. Epub 2022 Nov 15 doi: 10.1097/ACO.0000000000001206. PMID: 36550604
Evaluation and Management of Patients With Stable Angina: Beyond the Ischemia Paradigm: JACC State-of-the-Art Review.
Ferraro R, Latina JM, Alfaddagh A, Michos ED, Blaha MJ, Jones SR, Sharma G, Trost JC, Boden WE, Weintraub WS, Lima JAC, Blumenthal RS, Fuster V, Arbab-Zadeh A
J Am Coll Cardiol 2020 Nov 10;76(19):2252-2266. doi: 10.1016/j.jacc.2020.08.078. PMID: 33153586
Coronary-Artery Bypass Surgery in Patients with Ischemic Cardiomyopathy.
Velazquez EJ, Lee KL, Jones RH, Al-Khalidi HR, Hill JA, Panza JA, Michler RE, Bonow RO, Doenst T, Petrie MC, Oh JK, She L, Moore VL, Desvigne-Nickens P, Sopko G, Rouleau JL; STICHES Investigators
N Engl J Med 2016 Apr 21;374(16):1511-20. Epub 2016 Apr 3 doi: 10.1056/NEJMoa1602001. PMID: 27040723Free PMC Article
Sudden cardiac death.
Kuriachan VP, Sumner GL, Mitchell LB
Curr Probl Cardiol 2015 Apr;40(4):133-200. Epub 2015 Feb 7 doi: 10.1016/j.cpcardiol.2015.01.002. PMID: 25813838
Revascularization in severe left ventricular dysfunction.
Velazquez EJ, Bonow RO
J Am Coll Cardiol 2015 Feb 17;65(6):615-24. doi: 10.1016/j.jacc.2014.10.070. PMID: 25677320

Diagnosis

Multivessel versus IRA-only PCI in patients with NSTEMI and severe left ventricular systolic dysfunction.
Lee M, Kim DW, Park MW, Lee K, Her SH, Chang K, Chung WS, Jeong MH, Rha SW, Kim HS, Gwon HC, Seong IW, Hwang KK, Chae SC, Kim KB, Kim YJ, Cha KS, Oh SK, Chae JK, Jung JH; KAMIR-NIH registry investigators
PLoS One 2021;16(10):e0258525. Epub 2021 Oct 13 doi: 10.1371/journal.pone.0258525. PMID: 34644362Free PMC Article
Electrical surrogate for detection of severe left ventricular systolic dysfunction.
Reinier K, Aro AL, Uy-Evanado A, Rusinaru C, Chugh HS, Shiota T, Jui J, Chugh SS
Ann Noninvasive Electrocardiol 2018 Nov;23(6):e12591. Epub 2018 Aug 20 doi: 10.1111/anec.12591. PMID: 30126010Free PMC Article
The Causes of HIV-Associated Cardiomyopathy: A Tale of Two Worlds.
Lumsden RH, Bloomfield GS
Biomed Res Int 2016;2016:8196560. Epub 2016 Jan 17 doi: 10.1155/2016/8196560. PMID: 26885518Free PMC Article
Revascularization in severe left ventricular dysfunction.
Velazquez EJ, Bonow RO
J Am Coll Cardiol 2015 Feb 17;65(6):615-24. doi: 10.1016/j.jacc.2014.10.070. PMID: 25677320
Myocardial viability imaging and revascularization in chronic ischemic left ventricular systolic dysfunction.
Tajouri TH, Chareonthaitawee P
Expert Rev Cardiovasc Ther 2010 Jan;8(1):55-63. doi: 10.1586/erc.09.157. PMID: 20014935

Therapy

Multivessel versus IRA-only PCI in patients with NSTEMI and severe left ventricular systolic dysfunction.
Lee M, Kim DW, Park MW, Lee K, Her SH, Chang K, Chung WS, Jeong MH, Rha SW, Kim HS, Gwon HC, Seong IW, Hwang KK, Chae SC, Kim KB, Kim YJ, Cha KS, Oh SK, Chae JK, Jung JH; KAMIR-NIH registry investigators
PLoS One 2021;16(10):e0258525. Epub 2021 Oct 13 doi: 10.1371/journal.pone.0258525. PMID: 34644362Free PMC Article
Evaluation and Management of Patients With Stable Angina: Beyond the Ischemia Paradigm: JACC State-of-the-Art Review.
Ferraro R, Latina JM, Alfaddagh A, Michos ED, Blaha MJ, Jones SR, Sharma G, Trost JC, Boden WE, Weintraub WS, Lima JAC, Blumenthal RS, Fuster V, Arbab-Zadeh A
J Am Coll Cardiol 2020 Nov 10;76(19):2252-2266. doi: 10.1016/j.jacc.2020.08.078. PMID: 33153586
Coronary-Artery Bypass Surgery in Patients with Ischemic Cardiomyopathy.
Velazquez EJ, Lee KL, Jones RH, Al-Khalidi HR, Hill JA, Panza JA, Michler RE, Bonow RO, Doenst T, Petrie MC, Oh JK, She L, Moore VL, Desvigne-Nickens P, Sopko G, Rouleau JL; STICHES Investigators
N Engl J Med 2016 Apr 21;374(16):1511-20. Epub 2016 Apr 3 doi: 10.1056/NEJMoa1602001. PMID: 27040723Free PMC Article
Myocardial viability imaging and revascularization in chronic ischemic left ventricular systolic dysfunction.
Tajouri TH, Chareonthaitawee P
Expert Rev Cardiovasc Ther 2010 Jan;8(1):55-63. doi: 10.1586/erc.09.157. PMID: 20014935
What is cardiac resynchronization therapy?
Barold SS
Am J Med 2001 Aug 15;111(3):224-32. doi: 10.1016/s0002-9343(01)00807-5. PMID: 11530034

Prognosis

Myocardial stress perfusion scintigraphy for outcome prediction in patients with severe left ventricular systolic dysfunction.
Gimelli A, Aimo A, Pasanisi EM, Coceani MA, Clemente A, Emdin M, Shaw LJ
Eur J Nucl Med Mol Imaging 2021 Oct;48(11):3502-3511. Epub 2021 Mar 18 doi: 10.1007/s00259-021-05312-4. PMID: 33735407
Fulminant Versus Acute Nonfulminant Myocarditis in Patients With Left Ventricular Systolic Dysfunction.
Ammirati E, Veronese G, Brambatti M, Merlo M, Cipriani M, Potena L, Sormani P, Aoki T, Sugimura K, Sawamura A, Okumura T, Pinney S, Hong K, Shah P, Braun Ö, Van de Heyning CM, Montero S, Petrella D, Huang F, Schmidt M, Raineri C, Lala A, Varrenti M, Foà A, Leone O, Gentile P, Artico J, Agostini V, Patel R, Garascia A, Van Craenenbroeck EM, Hirose K, Isotani A, Murohara T, Arita Y, Sionis A, Fabris E, Hashem S, Garcia-Hernando V, Oliva F, Greenberg B, Shimokawa H, Sinagra G, Adler ED, Frigerio M, Camici PG
J Am Coll Cardiol 2019 Jul 23;74(3):299-311. doi: 10.1016/j.jacc.2019.04.063. PMID: 31319912
Electrical surrogate for detection of severe left ventricular systolic dysfunction.
Reinier K, Aro AL, Uy-Evanado A, Rusinaru C, Chugh HS, Shiota T, Jui J, Chugh SS
Ann Noninvasive Electrocardiol 2018 Nov;23(6):e12591. Epub 2018 Aug 20 doi: 10.1111/anec.12591. PMID: 30126010Free PMC Article
Coronary-Artery Bypass Surgery in Patients with Ischemic Cardiomyopathy.
Velazquez EJ, Lee KL, Jones RH, Al-Khalidi HR, Hill JA, Panza JA, Michler RE, Bonow RO, Doenst T, Petrie MC, Oh JK, She L, Moore VL, Desvigne-Nickens P, Sopko G, Rouleau JL; STICHES Investigators
N Engl J Med 2016 Apr 21;374(16):1511-20. Epub 2016 Apr 3 doi: 10.1056/NEJMoa1602001. PMID: 27040723Free PMC Article
Acute and Chronic Pheochromocytoma-Induced Cardiomyopathies: Different Prognoses?: A Systematic Analytical Review.
Batisse-Lignier M, Pereira B, Motreff P, Pierrard R, Burnot C, Vorilhon C, Maqdasy S, Roche B, Desbiez F, Clerfond G, Citron B, Lusson JR, Tauveron I, Eschalier R
Medicine (Baltimore) 2015 Dec;94(50):e2198. doi: 10.1097/MD.0000000000002198. PMID: 26683930Free PMC Article

Clinical prediction guides

Is venoarterial extracorporeal membrane oxygenation an option for managing septic shock.
Helwani MA, Lim A
Curr Opin Anaesthesiol 2023 Feb 1;36(1):45-49. Epub 2022 Nov 15 doi: 10.1097/ACO.0000000000001206. PMID: 36550604
Electrical surrogate for detection of severe left ventricular systolic dysfunction.
Reinier K, Aro AL, Uy-Evanado A, Rusinaru C, Chugh HS, Shiota T, Jui J, Chugh SS
Ann Noninvasive Electrocardiol 2018 Nov;23(6):e12591. Epub 2018 Aug 20 doi: 10.1111/anec.12591. PMID: 30126010Free PMC Article
The management of patients with aortic regurgitation and severe left ventricular dysfunction: a systematic review.
Badar AA, Brunton AP, Mahmood AH, Dobbin S, Pozzi A, McMinn JF, Sinclair AJ, Gardner RS, Petrie MC, Curry PA, Al-Attar NH, Pettit SJ
Expert Rev Cardiovasc Ther 2015;13(8):915-22. Epub 2015 Jul 10 doi: 10.1586/14779072.2015.1067139. PMID: 26163051
Severe left ventricular systolic dysfunction may reverse with renal transplantation: uremic cardiomyopathy and cardiorenal syndrome.
Zolty R, Hynes PJ, Vittorio TJ
Am J Transplant 2008 Nov;8(11):2219-24. Epub 2008 Sep 19 doi: 10.1111/j.1600-6143.2008.02407.x. PMID: 18808406
What is cardiac resynchronization therapy?
Barold SS
Am J Med 2001 Aug 15;111(3):224-32. doi: 10.1016/s0002-9343(01)00807-5. PMID: 11530034

Recent systematic reviews

Persistence of significant secondary mitral regurgitation post-cardiac resynchronization therapy and survival: a systematic review and meta-analysis : Mitral regurgitation and mortality post-CRT.
Yuyun MF, Joseph J, Erqou SA, Kinlay S, Echouffo-Tcheugui JB, Peralta AO, Hoffmeister PS, Boden WE, Yarmohammadi H, Martin DT, Singh JP
Heart Fail Rev 2024 Jan;29(1):165-178. Epub 2023 Oct 19 doi: 10.1007/s10741-023-10359-6. PMID: 37855988
Effect of direct oral anticoagulants versus vitamin K antagonists or warfarin in patients with left ventricular thrombus outcomes: A systematic review and meta-analysis.
da Silva Ferreira H, Lima Lopes J, Augusto J, Simões J, Roque D, Faria D, Ferreira J, Fialho I, Beringuilho M, Morais H, Ferreira AR, Morais J, Morais C
Rev Port Cardiol 2023 Jan;42(1):63-70. Epub 2022 Nov 9 doi: 10.1016/j.repc.2021.11.013. PMID: 36370988
Acute and Chronic Pheochromocytoma-Induced Cardiomyopathies: Different Prognoses?: A Systematic Analytical Review.
Batisse-Lignier M, Pereira B, Motreff P, Pierrard R, Burnot C, Vorilhon C, Maqdasy S, Roche B, Desbiez F, Clerfond G, Citron B, Lusson JR, Tauveron I, Eschalier R
Medicine (Baltimore) 2015 Dec;94(50):e2198. doi: 10.1097/MD.0000000000002198. PMID: 26683930Free PMC Article
The management of patients with aortic regurgitation and severe left ventricular dysfunction: a systematic review.
Badar AA, Brunton AP, Mahmood AH, Dobbin S, Pozzi A, McMinn JF, Sinclair AJ, Gardner RS, Petrie MC, Curry PA, Al-Attar NH, Pettit SJ
Expert Rev Cardiovasc Ther 2015;13(8):915-22. Epub 2015 Jul 10 doi: 10.1586/14779072.2015.1067139. PMID: 26163051
Left ventricular thrombus formation and cardioembolic complications in patients with Takotsubo-like syndrome: a systematic review.
de Gregorio C, Grimaldi P, Lentini C
Int J Cardiol 2008 Dec 17;131(1):18-24. Epub 2008 Aug 8 doi: 10.1016/j.ijcard.2008.05.060. PMID: 18692258

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