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Non-Erosive Reflux Disease

MedGen UID:
1827120
•Concept ID:
C2242528
•
Disease or Syndrome
Synonyms: Disease, Non-Erosive Reflux; Diseases, Non-Erosive Reflux; GERD, Non-Erosive; NERD Non Erosive Reflux Disease; NERD Non-Erosive Reflux Disease; Non Erosive GERD; Non Erosive Reflux Disease; Non-Erosive GERD; Non-Erosive Reflux Diseases; Reflux Disease, Non-Erosive; Reflux Diseases, Non-Erosive

Definition

A type of gastroesophageal reflux disease with acid reflux-related symptoms, but that does not affect the integrity of the ESOPHAGEAL MUCOSA. [from MeSH]

Professional guidelines

PubMed

Evidence-based clinical practice guidelines for gastroesophageal reflux disease 2021.
Iwakiri K, Fujiwara Y, Manabe N, Ihara E, Kuribayashi S, Akiyama J, Kondo T, Yamashita H, Ishimura N, Kitasako Y, Iijima K, Koike T, Omura N, Nomura T, Kawamura O, Ohara S, Ozawa S, Kinoshita Y, Mochida S, Enomoto N, Shimosegawa T, Koike K
J Gastroenterol 2022 Apr;57(4):267-285. Epub 2022 Feb 28 doi: 10.1007/s00535-022-01861-z. PMID: 35226174Free PMC Article
Advances in the diagnosis and management of gastroesophageal reflux disease.
Katzka DA, Kahrilas PJ
BMJ 2020 Nov 23;371:m3786. doi: 10.1136/bmj.m3786. PMID: 33229333
Medical treatment of gastroesophageal reflux disease.
Bor S, Kalkan İH
Turk J Gastroenterol 2017 Dec;28(Suppl 1):S48-S52. doi: 10.5152/tjg.2017.13. PMID: 29199168

Recent clinical studies

Etiology

Randomised clinical trial: Efficacy and safety of on-demand vonoprazan versus placebo for non-erosive reflux disease.
Fass R, Vaezi M, Sharma P, Yadlapati R, Hunt B, Harris T, Smith N, Leifke E, Armstrong D
Aliment Pharmacol Ther 2023 Nov;58(10):1016-1027. Epub 2023 Sep 26 doi: 10.1111/apt.17728. PMID: 37750406
Advances in the diagnosis and management of gastroesophageal reflux disease.
Katzka DA, Kahrilas PJ
BMJ 2020 Nov 23;371:m3786. doi: 10.1136/bmj.m3786. PMID: 33229333
Esophageal reflux hypersensitivity: Non-GERD or still GERD?
Savarino V, Marabotto E, Zentilin P, Demarzo MG, Pellegatta G, Frazzoni M, De Bortoli N, Tolone S, Giannini EG, Savarino E
Dig Liver Dis 2020 Dec;52(12):1413-1420. Epub 2020 Oct 21 doi: 10.1016/j.dld.2020.10.003. PMID: 33097427
Complexity and diversity of gastroesophageal reflux disease phenotypes.
Zentilin P, Marabotto E, Pellegatta G, Coppo C, Furnari M, Savarino E, Savarino V
Minerva Gastroenterol Dietol 2017 Sep;63(3):198-204. Epub 2017 Mar 7 doi: 10.23736/S1121-421X.17.02399-6. PMID: 28272380
Epidemiology of non-erosive reflux disease.
El-Serag HB
Digestion 2008;78 Suppl 1:6-10. Epub 2008 Oct 2 doi: 10.1159/000151249. PMID: 18832834

Diagnosis

Evidence-based clinical practice guidelines for gastroesophageal reflux disease 2021.
Iwakiri K, Fujiwara Y, Manabe N, Ihara E, Kuribayashi S, Akiyama J, Kondo T, Yamashita H, Ishimura N, Kitasako Y, Iijima K, Koike T, Omura N, Nomura T, Kawamura O, Ohara S, Ozawa S, Kinoshita Y, Mochida S, Enomoto N, Shimosegawa T, Koike K
J Gastroenterol 2022 Apr;57(4):267-285. Epub 2022 Feb 28 doi: 10.1007/s00535-022-01861-z. PMID: 35226174Free PMC Article
Gastro-oesophageal reflux disease.
Fass R, Boeckxstaens GE, El-Serag H, Rosen R, Sifrim D, Vaezi MF
Nat Rev Dis Primers 2021 Jul 29;7(1):55. doi: 10.1038/s41572-021-00287-w. PMID: 34326345
Advances in the diagnosis and management of gastroesophageal reflux disease.
Katzka DA, Kahrilas PJ
BMJ 2020 Nov 23;371:m3786. doi: 10.1136/bmj.m3786. PMID: 33229333
Reflux Hypersensitivity: How to Approach Diagnosis and Management.
Aggarwal P, Kamal AN
Curr Gastroenterol Rep 2020 Jul 10;22(9):42. doi: 10.1007/s11894-020-00779-x. PMID: 32651667
Gastro-oesophageal reflux disease.
Moayyedi P, Talley NJ
Lancet 2006 Jun 24;367(9528):2086-100. doi: 10.1016/S0140-6736(06)68932-0. PMID: 16798392

Therapy

A systematic review and meta-analysis of the efficacy of vonoprazan for proton pump inhibitor-resistant gastroesophageal reflux disease.
Simadibrata DM, Lesmana E, Fass R
J Gastroenterol Hepatol 2024 May;39(5):796-805. Epub 2024 Jan 23 doi: 10.1111/jgh.16475. PMID: 38263507
Proton pump inhibitor-induced gut dysbiosis and immunomodulation: current knowledge and potential restoration by probiotics.
Kiecka A, Szczepanik M
Pharmacol Rep 2023 Aug;75(4):791-804. Epub 2023 May 4 doi: 10.1007/s43440-023-00489-x. PMID: 37142877Free PMC Article
Evidence-based clinical practice guidelines for gastroesophageal reflux disease 2021.
Iwakiri K, Fujiwara Y, Manabe N, Ihara E, Kuribayashi S, Akiyama J, Kondo T, Yamashita H, Ishimura N, Kitasako Y, Iijima K, Koike T, Omura N, Nomura T, Kawamura O, Ohara S, Ozawa S, Kinoshita Y, Mochida S, Enomoto N, Shimosegawa T, Koike K
J Gastroenterol 2022 Apr;57(4):267-285. Epub 2022 Feb 28 doi: 10.1007/s00535-022-01861-z. PMID: 35226174Free PMC Article
Gastro-oesophageal reflux disease.
Fass R, Boeckxstaens GE, El-Serag H, Rosen R, Sifrim D, Vaezi MF
Nat Rev Dis Primers 2021 Jul 29;7(1):55. doi: 10.1038/s41572-021-00287-w. PMID: 34326345
Advances in the diagnosis and management of gastroesophageal reflux disease.
Katzka DA, Kahrilas PJ
BMJ 2020 Nov 23;371:m3786. doi: 10.1136/bmj.m3786. PMID: 33229333

Prognosis

Visceral fat thickness of erosive and non-erosive reflux disease subjects in Indonesia's tertiary referral hospital.
Nurleili RA, Purnamasari D, Simadibrata M, Rachman A, Tahapary DL, Gani RA
Diabetes Metab Syndr 2019 May-Jun;13(3):1929-1933. Epub 2019 Apr 20 doi: 10.1016/j.dsx.2019.04.025. PMID: 31235117
Proton Pump Inhibitors in Gastroesophageal Reflux Disease: Friend or Foe.
Gyawali CP
Curr Gastroenterol Rep 2017 Sep;19(9):46. doi: 10.1007/s11894-017-0586-5. PMID: 28780717
Changes in the esophageal mucosa of patients with non erosive reflux disease: How far have we gone?
Triantos C, Koukias N, Karamanolis G, Thomopoulos K
World J Gastroenterol 2015 May 21;21(19):5762-7. doi: 10.3748/wjg.v21.i19.5762. PMID: 26019440Free PMC Article
Gastroesophageal reflux disease: Update on inflammation and symptom perception.
Altomare A, Guarino MP, Cocca S, Emerenziani S, Cicala M
World J Gastroenterol 2013 Oct 21;19(39):6523-8. doi: 10.3748/wjg.v19.i39.6523. PMID: 24151376Free PMC Article
Epidemiology of non-erosive reflux disease.
El-Serag HB
Digestion 2008;78 Suppl 1:6-10. Epub 2008 Oct 2 doi: 10.1159/000151249. PMID: 18832834

Clinical prediction guides

A systematic review and meta-analysis of the efficacy of vonoprazan for proton pump inhibitor-resistant gastroesophageal reflux disease.
Simadibrata DM, Lesmana E, Fass R
J Gastroenterol Hepatol 2024 May;39(5):796-805. Epub 2024 Jan 23 doi: 10.1111/jgh.16475. PMID: 38263507
Differences in Dietary and Lifestyle Triggers between Non-Erosive Reflux Disease and Reflux Esophagitis-A Multicenter Cross-Sectional Survey in China.
Chen Y, Sun X, Fan W, Yu J, Wang P, Liu D, Song M, Liu S, Zuo X, Zhang R, Hou Y, Han S, Li Y, Zhang J, Li X, Ke M, Fang X
Nutrients 2023 Jul 31;15(15) doi: 10.3390/nu15153400. PMID: 37571337Free PMC Article
Clinical Characterization of Vonoprazan-Refractory Gastroesophageal Reflux Disease.
Hamada S, Ihara E, Ikeda H, Muta K, Ogino H, Chinen T, Tanaka Y, Ogawa Y
Digestion 2021;102(2):197-204. Epub 2019 Oct 2 doi: 10.1159/000503340. PMID: 31578027
Medical treatment of gastroesophageal reflux disease.
Bor S, Kalkan İH
Turk J Gastroenterol 2017 Dec;28(Suppl 1):S48-S52. doi: 10.5152/tjg.2017.13. PMID: 29199168
Evidence-based clinical practice guidelines for gastroesophageal reflux disease 2015.
Iwakiri K, Kinoshita Y, Habu Y, Oshima T, Manabe N, Fujiwara Y, Nagahara A, Kawamura O, Iwakiri R, Ozawa S, Ashida K, Ohara S, Kashiwagi H, Adachi K, Higuchi K, Miwa H, Fujimoto K, Kusano M, Hoshihara Y, Kawano T, Haruma K, Hongo M, Sugano K, Watanabe M, Shimosegawa T
J Gastroenterol 2016 Aug;51(8):751-67. Epub 2016 Jun 21 doi: 10.1007/s00535-016-1227-8. PMID: 27325300

Recent systematic reviews

A systematic review and meta-analysis of the efficacy of vonoprazan for proton pump inhibitor-resistant gastroesophageal reflux disease.
Simadibrata DM, Lesmana E, Fass R
J Gastroenterol Hepatol 2024 May;39(5):796-805. Epub 2024 Jan 23 doi: 10.1111/jgh.16475. PMID: 38263507
The role of histology in the diagnosis of non-erosive reflux disease: A systematic review and meta-analysis.
Kataria J, Rivera D, Grin A, Reed DE, Rodrigues DM
Neurogastroenterol Motil 2023 Dec;35(12):e14631. Epub 2023 Jul 13 doi: 10.1111/nmo.14631. PMID: 37448170
Systematic review: duodenogastroesophageal (biliary) reflux prevalence, symptoms, oesophageal lesions and treatment.
Basnayake C, Geeraerts A, Pauwels A, Koek G, Vaezi M, Vanuytsel T, Tack J
Aliment Pharmacol Ther 2021 Sep;54(6):755-778. Epub 2021 Jul 27 doi: 10.1111/apt.16533. PMID: 34313333
Alginate therapy is effective treatment for gastroesophageal reflux disease symptoms: a systematic review and meta-analysis.
Leiman DA, Riff BP, Morgan S, Metz DC, Falk GW, French B, Umscheid CA, Lewis JD
Dis Esophagus 2017 Feb 1;30(2):1-8. doi: 10.1111/dote.12535. PMID: 27671545
Systematic review: maintenance treatment of gastro-oesophageal reflux disease with proton pump inhibitors taken 'on-demand'.
Pace F, Tonini M, Pallotta S, Molteni P, Porro GB
Aliment Pharmacol Ther 2007 Jul 15;26(2):195-204. doi: 10.1111/j.1365-2036.2007.03381.x. PMID: 17593065

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