U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Subclinical hyperthyroidism

MedGen UID:
745057
•Concept ID:
C1998045
•
Disease or Syndrome
SNOMED CT: Subclinical hyperthyroidism (427970008)

Professional guidelines

PubMed

Subclinical Hyperthyroidism: When to Consider Treatment.
Donangelo I, Suh SY
Am Fam Physician 2017 Jun 1;95(11):710-716. PMID: 28671443
2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis.
Ross DS, Burch HB, Cooper DS, Greenlee MC, Laurberg P, Maia AL, Rivkees SA, Samuels M, Sosa JA, Stan MN, Walter MA
Thyroid 2016 Oct;26(10):1343-1421. doi: 10.1089/thy.2016.0229. PMID: 27521067
Hyperthyroidism and other causes of thyrotoxicosis: management guidelines of the American Thyroid Association and American Association of Clinical Endocrinologists.
Bahn Chair RS, Burch HB, Cooper DS, Garber JR, Greenlee MC, Klein I, Laurberg P, McDougall IR, Montori VM, Rivkees SA, Ross DS, Sosa JA, Stan MN; American Thyroid Association; American Association of Clinical Endocrinologists
Thyroid 2011 Jun;21(6):593-646. Epub 2011 Apr 21 doi: 10.1089/thy.2010.0417. PMID: 21510801

Recent clinical studies

Etiology

Hyperthyroidism: A Review.
Lee SY, Pearce EN
JAMA 2023 Oct 17;330(15):1472-1483. doi: 10.1001/jama.2023.19052. PMID: 37847271Free PMC Article
Atrial fibrillation and hyperthyroidism: A literature review.
Reddy V, Taha W, Kundumadam S, Khan M
Indian Heart J 2017 Jul-Aug;69(4):545-550. Epub 2017 Jul 5 doi: 10.1016/j.ihj.2017.07.004. PMID: 28822529Free PMC Article
Hyperthyroidism and the Heart.
Osuna PM, Udovcic M, Sharma MD
Methodist Debakey Cardiovasc J 2017 Apr-Jun;13(2):60-63. doi: 10.14797/mdcj-13-2-60. PMID: 28740583Free PMC Article
2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis.
Ross DS, Burch HB, Cooper DS, Greenlee MC, Laurberg P, Maia AL, Rivkees SA, Samuels M, Sosa JA, Stan MN, Walter MA
Thyroid 2016 Oct;26(10):1343-1421. doi: 10.1089/thy.2016.0229. PMID: 27521067
Subclinical thyroid disease.
Cooper DS, Biondi B
Lancet 2012 Mar 24;379(9821):1142-54. Epub 2012 Jan 23 doi: 10.1016/S0140-6736(11)60276-6. PMID: 22273398

Diagnosis

Hyperthyroidism.
Chaker L, Cooper DS, Walsh JP, Peeters RP
Lancet 2024 Feb 24;403(10428):768-780. Epub 2024 Jan 23 doi: 10.1016/S0140-6736(23)02016-0. PMID: 38278171
Hyperthyroidism: A Review.
Lee SY, Pearce EN
JAMA 2023 Oct 17;330(15):1472-1483. doi: 10.1001/jama.2023.19052. PMID: 37847271Free PMC Article
Thyrotoxicosis.
Inman BL, Long B
Emerg Med Clin North Am 2023 Nov;41(4):759-774. Epub 2023 Jul 28 doi: 10.1016/j.emc.2023.06.005. PMID: 37758422
Hyperthyroidism and the Heart.
Osuna PM, Udovcic M, Sharma MD
Methodist Debakey Cardiovasc J 2017 Apr-Jun;13(2):60-63. doi: 10.14797/mdcj-13-2-60. PMID: 28740583Free PMC Article
2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis.
Ross DS, Burch HB, Cooper DS, Greenlee MC, Laurberg P, Maia AL, Rivkees SA, Samuels M, Sosa JA, Stan MN, Walter MA
Thyroid 2016 Oct;26(10):1343-1421. doi: 10.1089/thy.2016.0229. PMID: 27521067

Therapy

Hyperthyroidism.
Chaker L, Cooper DS, Walsh JP, Peeters RP
Lancet 2024 Feb 24;403(10428):768-780. Epub 2024 Jan 23 doi: 10.1016/S0140-6736(23)02016-0. PMID: 38278171
Hyperthyroidism: A Review.
Lee SY, Pearce EN
JAMA 2023 Oct 17;330(15):1472-1483. doi: 10.1001/jama.2023.19052. PMID: 37847271Free PMC Article
Update on subclinical thyroid dysfunction.
Hashimoto K
Endocr J 2022 Jul 28;69(7):725-738. Epub 2022 Jun 22 doi: 10.1507/endocrj.EJ22-0182. PMID: 35732440
2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis.
Ross DS, Burch HB, Cooper DS, Greenlee MC, Laurberg P, Maia AL, Rivkees SA, Samuels M, Sosa JA, Stan MN, Walter MA
Thyroid 2016 Oct;26(10):1343-1421. doi: 10.1089/thy.2016.0229. PMID: 27521067
Subclinical thyroid disease.
Cooper DS, Biondi B
Lancet 2012 Mar 24;379(9821):1142-54. Epub 2012 Jan 23 doi: 10.1016/S0140-6736(11)60276-6. PMID: 22273398

Prognosis

Hyperthyroidism.
Chaker L, Cooper DS, Walsh JP, Peeters RP
Lancet 2024 Feb 24;403(10428):768-780. Epub 2024 Jan 23 doi: 10.1016/S0140-6736(23)02016-0. PMID: 38278171
Thyroid Function Within the Normal Range, Subclinical Hypothyroidism, and the Risk of Atrial Fibrillation.
Baumgartner C, da Costa BR, Collet TH, Feller M, Floriani C, Bauer DC, Cappola AR, Heckbert SR, Ceresini G, Gussekloo J, den Elzen WPJ, Peeters RP, Luben R, Völzke H, Dörr M, Walsh JP, Bremner A, Iacoviello M, Macfarlane P, Heeringa J, Stott DJ, Westendorp RGJ, Khaw KT, Magnani JW, Aujesky D, Rodondi N; Thyroid Studies Collaboration
Circulation 2017 Nov 28;136(22):2100-2116. Epub 2017 Oct 23 doi: 10.1161/CIRCULATIONAHA.117.028753. PMID: 29061566Free PMC Article
Atrial fibrillation and hyperthyroidism: A literature review.
Reddy V, Taha W, Kundumadam S, Khan M
Indian Heart J 2017 Jul-Aug;69(4):545-550. Epub 2017 Jul 5 doi: 10.1016/j.ihj.2017.07.004. PMID: 28822529Free PMC Article
Hyperthyroidism and the Heart.
Osuna PM, Udovcic M, Sharma MD
Methodist Debakey Cardiovasc J 2017 Apr-Jun;13(2):60-63. doi: 10.14797/mdcj-13-2-60. PMID: 28740583Free PMC Article
Thyroid Function and Metabolic Syndrome: A Population-Based Thyroid Study.
Mehran L, Amouzegar A, Rahimabad PK, Tohidi M, Tahmasebinejad Z, Azizi F
Horm Metab Res 2017 Mar;49(3):192-200. Epub 2017 Mar 28 doi: 10.1055/s-0042-117279. PMID: 28351085

Clinical prediction guides

Hyperthyroidism: A Review.
Lee SY, Pearce EN
JAMA 2023 Oct 17;330(15):1472-1483. doi: 10.1001/jama.2023.19052. PMID: 37847271Free PMC Article
Association between maternal thyroid function and risk of gestational hypertension and pre-eclampsia: a systematic review and individual-participant data meta-analysis.
Toloza FJK, Derakhshan A, Männistö T, Bliddal S, Popova PV, Carty DM, Chen L, Taylor P, Mosso L, Oken E, Suvanto E, Itoh S, Kishi R, Bassols J, Auvinen J, López-Bermejo A, Brown SJ, Boucai L, Hisada A, Yoshinaga J, Shilova E, Grineva EN, Vrijkotte TGM, Sunyer J, Jiménez-Zabala A, Riaño-Galan I, Lopez-Espinosa MJ, Prokop LJ, Singh Ospina N, Brito JP, Rodriguez-Gutierrez R, Alexander EK, Chaker L, Pearce EN, Peeters RP, Feldt-Rasmussen U, Guxens M, Chatzi L, Delles C, Roeters van Lennep JE, Pop VJM, Lu X, Walsh JP, Nelson SM, Korevaar TIM, Maraka S
Lancet Diabetes Endocrinol 2022 Apr;10(4):243-252. Epub 2022 Mar 4 doi: 10.1016/S2213-8587(22)00007-9. PMID: 35255260Free PMC Article
Subclinical Hyperthyroidism: A Review of the Clinical Literature.
Tsai K, Leung AM
Endocr Pract 2021 Mar;27(3):254-260. Epub 2021 Feb 13 doi: 10.1016/j.eprac.2021.02.002. PMID: 33588063
Thyroid Function Within the Normal Range, Subclinical Hypothyroidism, and the Risk of Atrial Fibrillation.
Baumgartner C, da Costa BR, Collet TH, Feller M, Floriani C, Bauer DC, Cappola AR, Heckbert SR, Ceresini G, Gussekloo J, den Elzen WPJ, Peeters RP, Luben R, Völzke H, Dörr M, Walsh JP, Bremner A, Iacoviello M, Macfarlane P, Heeringa J, Stott DJ, Westendorp RGJ, Khaw KT, Magnani JW, Aujesky D, Rodondi N; Thyroid Studies Collaboration
Circulation 2017 Nov 28;136(22):2100-2116. Epub 2017 Oct 23 doi: 10.1161/CIRCULATIONAHA.117.028753. PMID: 29061566Free PMC Article
Atrial fibrillation and hyperthyroidism: A literature review.
Reddy V, Taha W, Kundumadam S, Khan M
Indian Heart J 2017 Jul-Aug;69(4):545-550. Epub 2017 Jul 5 doi: 10.1016/j.ihj.2017.07.004. PMID: 28822529Free PMC Article

Recent systematic reviews

Heart Rate Variability in Hyperthyroidism: A Systematic Review and Meta-Analysis.
Brusseau V, Tauveron I, Bagheri R, Ugbolue UC, Magnon V, Bouillon-Minois JB, Navel V, Dutheil F
Int J Environ Res Public Health 2022 Mar 18;19(6) doi: 10.3390/ijerph19063606. PMID: 35329294Free PMC Article
Association between maternal thyroid function and risk of gestational hypertension and pre-eclampsia: a systematic review and individual-participant data meta-analysis.
Toloza FJK, Derakhshan A, Männistö T, Bliddal S, Popova PV, Carty DM, Chen L, Taylor P, Mosso L, Oken E, Suvanto E, Itoh S, Kishi R, Bassols J, Auvinen J, López-Bermejo A, Brown SJ, Boucai L, Hisada A, Yoshinaga J, Shilova E, Grineva EN, Vrijkotte TGM, Sunyer J, Jiménez-Zabala A, Riaño-Galan I, Lopez-Espinosa MJ, Prokop LJ, Singh Ospina N, Brito JP, Rodriguez-Gutierrez R, Alexander EK, Chaker L, Pearce EN, Peeters RP, Feldt-Rasmussen U, Guxens M, Chatzi L, Delles C, Roeters van Lennep JE, Pop VJM, Lu X, Walsh JP, Nelson SM, Korevaar TIM, Maraka S
Lancet Diabetes Endocrinol 2022 Apr;10(4):243-252. Epub 2022 Mar 4 doi: 10.1016/S2213-8587(22)00007-9. PMID: 35255260Free PMC Article
Higher thyroid hormone levels and cancer.
Petranović Ovčariček P, Verburg FA, Hoffmann M, Iakovou I, Mihailovic J, Vrachimis A, Luster M, Giovanella L
Eur J Nucl Med Mol Imaging 2021 Mar;48(3):808-821. Epub 2020 Sep 18 doi: 10.1007/s00259-020-05018-z. PMID: 32944783
Thyroid Function Within the Normal Range, Subclinical Hypothyroidism, and the Risk of Atrial Fibrillation.
Baumgartner C, da Costa BR, Collet TH, Feller M, Floriani C, Bauer DC, Cappola AR, Heckbert SR, Ceresini G, Gussekloo J, den Elzen WPJ, Peeters RP, Luben R, Völzke H, Dörr M, Walsh JP, Bremner A, Iacoviello M, Macfarlane P, Heeringa J, Stott DJ, Westendorp RGJ, Khaw KT, Magnani JW, Aujesky D, Rodondi N; Thyroid Studies Collaboration
Circulation 2017 Nov 28;136(22):2100-2116. Epub 2017 Oct 23 doi: 10.1161/CIRCULATIONAHA.117.028753. PMID: 29061566Free PMC Article
Hyperthyroidism (primary).
Nygaard B
BMJ Clin Evid 2010 Jul 19;2010 PMID: 21418670Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...