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Capillary infantile hemangioma

MedGen UID:
355573
Concept ID:
C1865871
Disease or Syndrome
Synonyms: Hemangioma, capillary infantile, somatic; Hemangioma, Hereditary; HEMANGIOMA, HEREDITARY CAPILLARY; Hereditary capillary infantile hemangioma
 
Genes (locations): ANTXR1 (2p13.3); FLT4 (5q35.3); KDR (4q12)
 
Monarch Initiative: MONDO:0011191
OMIM®: 602089

Definition

Capillary hemangiomas are benign, highly proliferative lesions involving aberrant localized growth of capillary endothelium. They are the most common tumor of infancy, occurring in up to 10% of all births (Mulliken and Young, 1988). Hemangiomas tend to appear shortly after birth and show rapid neonatal growth for up to 12 months characterized by endothelial hypercellularity and increased numbers of mast cells. This phase is followed by slow involution at a rate of about 10% per year and replacement by fibrofatty stroma. Hemangiomas are classified as distinct from vascular malformations (see, e.g., CMC1, 163000; 108010; and CCM, 116860), in that the latter are present from birth, tend to grow with the individual, do not regress, and show normal rates of endothelial cell turnover (Spring and Bentz, 2005; Legiehn and Heran, 2006). Legiehn and Heran (2006) noted that the term 'hemangioma' in adults is considered inaccurate and should be discarded. Most hemangiomas occur sporadically, but some families with autosomal dominant inheritance have been reported (Walter et al., 1999). [from OMIM]

Clinical features

From HPO
Capillary hemangioma
MedGen UID:
64643
Concept ID:
C0206733
Neoplastic Process
The presence of a capillary hemangioma, which are hemangiomas with small endothelial spaces.

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
Follow this link to review classifications for Capillary infantile hemangioma in Orphanet.

Professional guidelines

PubMed

Vassallo P, Forte R, Di Mezza A, Magli A
Am J Ophthalmol 2013 Jan;155(1):165-170.e2. Epub 2012 Sep 8 doi: 10.1016/j.ajo.2012.06.021. PMID: 22967870
Ni N, Guo S, Langer P
Curr Opin Ophthalmol 2011 Sep;22(5):419-25. doi: 10.1097/ICU.0b013e32834994b4. PMID: 21730838

Recent clinical studies

Etiology

Pope E, Lara-Corrales I, Sibbald C, Liy-Wong C, Kanigsberg N, Drolet B, Ma J
JAMA Pediatr 2022 Jan 1;176(1):34-41. doi: 10.1001/jamapediatrics.2021.4565. PMID: 34747977Free PMC Article
Sebaratnam DF, Rodríguez Bandera AL, Wong LF, Wargon O
J Am Acad Dermatol 2021 Dec;85(6):1395-1404. Epub 2021 Aug 19 doi: 10.1016/j.jaad.2021.08.020. PMID: 34419523
Ji Y, Chen S, Yang K, Zhang X, Zhou J, Li L, Xiang B, Qiu T, Dai S, Jiang X, Lu G, Qiu L, Kong F, Zhang Y
JAMA Otolaryngol Head Neck Surg 2021 Jul 1;147(7):599-607. doi: 10.1001/jamaoto.2021.0454. PMID: 33856430Free PMC Article
Muñoz-Garza FZ, Ríos M, Roé-Crespo E, Bernabeu-Wittel J, Montserrat-García MT, Puig L, Gich I, Baselga E
JAMA Dermatol 2021 May 1;157(5):583-587. doi: 10.1001/jamadermatol.2021.0596. PMID: 33825828Free PMC Article
Kligerman SJ, Henry T, Lin CT, Franks TJ, Galvin JR
Radiographics 2015 Sep-Oct;35(5):1360-80. Epub 2015 Aug 14 doi: 10.1148/rg.2015140308. PMID: 26274445

Diagnosis

Rodríguez Bandera AI, Sebaratnam DF, Wargon O, Wong LF
J Am Acad Dermatol 2021 Dec;85(6):1379-1392. Epub 2021 Aug 19 doi: 10.1016/j.jaad.2021.08.019. PMID: 34419524
Sebaratnam DF, Rodríguez Bandera AL, Wong LF, Wargon O
J Am Acad Dermatol 2021 Dec;85(6):1395-1404. Epub 2021 Aug 19 doi: 10.1016/j.jaad.2021.08.020. PMID: 34419523
Robinson SK, Jefferson IS, Agidi A, Moy L, Lake E, Kim W
Cutis 2020 Mar;105(3):132-136. PMID: 32352437
Mangold AR, Torgerson RR, Rogers RS 3rd
Clin Dermatol 2016 Jul-Aug;34(4):458-69. Epub 2016 Mar 8 doi: 10.1016/j.clindermatol.2016.02.018. PMID: 27343960
Spence-Shishido AA, Good WV, Baselga E, Frieden IJ
Clin Dermatol 2015 Mar-Apr;33(2):170-82. doi: 10.1016/j.clindermatol.2014.10.009. PMID: 25704937

Therapy

Hasbani DJ, Hamie L
Dermatol Clin 2022 Oct;40(4):383-392. Epub 2022 Sep 16 doi: 10.1016/j.det.2022.06.004. PMID: 36243426
Pope E, Lara-Corrales I, Sibbald C, Liy-Wong C, Kanigsberg N, Drolet B, Ma J
JAMA Pediatr 2022 Jan 1;176(1):34-41. doi: 10.1001/jamapediatrics.2021.4565. PMID: 34747977Free PMC Article
Sebaratnam DF, Rodríguez Bandera AL, Wong LF, Wargon O
J Am Acad Dermatol 2021 Dec;85(6):1395-1404. Epub 2021 Aug 19 doi: 10.1016/j.jaad.2021.08.020. PMID: 34419523
Ji Y, Chen S, Yang K, Zhang X, Zhou J, Li L, Xiang B, Qiu T, Dai S, Jiang X, Lu G, Qiu L, Kong F, Zhang Y
JAMA Otolaryngol Head Neck Surg 2021 Jul 1;147(7):599-607. doi: 10.1001/jamaoto.2021.0454. PMID: 33856430Free PMC Article
Muñoz-Garza FZ, Ríos M, Roé-Crespo E, Bernabeu-Wittel J, Montserrat-García MT, Puig L, Gich I, Baselga E
JAMA Dermatol 2021 May 1;157(5):583-587. doi: 10.1001/jamadermatol.2021.0596. PMID: 33825828Free PMC Article

Prognosis

Al-Ibraheemi A
Surg Pathol Clin 2020 Dec;13(4):719-728. doi: 10.1016/j.path.2020.08.008. PMID: 33183729
Girerd B, Lau E, Montani D, Humbert M
Curr Opin Pulm Med 2017 Sep;23(5):386-391. doi: 10.1097/MCP.0000000000000414. PMID: 28661905
Spence-Shishido AA, Good WV, Baselga E, Frieden IJ
Clin Dermatol 2015 Mar-Apr;33(2):170-82. doi: 10.1016/j.clindermatol.2014.10.009. PMID: 25704937
Lee KC, Bercovitch L
Semin Perinatol 2013 Feb;37(1):49-58. doi: 10.1053/j.semperi.2012.11.003. PMID: 23419763
Spring MA, Bentz ML
Clin Plast Surg 2005 Apr;32(2):171-86. doi: 10.1016/j.cps.2004.11.004. PMID: 15814115

Clinical prediction guides

Mirzayev I, Gündüz AK
Turk J Ophthalmol 2022 Dec 28;52(6):421-431. doi: 10.4274/tjo.galenos.2022.25979. PMID: 36578224Free PMC Article
Lee SH, Park KH, Woo SJ, Park SJ, Joo K
Korean J Ophthalmol 2022 Dec;36(6):543-549. Epub 2022 Oct 25 doi: 10.3341/kjo.2022.0079. PMID: 36281577Free PMC Article
Ji Y, Chen S, Yang K, Zhang X, Zhou J, Li L, Xiang B, Qiu T, Dai S, Jiang X, Lu G, Qiu L, Kong F, Zhang Y
JAMA Otolaryngol Head Neck Surg 2021 Jul 1;147(7):599-607. doi: 10.1001/jamaoto.2021.0454. PMID: 33856430Free PMC Article
Muñoz-Garza FZ, Ríos M, Roé-Crespo E, Bernabeu-Wittel J, Montserrat-García MT, Puig L, Gich I, Baselga E
JAMA Dermatol 2021 May 1;157(5):583-587. doi: 10.1001/jamadermatol.2021.0596. PMID: 33825828Free PMC Article
Saerens J, De Leye H, Janmohamed SR
Clin Exp Dermatol 2021 Apr;46(3):480-486. Epub 2021 Feb 4 doi: 10.1111/ced.14537. PMID: 33539606

Recent systematic reviews

Aziz H, Brown ZJ, Baghdadi A, Kamel IR, Pawlik TM
J Gastrointest Surg 2022 Sep;26(9):1998-2007. Epub 2022 Jun 15 doi: 10.1007/s11605-022-05382-1. PMID: 35705835
Wanitphakdeedecha R, Sudhipongpracha T, Ng JNC, Yan C, Jantarakolica T
J Cosmet Dermatol 2021 Jul;20(7):2203-2210. Epub 2021 May 18 doi: 10.1111/jocd.14199. PMID: 33949094
Novoa M, Baselga E, Beltran S, Giraldo L, Shahbaz A, Pardo-Hernandez H, Arevalo-Rodriguez I
Cochrane Database Syst Rev 2018 Apr 18;4(4):CD006545. doi: 10.1002/14651858.CD006545.pub3. PMID: 29667726Free PMC Article
Chinnadurai S, Sathe NA, Surawicz T
Lasers Surg Med 2016 Mar;48(3):221-33. Epub 2015 Dec 29 doi: 10.1002/lsm.22455. PMID: 26711436
Leonardi-Bee J, Batta K, O'Brien C, Bath-Hextall FJ
Cochrane Database Syst Rev 2011 May 11;(5):CD006545. doi: 10.1002/14651858.CD006545.pub2. PMID: 21563155

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