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Pancreatic cancer, susceptibility to, 1

MedGen UID:
339739
Concept ID:
C1847351
Finding
Synonyms: Pancreatic cancer 1; Pancreatic Cancer Susceptibility 1
 
Gene (location): PALLD (4q32.3)
 
Monarch Initiative: MONDO:0011739
OMIM®: 606856

Definition

Any familial pancreatic carcinoma in which the cause of the disease is a mutation in the PALLD gene. [from MONDO]

Clinical features

From HPO
Pancreatic adenocarcinoma
MedGen UID:
83800
Concept ID:
C0281361
Neoplastic Process
The presence of an adenocarcinoma of the pancreas.

Professional guidelines

PubMed

Li W, Liu JB, Hou LK, Yu F, Zhang J, Wu W, Tang XM, Sun F, Lu HM, Deng J, Bai J, Li J, Wu CY, Lin QL, Lv ZW, Wang GR, Jiang GX, Ma YS, Fu D
Mol Cancer 2022 Jan 20;21(1):25. doi: 10.1186/s12943-022-01505-z. PMID: 35057806Free PMC Article
Daly MB, Pal T, Berry MP, Buys SS, Dickson P, Domchek SM, Elkhanany A, Friedman S, Goggins M, Hutton ML; CGC, Karlan BY, Khan S, Klein C, Kohlmann W; CGC, Kurian AW, Laronga C, Litton JK, Mak JS; LCGC, Menendez CS, Merajver SD, Norquist BS, Offit K, Pederson HJ, Reiser G; CGC, Senter-Jamieson L; CGC, Shannon KM, Shatsky R, Visvanathan K, Weitzel JN, Wick MJ, Wisinski KB, Yurgelun MB, Darlow SD, Dwyer MA
J Natl Compr Canc Netw 2021 Jan 6;19(1):77-102. doi: 10.6004/jnccn.2021.0001. PMID: 33406487
Goggins M, Overbeek KA, Brand R, Syngal S, Del Chiaro M, Bartsch DK, Bassi C, Carrato A, Farrell J, Fishman EK, Fockens P, Gress TM, van Hooft JE, Hruban RH, Kastrinos F, Klein A, Lennon AM, Lucas A, Park W, Rustgi A, Simeone D, Stoffel E, Vasen HFA, Cahen DL, Canto MI, Bruno M; International Cancer of the Pancreas Screening (CAPS) consortium
Gut 2020 Jan;69(1):7-17. Epub 2019 Oct 31 doi: 10.1136/gutjnl-2019-319352. PMID: 31672839Free PMC Article

Recent clinical studies

Etiology

Ettrich TJ, Seufferlein T
Curr Treat Options Oncol 2021 Oct 19;22(11):106. doi: 10.1007/s11864-021-00895-4. PMID: 34665339Free PMC Article
Abe K, Kitago M, Kitagawa Y, Hirasawa A
Int J Clin Oncol 2021 Oct;26(10):1784-1792. Epub 2021 Sep 2 doi: 10.1007/s10147-021-02015-6. PMID: 34476650Free PMC Article
Daly MB, Pal T, Berry MP, Buys SS, Dickson P, Domchek SM, Elkhanany A, Friedman S, Goggins M, Hutton ML; CGC, Karlan BY, Khan S, Klein C, Kohlmann W; CGC, Kurian AW, Laronga C, Litton JK, Mak JS; LCGC, Menendez CS, Merajver SD, Norquist BS, Offit K, Pederson HJ, Reiser G; CGC, Senter-Jamieson L; CGC, Shannon KM, Shatsky R, Visvanathan K, Weitzel JN, Wick MJ, Wisinski KB, Yurgelun MB, Darlow SD, Dwyer MA
J Natl Compr Canc Netw 2021 Jan 6;19(1):77-102. doi: 10.6004/jnccn.2021.0001. PMID: 33406487
Goggins M, Overbeek KA, Brand R, Syngal S, Del Chiaro M, Bartsch DK, Bassi C, Carrato A, Farrell J, Fishman EK, Fockens P, Gress TM, van Hooft JE, Hruban RH, Kastrinos F, Klein A, Lennon AM, Lucas A, Park W, Rustgi A, Simeone D, Stoffel E, Vasen HFA, Cahen DL, Canto MI, Bruno M; International Cancer of the Pancreas Screening (CAPS) consortium
Gut 2020 Jan;69(1):7-17. Epub 2019 Oct 31 doi: 10.1136/gutjnl-2019-319352. PMID: 31672839Free PMC Article
Hu C, Hart SN, Polley EC, Gnanaolivu R, Shimelis H, Lee KY, Lilyquist J, Na J, Moore R, Antwi SO, Bamlet WR, Chaffee KG, DiCarlo J, Wu Z, Samara R, Kasi PM, McWilliams RR, Petersen GM, Couch FJ
JAMA 2018 Jun 19;319(23):2401-2409. doi: 10.1001/jama.2018.6228. PMID: 29922827Free PMC Article

Diagnosis

Li W, Liu JB, Hou LK, Yu F, Zhang J, Wu W, Tang XM, Sun F, Lu HM, Deng J, Bai J, Li J, Wu CY, Lin QL, Lv ZW, Wang GR, Jiang GX, Ma YS, Fu D
Mol Cancer 2022 Jan 20;21(1):25. doi: 10.1186/s12943-022-01505-z. PMID: 35057806Free PMC Article
Abe K, Kitago M, Kitagawa Y, Hirasawa A
Int J Clin Oncol 2021 Oct;26(10):1784-1792. Epub 2021 Sep 2 doi: 10.1007/s10147-021-02015-6. PMID: 34476650Free PMC Article
Daly MB, Pal T, Berry MP, Buys SS, Dickson P, Domchek SM, Elkhanany A, Friedman S, Goggins M, Hutton ML; CGC, Karlan BY, Khan S, Klein C, Kohlmann W; CGC, Kurian AW, Laronga C, Litton JK, Mak JS; LCGC, Menendez CS, Merajver SD, Norquist BS, Offit K, Pederson HJ, Reiser G; CGC, Senter-Jamieson L; CGC, Shannon KM, Shatsky R, Visvanathan K, Weitzel JN, Wick MJ, Wisinski KB, Yurgelun MB, Darlow SD, Dwyer MA
J Natl Compr Canc Netw 2021 Jan 6;19(1):77-102. doi: 10.6004/jnccn.2021.0001. PMID: 33406487
Yoshida R
Breast Cancer 2021 Nov;28(6):1167-1180. Epub 2020 Aug 29 doi: 10.1007/s12282-020-01148-2. PMID: 32862296Free PMC Article
Goggins M, Overbeek KA, Brand R, Syngal S, Del Chiaro M, Bartsch DK, Bassi C, Carrato A, Farrell J, Fishman EK, Fockens P, Gress TM, van Hooft JE, Hruban RH, Kastrinos F, Klein A, Lennon AM, Lucas A, Park W, Rustgi A, Simeone D, Stoffel E, Vasen HFA, Cahen DL, Canto MI, Bruno M; International Cancer of the Pancreas Screening (CAPS) consortium
Gut 2020 Jan;69(1):7-17. Epub 2019 Oct 31 doi: 10.1136/gutjnl-2019-319352. PMID: 31672839Free PMC Article

Therapy

Huntley C, Torr B, Sud A, Rowlands CF, Way R, Snape K, Hanson H, Swanton C, Broggio J, Lucassen A, McCartney M, Houlston RS, Hingorani AD, Jones ME, Turnbull C
Lancet Oncol 2023 Jun;24(6):658-668. Epub 2023 May 10 doi: 10.1016/S1470-2045(23)00156-0. PMID: 37178708
Ettrich TJ, Seufferlein T
Curr Treat Options Oncol 2021 Oct 19;22(11):106. doi: 10.1007/s11864-021-00895-4. PMID: 34665339Free PMC Article
Meng C, Bai C, Brown TD, Hood LE, Tian Q
Genomics Proteomics Bioinformatics 2018 Feb;16(1):33-49. Epub 2018 Feb 21 doi: 10.1016/j.gpb.2017.06.002. PMID: 29474889Free PMC Article
Dimitrakopoulou VI, Tsilidis KK, Haycock PC, Dimou NL, Al-Dabhani K, Martin RM, Lewis SJ, Gunter MJ, Mondul A, Shui IM, Theodoratou E, Nimptsch K, Lindström S, Albanes D, Kühn T, Key TJ, Travis RC, Vimaleswaran KS; GECCO Consortium; PRACTICAL Consortium; GAME-ON Network (CORECT, DRIVE, ELLIPSE, FOCI-OCAC, TRICL-ILCCO), Kraft P, Pierce BL, Schildkraut JM
BMJ 2017 Oct 31;359:j4761. doi: 10.1136/bmj.j4761. PMID: 29089348Free PMC Article
Mandelker D, Zhang L, Kemel Y, Stadler ZK, Joseph V, Zehir A, Pradhan N, Arnold A, Walsh MF, Li Y, Balakrishnan AR, Syed A, Prasad M, Nafa K, Carlo MI, Cadoo KA, Sheehan M, Fleischut MH, Salo-Mullen E, Trottier M, Lipkin SM, Lincoln A, Mukherjee S, Ravichandran V, Cambria R, Galle J, Abida W, Arcila ME, Benayed R, Shah R, Yu K, Bajorin DF, Coleman JA, Leach SD, Lowery MA, Garcia-Aguilar J, Kantoff PW, Sawyers CL, Dickler MN, Saltz L, Motzer RJ, O'Reilly EM, Scher HI, Baselga J, Klimstra DS, Solit DB, Hyman DM, Berger MF, Ladanyi M, Robson ME, Offit K
JAMA 2017 Sep 5;318(9):825-835. doi: 10.1001/jama.2017.11137. PMID: 28873162Free PMC Article

Prognosis

Li W, Liu JB, Hou LK, Yu F, Zhang J, Wu W, Tang XM, Sun F, Lu HM, Deng J, Bai J, Li J, Wu CY, Lin QL, Lv ZW, Wang GR, Jiang GX, Ma YS, Fu D
Mol Cancer 2022 Jan 20;21(1):25. doi: 10.1186/s12943-022-01505-z. PMID: 35057806Free PMC Article
Ettrich TJ, Seufferlein T
Curr Treat Options Oncol 2021 Oct 19;22(11):106. doi: 10.1007/s11864-021-00895-4. PMID: 34665339Free PMC Article
Abe K, Kitago M, Kitagawa Y, Hirasawa A
Int J Clin Oncol 2021 Oct;26(10):1784-1792. Epub 2021 Sep 2 doi: 10.1007/s10147-021-02015-6. PMID: 34476650Free PMC Article
Yoshida R
Breast Cancer 2021 Nov;28(6):1167-1180. Epub 2020 Aug 29 doi: 10.1007/s12282-020-01148-2. PMID: 32862296Free PMC Article
Hu C, Hart SN, Polley EC, Gnanaolivu R, Shimelis H, Lee KY, Lilyquist J, Na J, Moore R, Antwi SO, Bamlet WR, Chaffee KG, DiCarlo J, Wu Z, Samara R, Kasi PM, McWilliams RR, Petersen GM, Couch FJ
JAMA 2018 Jun 19;319(23):2401-2409. doi: 10.1001/jama.2018.6228. PMID: 29922827Free PMC Article

Clinical prediction guides

Momozawa Y, Sasai R, Usui Y, Shiraishi K, Iwasaki Y, Taniyama Y, Parsons MT, Mizukami K, Sekine Y, Hirata M, Kamatani Y, Endo M, Inai C, Takata S, Ito H, Kohno T, Matsuda K, Nakamura S, Sugano K, Yoshida T, Nakagawa H, Matsuo K, Murakami Y, Spurdle AB, Kubo M
JAMA Oncol 2022 Jun 1;8(6):871-878. doi: 10.1001/jamaoncol.2022.0476. PMID: 35420638Free PMC Article
Li W, Liu JB, Hou LK, Yu F, Zhang J, Wu W, Tang XM, Sun F, Lu HM, Deng J, Bai J, Li J, Wu CY, Lin QL, Lv ZW, Wang GR, Jiang GX, Ma YS, Fu D
Mol Cancer 2022 Jan 20;21(1):25. doi: 10.1186/s12943-022-01505-z. PMID: 35057806Free PMC Article
Labib PL, Goodchild G, Pereira SP
BMC Cancer 2019 Feb 28;19(1):185. doi: 10.1186/s12885-019-5391-0. PMID: 30819129Free PMC Article
Hu C, Hart SN, Polley EC, Gnanaolivu R, Shimelis H, Lee KY, Lilyquist J, Na J, Moore R, Antwi SO, Bamlet WR, Chaffee KG, DiCarlo J, Wu Z, Samara R, Kasi PM, McWilliams RR, Petersen GM, Couch FJ
JAMA 2018 Jun 19;319(23):2401-2409. doi: 10.1001/jama.2018.6228. PMID: 29922827Free PMC Article
Nakamura H, Arai Y, Totoki Y, Shirota T, Elzawahry A, Kato M, Hama N, Hosoda F, Urushidate T, Ohashi S, Hiraoka N, Ojima H, Shimada K, Okusaka T, Kosuge T, Miyagawa S, Shibata T
Nat Genet 2015 Sep;47(9):1003-10. Epub 2015 Aug 10 doi: 10.1038/ng.3375. PMID: 26258846

Recent systematic reviews

Mei J, Qian M, Hou Y, Liang M, Chen Y, Wang C, Zhang J
Lipids Health Dis 2024 Jan 30;23(1):32. doi: 10.1186/s12944-024-02025-z. PMID: 38291432Free PMC Article
Feng Z, Yang X, Tian M, Zeng N, Bai Z, Deng W, Zhao Y, Guo J, Yang Y, Zhang Z, Yang Y
BMC Cancer 2023 Aug 29;23(1):807. doi: 10.1186/s12885-023-11328-w. PMID: 37644384Free PMC Article
Stoffel EM, McKernin SE, Brand R, Canto M, Goggins M, Moravek C, Nagarajan A, Petersen GM, Simeone DM, Yurgelun M, Khorana AA
J Clin Oncol 2019 Jan 10;37(2):153-164. Epub 2018 Nov 20 doi: 10.1200/JCO.18.01489. PMID: 30457921
Benna C, Helfrich-Förster C, Rajendran S, Monticelli H, Pilati P, Nitti D, Mocellin S
Oncotarget 2017 Apr 4;8(14):23978-23995. doi: 10.18632/oncotarget.15074. PMID: 28177907Free PMC Article
Ciliberto D, Staropoli N, Chiellino S, Botta C, Tassone P, Tagliaferri P
Pancreatology 2016 Mar-Apr;16(2):249-58. Epub 2016 Jan 20 doi: 10.1016/j.pan.2016.01.003. PMID: 26852170

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