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Mycobacterium tuberculosis, susceptibility to

MedGen UID:
320428
Concept ID:
C1834752
Finding
Synonym: MYCOBACTERIUM TUBERCULOSIS, SUSCEPTIBILITY TO
 
Genes (locations): CCL2 (17q12); CD209 (19p13.2); CISH (3p21.2); IFNG (12q15); IFNGR1 (6q23.3); IRGM (5q33.1); SLC11A1 (2q35); SP110 (2q37.1); TIRAP (11q24.2); TLR2 (4q31.3)
 
OMIM®: 607948

Definition

Mycobacterium tuberculosis latently infects approximately one-third of humanity and is comparable only to human immunodeficiency virus (HIV; see 609423) as a leading infectious cause of mortality worldwide. Obstacles for controlling TB infection include lengthy treatment regimens of 6 to 9 months, drug resistance, lack of a highly efficacious vaccine, and incomplete understanding of the factors that control infectivity and disease progression. Although only 10% of individuals infected with M. tuberculosis develop active disease, the immune responses associated with TB susceptibility or resistance are not known. In addition, it is not known why some individuals have disseminated TB that spreads to the meninges and central nervous system, while most people have localized disease in the lungs. A number of studies suggest that host genetic factors influence susceptibility and resistance to TB (review by Berrington and Hawn, 2007). [from OMIM]

Professional guidelines

PubMed

Eribo OA, du Plessis N, Ozturk M, Guler R, Walzl G, Chegou NN
Cell Mol Life Sci 2020 Apr;77(8):1497-1509. Epub 2019 Nov 15 doi: 10.1007/s00018-019-03370-4. PMID: 31729564Free PMC Article
Velayutham BR, Nair D, Chandrasekaran V, Raman B, Sekar G, Watson B, Charles N, Malaisamy M, Thomas A, Swaminathan S
PLoS One 2014;9(3):e88045. Epub 2014 Mar 11 doi: 10.1371/journal.pone.0088045. PMID: 24618888Free PMC Article
Luong Kv, Nguyen LT
Am J Med Sci 2011 Jun;341(6):493-8. doi: 10.1097/MAJ.0b013e3182070f47. PMID: 21289501

Recent clinical studies

Etiology

Velásquez GE, Calderon RI, Mitnick CD, Becerra MC, Huang CC, Zhang Z, Contreras CC, Yataco RM, Galea JT, Lecca LW, Murray MB
Antimicrob Agents Chemother 2016 Nov;60(11):6766-6773. Epub 2016 Oct 21 doi: 10.1128/AAC.00632-16. PMID: 27600032Free PMC Article
Velayutham BR, Nair D, Chandrasekaran V, Raman B, Sekar G, Watson B, Charles N, Malaisamy M, Thomas A, Swaminathan S
PLoS One 2014;9(3):e88045. Epub 2014 Mar 11 doi: 10.1371/journal.pone.0088045. PMID: 24618888Free PMC Article
Kurbatova EV, Cavanaugh JS, Shah NS, Wright A, Kim H, Metchock B, Van Deun A, Barrera L, Boulahbal F, Richter E, Martín-Casabona N, Arias F, Zemanova I, Drobniewski F, Santos Silva A, Coulter C, Lumb R, Cegielski JP
Int J Tuberc Lung Dis 2012;16(3):355-7. doi: 10.5588/ijtld.11.0542. PMID: 22640449Free PMC Article
Kam KM, Yip CW
Int J Tuberc Lung Dis 2004 Jun;8(6):760-6. PMID: 15182147

Diagnosis

Isakova J, Sovkhozova N, Vinnikov D, Goncharova Z, Talaibekova E, Aldasheva N, Aldashev A
BMC Microbiol 2018 Mar 22;18(1):22. doi: 10.1186/s12866-018-1168-x. PMID: 29566660Free PMC Article
Velásquez GE, Calderon RI, Mitnick CD, Becerra MC, Huang CC, Zhang Z, Contreras CC, Yataco RM, Galea JT, Lecca LW, Murray MB
Antimicrob Agents Chemother 2016 Nov;60(11):6766-6773. Epub 2016 Oct 21 doi: 10.1128/AAC.00632-16. PMID: 27600032Free PMC Article
Velayutham BR, Nair D, Chandrasekaran V, Raman B, Sekar G, Watson B, Charles N, Malaisamy M, Thomas A, Swaminathan S
PLoS One 2014;9(3):e88045. Epub 2014 Mar 11 doi: 10.1371/journal.pone.0088045. PMID: 24618888Free PMC Article
Kurbatova EV, Cavanaugh JS, Shah NS, Wright A, Kim H, Metchock B, Van Deun A, Barrera L, Boulahbal F, Richter E, Martín-Casabona N, Arias F, Zemanova I, Drobniewski F, Santos Silva A, Coulter C, Lumb R, Cegielski JP
Int J Tuberc Lung Dis 2012;16(3):355-7. doi: 10.5588/ijtld.11.0542. PMID: 22640449Free PMC Article
Scarparo C, Ricordi P, Ruggiero G, Piccoli P
J Clin Microbiol 2004 Mar;42(3):1109-14. doi: 10.1128/JCM.42.3.1109-1114.2004. PMID: 15004061Free PMC Article

Therapy

Elhassan MM, Hemeg HA, Elmekki MA, Turkistani KA, Abdul-Aziz AA
Infect Disord Drug Targets 2017;17(1):14-23. doi: 10.2174/1871526517666161116104242. PMID: 27848902Free PMC Article
Velásquez GE, Calderon RI, Mitnick CD, Becerra MC, Huang CC, Zhang Z, Contreras CC, Yataco RM, Galea JT, Lecca LW, Murray MB
Antimicrob Agents Chemother 2016 Nov;60(11):6766-6773. Epub 2016 Oct 21 doi: 10.1128/AAC.00632-16. PMID: 27600032Free PMC Article
Velayutham BR, Nair D, Chandrasekaran V, Raman B, Sekar G, Watson B, Charles N, Malaisamy M, Thomas A, Swaminathan S
PLoS One 2014;9(3):e88045. Epub 2014 Mar 11 doi: 10.1371/journal.pone.0088045. PMID: 24618888Free PMC Article
Kam KM, Yip CW
Int J Tuberc Lung Dis 2004 Jun;8(6):760-6. PMID: 15182147

Clinical prediction guides

Scarparo C, Ricordi P, Ruggiero G, Piccoli P
J Clin Microbiol 2004 Mar;42(3):1109-14. doi: 10.1128/JCM.42.3.1109-1114.2004. PMID: 15004061Free PMC Article

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