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Oxyphilic adenoma

MedGen UID:
307150
•Concept ID:
C1510502
•
Neoplastic Process
Synonyms: Oncocytic adenoma; Oncocytoma
SNOMED CT: Oxyphilic adenoma (89439007); Oncocytic adenoma (89439007); Oncocytoma (89439007); Follicular adenoma, oxyphilic cell (89439007)
 
Monarch Initiative: MONDO:0003424
OMIM®: 553000

Definition

Oncocytomas are usually benign tumors that occur in various organs but particularly in the kidneys. Histologic evaluation of renal oncocytomas shows that they are composed entirely of peculiar epithelial cells with granular eosinophilic cytoplasm. Ultrastructural characterization exhibits densely packed cells with mitochondria, which show morphologic differences from those in normal cells. On the average they are larger than those in renal carcinoma cells and their shape is abnormal (summary by Welter et al., 1989). [from OMIM]

Clinical features

From HPO
Oncocytoma of kidney
MedGen UID:
91094
•Concept ID:
C0346255
•
Neoplastic Process
A renal tumor originating from an oncocyte, which is an epithelial cell characterized by an excessive amount of mitochondria, resulting in an abundant acidophilic, granular cytoplasm.
See: Feature record | Search on this feature

Professional guidelines

PubMed

Fine needle aspiration biopsy in the preoperative management of patients with thyroid nodules.
Giovagnoli MR, Pisani T, Drusco A, Scardella L, Antonaci A, Vecchione A
Anticancer Res 1998 Sep-Oct;18(5B):3741-5. PMID: 9854487

Recent clinical studies

Etiology

Molecular Alterations and Comprehensive Clinical Management of Oncocytic Thyroid Carcinoma: A Review and Multidisciplinary 2023 Update.
Bischoff LA, Ganly I, Fugazzola L, Buczek E, Faquin WC, Haugen BR, McIver B, McMullen CP, Newbold K, Rocke DJ, Russell MD, Ryder M, Sadow PM, Sherman E, Shindo M, Shonka DC Jr, Singer MC, Stack BC Jr, Wirth LJ, Wong RJ, Randolph GW
JAMA Otolaryngol Head Neck Surg 2024 Mar 1;150(3):265-272. doi: 10.1001/jamaoto.2023.4323. PMID: 38206595
Short Review: Genomic Alterations in Hürthle Cell Carcinoma.
Ganly I, McFadden DG
Thyroid 2019 Apr;29(4):471-479. doi: 10.1089/thy.2019.0088. PMID: 30848171
Thyroid oncocytic neoplasms.
Doghri R, Znaidi N, Blel A, Aloui R, Lahyeni R, Ben Salah M, Rammeh S
Tunis Med 2018 Mar;96(3):219-223. PMID: 30325491
Molecular profiles of oxyphilic and chief cell parathyroid adenoma.
Lu M, Kjellin H, Fotouhi O, Lee L, Nilsson IL, Haglund F, Höög A, Lehtiö J, Larsson C
Mol Cell Endocrinol 2018 Jul 15;470:84-95. Epub 2017 Oct 3 doi: 10.1016/j.mce.2017.10.001. PMID: 28986304
Oncocytic tumours.
Tallini G
Virchows Arch 1998 Jul;433(1):5-12. doi: 10.1007/s004280050209. PMID: 9692819

Diagnosis

Oncocytic Parathyroid Adenoma.
McCarthy M, Whaley RD, Erickson LA
Mayo Clin Proc 2022 Nov;97(11):2168-2169. doi: 10.1016/j.mayocp.2022.09.015. PMID: 36333022
Genetics, Diagnosis, and Management of Hürthle Cell Thyroid Neoplasms.
McFadden DG, Sadow PM
Front Endocrinol (Lausanne) 2021;12:696386. Epub 2021 Jun 10 doi: 10.3389/fendo.2021.696386. PMID: 34177816Free PMC Article
Thyroid oncocytic neoplasms.
Doghri R, Znaidi N, Blel A, Aloui R, Lahyeni R, Ben Salah M, Rammeh S
Tunis Med 2018 Mar;96(3):219-223. PMID: 30325491
Renal oncocytosis.
Bhatt K, Remer EM, Goldfarb D
J Urol 2014 Oct;192(4):1225-6. Epub 2014 Jul 18 doi: 10.1016/j.juro.2014.07.018. PMID: 25046601
Follicular thyroid carcinoma.
Sobrinho-Simões M, Eloy C, Magalhães J, Lobo C, Amaro T
Mod Pathol 2011 Apr;24 Suppl 2:S10-8. doi: 10.1038/modpathol.2010.133. PMID: 21455197

Therapy

Psammomatous calcifications in thyroid oncocytic (Hürthle cell) follicular tumors.
Ronen N, Suster D
Ann Diagn Pathol 2023 Feb;62:152061. Epub 2022 Nov 22 doi: 10.1016/j.anndiagpath.2022.152061. PMID: 36459776
Primary cell cultures for the personalized therapy in aggressive thyroid cancer of follicular origin.
Fallahi P, Ferrari SM, Elia G, Ragusa F, Patrizio A, Paparo SR, Marone G, Galdiero MR, Guglielmi G, Foddis R, Cristaudo A, Antonelli A
Semin Cancer Biol 2022 Feb;79:203-216. Epub 2020 Jun 20 doi: 10.1016/j.semcancer.2020.06.013. PMID: 32569821
EVOLUTION OF TARGETED THERAPIES FOR THYROID CARCINOMA.
Sherman SI
Trans Am Clin Climatol Assoc 2019;130:255-265. PMID: 31516190Free PMC Article
Percutaneous renal tumour biopsy.
Delahunt B, Samaratunga H, Martignoni G, Srigley JR, Evans AJ, Brunelli M
Histopathology 2014 Sep;65(3):295-308. doi: 10.1111/his.12495. PMID: 25041600
Hürthle cell carcinoma.
Yutan E, Clark OH
Curr Treat Options Oncol 2001 Aug;2(4):331-5. doi: 10.1007/s11864-001-0026-4. PMID: 12057113

Prognosis

Oncocytic Change in Thyroid Pathology.
Asa SL, Mete O
Front Endocrinol (Lausanne) 2021;12:678119. Epub 2021 May 3 doi: 10.3389/fendo.2021.678119. PMID: 34012422Free PMC Article
Thyroid oncocytic neoplasms.
Doghri R, Znaidi N, Blel A, Aloui R, Lahyeni R, Ben Salah M, Rammeh S
Tunis Med 2018 Mar;96(3):219-223. PMID: 30325491
Novel aspects in histopathology of the pituitary gland.
Tortosa F, Webb SM
Endocrinol Diabetes Nutr 2017 Mar;64(3):152-161. Epub 2017 Feb 23 doi: 10.1016/j.endinu.2016.10.004. PMID: 28440754
Intraductal Oncocytic Papillary Neoplasms of the Pancreas.
Kallen ME, Naini BV
Arch Pathol Lab Med 2016 Sep;140(9):992-6. doi: 10.5858/arpa.2014-0595-RS. PMID: 27575268
Follicular thyroid carcinoma.
Sobrinho-Simões M, Eloy C, Magalhães J, Lobo C, Amaro T
Mod Pathol 2011 Apr;24 Suppl 2:S10-8. doi: 10.1038/modpathol.2010.133. PMID: 21455197

Clinical prediction guides

Molecular Alterations and Comprehensive Clinical Management of Oncocytic Thyroid Carcinoma: A Review and Multidisciplinary 2023 Update.
Bischoff LA, Ganly I, Fugazzola L, Buczek E, Faquin WC, Haugen BR, McIver B, McMullen CP, Newbold K, Rocke DJ, Russell MD, Ryder M, Sadow PM, Sherman E, Shindo M, Shonka DC Jr, Singer MC, Stack BC Jr, Wirth LJ, Wong RJ, Randolph GW
JAMA Otolaryngol Head Neck Surg 2024 Mar 1;150(3):265-272. doi: 10.1001/jamaoto.2023.4323. PMID: 38206595
Oncocytic Change in Thyroid Pathology.
Asa SL, Mete O
Front Endocrinol (Lausanne) 2021;12:678119. Epub 2021 May 3 doi: 10.3389/fendo.2021.678119. PMID: 34012422Free PMC Article
Thyroid oncocytic neoplasms.
Doghri R, Znaidi N, Blel A, Aloui R, Lahyeni R, Ben Salah M, Rammeh S
Tunis Med 2018 Mar;96(3):219-223. PMID: 30325491
Follicular thyroid carcinoma.
Sobrinho-Simões M, Eloy C, Magalhães J, Lobo C, Amaro T
Mod Pathol 2011 Apr;24 Suppl 2:S10-8. doi: 10.1038/modpathol.2010.133. PMID: 21455197
Oncocytic adrenocortical carcinoma.
Ohtake H, Kawamura H, Matsuzaki M, Yokoyama E, Kitajima M, Onizuka S, Yamakawa M
Ann Diagn Pathol 2010 Jun;14(3):204-8. Epub 2009 Sep 8 doi: 10.1016/j.anndiagpath.2009.06.006. PMID: 20471567

Recent systematic reviews

CT radiomics for differentiating oncocytoma from renal cell carcinomas: Systematic review and meta-analysis.
Dehghani Firouzabadi F, Gopal N, Homayounieh F, Anari PY, Li X, Ball MW, Jones EC, Samimi S, Turkbey E, Malayeri AA
Clin Imaging 2023 Feb;94:9-17. Epub 2022 Nov 17 doi: 10.1016/j.clinimag.2022.11.007. PMID: 36459898Free PMC Article
A systematic review of sinonasal oncocytomas and oncocytic carcinomas: Diagnosis, management, and technical considerations.
Hodzic Z, Rowan NR, Kashiwazaki R, Willson TJ, Wang EW, Lee SE
Int Forum Allergy Rhinol 2017 May;7(5):514-524. Epub 2017 Jan 16 doi: 10.1002/alr.21902. PMID: 28092140
Understanding pathologic variants of renal cell carcinoma: distilling therapeutic opportunities from biologic complexity.
Shuch B, Amin A, Armstrong AJ, Eble JN, Ficarra V, Lopez-Beltran A, Martignoni G, Rini BI, Kutikov A
Eur Urol 2015 Jan;67(1):85-97. Epub 2014 May 21 doi: 10.1016/j.eururo.2014.04.029. PMID: 24857407
Gender differences in benign renal masses.
Mauermann J, de Martino M, Waldert M, Haitel A, Klingler HC, Remzi M, Klatte T
World J Urol 2013 Oct;31(5):1051-7. Epub 2013 Feb 16 doi: 10.1007/s00345-013-1032-4. PMID: 23417319
Adrenal oncocytic neoplasm: a systematic review.
Mearini L, Del Sordo R, Costantini E, Nunzi E, Porena M
Urol Int 2013;91(2):125-33. Epub 2012 Nov 8 doi: 10.1159/000345141. PMID: 23147196

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