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Tumor stage mycosis fungoides

MedGen UID:
698729
•Concept ID:
C1275465
•
Neoplastic Process
Synonym: Tumor stage cutaneous T-cell lymphoma
SNOMED CT: Tumor stage mycosis fungoides (404113004); Tumor stage cutaneous T-cell lymphoma (404113004)

Professional guidelines

PubMed

Treatment of cutaneous T-cell lymphomas (CTCL) with extracorporeal photochemotherapy--preliminary report.
Nagatani T, Matsuzaki T, Kim S, Baba N, Osawa J, Sugiyama A, Komatsu H, Ichiyama S, Takahashi Y, Miyamoto H
J Dermatol 1990 Dec;17(12):737-45. doi: 10.1111/j.1346-8138.1990.tb03022.x. PMID: 2086618

Recent clinical studies

Etiology

Low-Dose MST-16/VP-16 Combination Chemotherapy in 9 Patients with Tumor Stage Mycosis Fungoides.
Kato Y, Fukuhara Y, Nagatani T, Kanzaki A, Mae KI, Irisawa R, Harada K, Umebayashi Y, Tsuboi R
Dermatology 2022;238(5):961-966. Epub 2022 May 12 doi: 10.1159/000522631. PMID: 35551376
Tumor stage mycosis fungoides: a single-center study on clinicopathologic features, treatments, and patient outcome.
Patrawala SA, Broussard KC, Wang L, Zic JA
Dermatol Online J 2016 May 15;22(5) PMID: 27617516
Oligonucleotide array-CGH identifies genomic subgroups and prognostic markers for tumor stage mycosis fungoides.
Salgado R, Servitje O, Gallardo F, Vermeer MH, Ortiz-Romero PL, Karpova MB, Zipser MC, Muniesa C, García-Muret MP, Estrach T, Salido M, Sánchez-Schmidt J, Herrera M, Romagosa V, Suela J, Ferreira BI, Cigudosa JC, Barranco C, Serrano S, Dummer R, Tensen CP, Solé F, Pujol RM, Espinet B
J Invest Dermatol 2010 Apr;130(4):1126-35. Epub 2009 Sep 17 doi: 10.1038/jid.2009.306. PMID: 19759554
Low-dose methotrexate to treat mycosis fungoides: a retrospective study in 69 patients.
Zackheim HS, Kashani-Sabet M, McMillan A
J Am Acad Dermatol 2003 Nov;49(5):873-8. doi: 10.1016/s0190-9622(03)01591-3. PMID: 14576667
Estimates of nuclear volume in plaque and tumor-stage mycosis fungoides. A new prognostic indicator.
Brooks B, Sørensen FB, Thestrup-Pedersen K
Am J Dermatopathol 1994 Dec;16(6):599-606. doi: 10.1097/00000372-199412000-00005. PMID: 7864297

Diagnosis

Tumor stage mycosis fungoides: a single-center study on clinicopathologic features, treatments, and patient outcome.
Patrawala SA, Broussard KC, Wang L, Zic JA
Dermatol Online J 2016 May 15;22(5) PMID: 27617516
Tumor Stage Mycosis Fungoides in a Child.
Dulmage BO, Villaseñor-Park J, Ho J, Geskin LJ, Grandinetti LM
Pediatr Dermatol 2015 Jul-Aug;32(4):e156-8. Epub 2015 Apr 17 doi: 10.1111/pde.12570. PMID: 25892093
Case for diagnosis.
Pedrosa AF, Ferreira O, Barros AM, Nogueira A, Bettencourt H, Azevedo F
An Bras Dermatol 2013 Sep-Oct;88(5):824-5. doi: 10.1590/abd1806-4841.20132258. PMID: 24173195Free PMC Article
A meta-analysis of gene expression data identifies a molecular signature characteristic for tumor-stage mycosis fungoides.
van Kester MS, Borg MK, Zoutman WH, Out-Luiting JJ, Jansen PM, Dreef EJ, Vermeer MH, van Doorn R, Willemze R, Tensen CP
J Invest Dermatol 2012 Aug;132(8):2050-9. Epub 2012 Apr 19 doi: 10.1038/jid.2012.117. PMID: 22513784
Mycosis fungoides: classic disease and variant presentations.
Howard MS, Smoller BR
Semin Cutan Med Surg 2000 Jun;19(2):91-9. doi: 10.1016/s1085-5629(00)80005-x. PMID: 10892710

Therapy

Low-Dose MST-16/VP-16 Combination Chemotherapy in 9 Patients with Tumor Stage Mycosis Fungoides.
Kato Y, Fukuhara Y, Nagatani T, Kanzaki A, Mae KI, Irisawa R, Harada K, Umebayashi Y, Tsuboi R
Dermatology 2022;238(5):961-966. Epub 2022 May 12 doi: 10.1159/000522631. PMID: 35551376
Tumor-stage mycosis fungoides in palmoplantar localization with large-cell transformation and partial CD30 expression shows complete response to brentuximab vedotin.
Pham AK, Carter JB, Ratcliffe NR, Fuld AD, Lansigan F, Burnside NJ, Guill MA 3rd, Zug KA, Jarvis LA, LeBlanc RE
J Cutan Pathol 2018 Jun;45(6):458-462. Epub 2018 Apr 6 doi: 10.1111/cup.13140. PMID: 29512830
Tumor stage mycosis fungoides: a single-center study on clinicopathologic features, treatments, and patient outcome.
Patrawala SA, Broussard KC, Wang L, Zic JA
Dermatol Online J 2016 May 15;22(5) PMID: 27617516
Low-dose gemcitabine efficacious in three patients with tumor-stage mycosis fungoides.
Buhl T, Bertsch HP, Kaune KM, Mitteldorf C, Schön MP, Kretschmer L
Clin Lymphoma Myeloma 2009 Oct;9(5):E21-4. doi: 10.3816/CLM.2009.n.079. PMID: 19858049
Combined modality therapy for tumor stage mycosis fungoides: results of a 10-year follow-up.
Hallahan DE, Griem ML, Griem SF, Medenica M, Soltani K, Lorincz AL, Baron JM
J Clin Oncol 1988 Jul;6(7):1177-83. doi: 10.1200/JCO.1988.6.7.1177. PMID: 3392562

Prognosis

Oncogenomic analysis identifies novel biomarkers for tumor stage mycosis fungoides.
Dong Z, Zhu X, Li Y, Gan L, Chen H, Zhang W, Sun J
Medicine (Baltimore) 2018 May;97(21):e10871. doi: 10.1097/MD.0000000000010871. PMID: 29794791Free PMC Article
Tumor stage mycosis fungoides: a single-center study on clinicopathologic features, treatments, and patient outcome.
Patrawala SA, Broussard KC, Wang L, Zic JA
Dermatol Online J 2016 May 15;22(5) PMID: 27617516
Leser-Trélat Sign in Tumor-Stage Mycosis Fungoides.
Rowe B, Shevchenko A, Yosipovitch G
Dermatol Online J 2016 Apr 18;22(4) PMID: 27617461
Oligonucleotide array-CGH identifies genomic subgroups and prognostic markers for tumor stage mycosis fungoides.
Salgado R, Servitje O, Gallardo F, Vermeer MH, Ortiz-Romero PL, Karpova MB, Zipser MC, Muniesa C, García-Muret MP, Estrach T, Salido M, Sánchez-Schmidt J, Herrera M, Romagosa V, Suela J, Ferreira BI, Cigudosa JC, Barranco C, Serrano S, Dummer R, Tensen CP, Solé F, Pujol RM, Espinet B
J Invest Dermatol 2010 Apr;130(4):1126-35. Epub 2009 Sep 17 doi: 10.1038/jid.2009.306. PMID: 19759554
Mycosis fungoides: classic disease and variant presentations.
Howard MS, Smoller BR
Semin Cutan Med Surg 2000 Jun;19(2):91-9. doi: 10.1016/s1085-5629(00)80005-x. PMID: 10892710

Clinical prediction guides

Successful treatment of tumor stage mycosis fungoides with total skin helical tomotherapy.
Yonekura K, Ichiki M, Takeda K, Uchiyama N, Nishida H, Dokiya T
J Dermatol 2022 Feb;49(2):289-293. Epub 2021 Nov 21 doi: 10.1111/1346-8138.16246. PMID: 34806213
Low-dose gemcitabine efficacious in three patients with tumor-stage mycosis fungoides.
Buhl T, Bertsch HP, Kaune KM, Mitteldorf C, Schön MP, Kretschmer L
Clin Lymphoma Myeloma 2009 Oct;9(5):E21-4. doi: 10.3816/CLM.2009.n.079. PMID: 19858049
Low-dose methotrexate to treat mycosis fungoides: a retrospective study in 69 patients.
Zackheim HS, Kashani-Sabet M, McMillan A
J Am Acad Dermatol 2003 Nov;49(5):873-8. doi: 10.1016/s0190-9622(03)01591-3. PMID: 14576667
Long-term remission after allogeneic hematopoietic stem cell transplantation for refractory cutaneous T-cell lymphoma.
Guitart J, Wickless SC, Oyama Y, Kuzel TM, Rosen ST, Traynor A, Burt R
Arch Dermatol 2002 Oct;138(10):1359-65. doi: 10.1001/archderm.138.10.1359. PMID: 12374543
Estimates of nuclear volume in plaque and tumor-stage mycosis fungoides. A new prognostic indicator.
Brooks B, Sørensen FB, Thestrup-Pedersen K
Am J Dermatopathol 1994 Dec;16(6):599-606. doi: 10.1097/00000372-199412000-00005. PMID: 7864297

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