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Primary Graft Dysfunction

MedGen UID:
215293
Concept ID:
C0948031
Pathologic Function
Synonyms: Dysfunction, Primary Graft; Graft Dysfunction, Primary

Definition

A form of ischemia-reperfusion injury occurring in the early period following transplantation. Significant pathophysiological changes in MITOCHONDRIA are the main cause of the dysfunction. It is most often seen in the transplanted lung, liver, or kidney and can lead to GRAFT REJECTION. [from MeSH]

Professional guidelines

PubMed

Natalini JG, Diamond JM
Semin Respir Crit Care Med 2021 Jun;42(3):368-379. Epub 2021 May 24 doi: 10.1055/s-0041-1728794. PMID: 34030200
Criner RN, Clausen E, Cantu E
Curr Opin Organ Transplant 2021 Jun 1;26(3):321-327. doi: 10.1097/MOT.0000000000000876. PMID: 33938469
Suzuki Y, Cantu E, Christie JD
Semin Respir Crit Care Med 2013 Jun;34(3):305-319. Epub 2013 Jul 2 doi: 10.1055/s-0033-1348474. PMID: 23821506Free PMC Article

Recent clinical studies

Etiology

Natalini JG, Diamond JM
Semin Respir Crit Care Med 2021 Jun;42(3):368-379. Epub 2021 May 24 doi: 10.1055/s-0041-1728794. PMID: 34030200
Criner RN, Clausen E, Cantu E
Curr Opin Organ Transplant 2021 Jun 1;26(3):321-327. doi: 10.1097/MOT.0000000000000876. PMID: 33938469
Kobashigawa J, Zuckermann A, Macdonald P, Leprince P, Esmailian F, Luu M, Mancini D, Patel J, Razi R, Reichenspurner H, Russell S, Segovia J, Smedira N, Stehlik J, Wagner F; Consensus Conference participants
J Heart Lung Transplant 2014 Apr;33(4):327-40. Epub 2014 Mar 5 doi: 10.1016/j.healun.2014.02.027. PMID: 24661451
Suzuki Y, Cantu E, Christie JD
Semin Respir Crit Care Med 2013 Jun;34(3):305-319. Epub 2013 Jul 2 doi: 10.1055/s-0033-1348474. PMID: 23821506Free PMC Article
Lee JC, Christie JD
Clin Chest Med 2011 Jun;32(2):279-93. doi: 10.1016/j.ccm.2011.02.007. PMID: 21511090

Diagnosis

Assadiasl S, Nicknam MH
Lung 2022 Dec;200(6):793-806. Epub 2022 Nov 8 doi: 10.1007/s00408-022-00588-1. PMID: 36348053
Swaminathan AC, Todd JL, Palmer SM
Annu Rev Med 2021 Jan 27;72:135-149. Epub 2020 Oct 28 doi: 10.1146/annurev-med-080119-103200. PMID: 33113336
Mangini S, Alves BR, Silvestre OM, Pires PV, Pires LJ, Curiati MN, Bacal F
Einstein (Sao Paulo) 2015 Apr-Jun;13(2):310-8. doi: 10.1590/S1679-45082015RW3154. PMID: 26154552Free PMC Article
Kobashigawa J, Zuckermann A, Macdonald P, Leprince P, Esmailian F, Luu M, Mancini D, Patel J, Razi R, Reichenspurner H, Russell S, Segovia J, Smedira N, Stehlik J, Wagner F; Consensus Conference participants
J Heart Lung Transplant 2014 Apr;33(4):327-40. Epub 2014 Mar 5 doi: 10.1016/j.healun.2014.02.027. PMID: 24661451
Lee JC, Christie JD
Clin Chest Med 2011 Jun;32(2):279-93. doi: 10.1016/j.ccm.2011.02.007. PMID: 21511090

Therapy

Assadiasl S, Nicknam MH
Lung 2022 Dec;200(6):793-806. Epub 2022 Nov 8 doi: 10.1007/s00408-022-00588-1. PMID: 36348053
Venado A, Kukreja J, Greenland JR
Thorac Surg Clin 2022 May;32(2):231-242. doi: 10.1016/j.thorsurg.2021.11.004. PMID: 35512941
Natalini JG, Diamond JM
Semin Respir Crit Care Med 2021 Jun;42(3):368-379. Epub 2021 May 24 doi: 10.1055/s-0041-1728794. PMID: 34030200
Criner RN, Clausen E, Cantu E
Curr Opin Organ Transplant 2021 Jun 1;26(3):321-327. doi: 10.1097/MOT.0000000000000876. PMID: 33938469
Kok B, Dong V, Karvellas CJ
Crit Care Clin 2019 Jan;35(1):117-133. Epub 2018 Oct 25 doi: 10.1016/j.ccc.2018.08.002. PMID: 30447775

Prognosis

Swaminathan AC, Todd JL, Palmer SM
Annu Rev Med 2021 Jan 27;72:135-149. Epub 2020 Oct 28 doi: 10.1146/annurev-med-080119-103200. PMID: 33113336
Potena L, Zuckermann A, Barberini F, Aliabadi-Zuckermann A
Curr Cardiol Rep 2018 Jul 10;20(9):73. doi: 10.1007/s11886-018-1018-3. PMID: 29992503
Afonso Júnior JE, Werebe Ede C, Carraro RM, Teixeira RH, Fernandes LM, Abdalla LG, Samano MN, Pêgo-Fernandes PM
Einstein (Sao Paulo) 2015 Apr-Jun;13(2):297-304. doi: 10.1590/S1679-45082015RW3156. PMID: 26154550Free PMC Article
Kotloff RM, Thabut G
Am J Respir Crit Care Med 2011 Jul 15;184(2):159-71. Epub 2011 Mar 31 doi: 10.1164/rccm.201101-0134CI. PMID: 21471083
Lee JC, Christie JD
Proc Am Thorac Soc 2009 Jan 15;6(1):39-46. doi: 10.1513/pats.200808-082GO. PMID: 19131529

Clinical prediction guides

Brahmbhatt DH, Blitzer D, Billia F, Copeland H
Curr Opin Organ Transplant 2023 Oct 1;28(5):376-383. Epub 2023 Aug 9 doi: 10.1097/MOT.0000000000001091. PMID: 37678172
Hunt ML, Cantu E
Curr Opin Organ Transplant 2023 Jun 1;28(3):180-186. Epub 2023 Apr 13 doi: 10.1097/MOT.0000000000001065. PMID: 37053083Free PMC Article
Shah RJ, Diamond JM
Semin Respir Crit Care Med 2018 Apr;39(2):148-154. Epub 2018 Mar 28 doi: 10.1055/s-0037-1615797. PMID: 29590671
Shaver CM, Ware LB
Expert Rev Respir Med 2017 Feb;11(2):119-128. Epub 2017 Jan 20 doi: 10.1080/17476348.2017.1280398. PMID: 28074663Free PMC Article
Chen XB, Xu MQ
Hepatobiliary Pancreat Dis Int 2014 Apr;13(2):125-37. doi: 10.1016/s1499-3872(14)60023-0. PMID: 24686540

Recent systematic reviews

Song W, Xiong X, Ge W, Zhu H
Proteomics Clin Appl 2022 Jul;16(4):e2100038. Epub 2022 Apr 14 doi: 10.1002/prca.202100038. PMID: 35344271
Ali A, Pettenuzzo T, Ramadan K, Farrell A, Di Nardo M, Liu M, Keshavjee S, Fan E, Cypel M, Del Sorbo L
Transplant Rev (Orlando) 2021 Dec;35(4):100637. Epub 2021 Jun 30 doi: 10.1016/j.trre.2021.100637. PMID: 34224988
Klapper JA, Hicks AC, Ledbetter L, Poisson J, Hartwig MG, Hashmi N, Welsby I, Bottiger BA
Clin Transplant 2021 Oct;35(10):e14404. Epub 2021 Jul 8 doi: 10.1111/ctr.14404. PMID: 34176163
Phan K, Luc JGY, Xu J, Maltais S, Stulak JM, Yan TD, Tchantchaleishvili V
ASAIO J 2017 Nov/Dec;63(6):695-703. doi: 10.1097/MAT.0000000000000599. PMID: 28906273
Upala S, Panichsillapakit T, Wijarnpreecha K, Jaruvongvanich V, Sanguankeo A
Transpl Int 2016 Mar;29(3):285-96. Epub 2015 Dec 29 doi: 10.1111/tri.12721. PMID: 26613209

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