U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Progressive spastic paraparesis

MedGen UID:
488935
Concept ID:
C0747251
Sign or Symptom
HPO: HP:0007199

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Progressive spastic paraparesis

Professional guidelines

PubMed

Rashad S, Abdel-Bary M, Aziz W, Hassan T
Clin Neurol Neurosurg 2014 Oct;125:81-6. Epub 2014 Jul 27 doi: 10.1016/j.clineuro.2014.07.028. PMID: 25108697
Fink JK
Semin Neurol 2001 Jun;21(2):199-207. doi: 10.1055/s-2001-15265. PMID: 11442328
Younger DS
Semin Neurol 1993 Dec;13(4):319-21. doi: 10.1055/s-2008-1041141. PMID: 8146480

Recent clinical studies

Etiology

Alkhalifa A, Chen S, Hasiloglu ZI, Filosto M, Cali E, Houlden H, Sgobbi de Souza P, Alavi A, Goizet C, Stevanin G, Taithe F, Nicita F, Vasco G, Tozza S, Cocozza S, Carboni N, Figus A, Wu J, Basak AN, Brais B, Rouleau G, La Piana R
J Neurol 2023 Dec;270(12):5784-5792. Epub 2023 Aug 14 doi: 10.1007/s00415-023-11918-5. PMID: 37578488
Kessler C, Ruschil C, Abdelhak A, Wilke C, Maleska A, Kuhle J, Krumbholz M, Kowarik MC, Schüle R
Int J Mol Sci 2022 Nov 3;23(21) doi: 10.3390/ijms232113466. PMID: 36362248Free PMC Article
Takenouchi N, Tanaka M, Sato T, Yao J, Fujisawa JI, Izumo S, Kubota R, Matsuura E
J Neurovirol 2020 Jun;26(3):404-414. Epub 2020 Apr 13 doi: 10.1007/s13365-020-00838-z. PMID: 32285300
Kevelam SH, Neeleman RA, Waisfisz Q, Friesema EC, Langendonk JG, van der Knaap MS
Neurology 2016 Sep 20;87(12):1258-65. Epub 2016 Aug 24 doi: 10.1212/WNL.0000000000003129. PMID: 27558376
Contino G, Novelli G
Expert Opin Pharmacother 2006 Oct;7(14):1849-56. doi: 10.1517/14656566.7.14.1849. PMID: 17020412

Diagnosis

Alkhalifa A, Chen S, Hasiloglu ZI, Filosto M, Cali E, Houlden H, Sgobbi de Souza P, Alavi A, Goizet C, Stevanin G, Taithe F, Nicita F, Vasco G, Tozza S, Cocozza S, Carboni N, Figus A, Wu J, Basak AN, Brais B, Rouleau G, La Piana R
J Neurol 2023 Dec;270(12):5784-5792. Epub 2023 Aug 14 doi: 10.1007/s00415-023-11918-5. PMID: 37578488
Mitsutake A, Matsukawa T, Iwata A, Ishiura H, Mitsui J, Mori H, Toya T, Honda A, Kurokawa M, Sakai N, Tsuji S, Toda T
Brain Dev 2023 Aug;45(7):408-412. Epub 2023 Apr 18 doi: 10.1016/j.braindev.2023.04.001. PMID: 37080866
Zhovtis Ryerson L, Herbert J, Howard J, Kister I
J Neurol Sci 2014 Nov 15;346(1-2):43-50. Epub 2014 Sep 19 doi: 10.1016/j.jns.2014.09.015. PMID: 25263600
Misra S, Ramesh R, Ramu ChS, Srirangalaxmi G, Radhakrishn H, Vajresware
J Assoc Physicians India 2012 Jul;60:58-61. PMID: 23405547
Spencer PS, Schaumburg HH
Neurobehav Toxicol Teratol 1983 Nov-Dec;5(6):625-9. PMID: 6422318

Therapy

Kumar NH, Mounika KJ, Sundarachary NV
Neurol India 2023 Mar-Apr;71(2):326-328. doi: 10.4103/0028-3886.375409. PMID: 37148062
Nozuma S, Kubota R, Jacobson S
J Neurovirol 2020 Oct;26(5):652-663. Epub 2020 Jul 23 doi: 10.1007/s13365-020-00881-w. PMID: 32705480Free PMC Article
Catarino CB, Vollmar C, Küpper C, Seelos K, Gallenmüller C, Bartkiewicz J, Biskup S, Hörtnagel K, Klopstock T
J Neurol 2018 Feb;265(2):388-393. Epub 2017 Dec 19 doi: 10.1007/s00415-017-8711-9. PMID: 29260356
Misra S, Ramesh R, Ramu ChS, Srirangalaxmi G, Radhakrishn H, Vajresware
J Assoc Physicians India 2012 Jul;60:58-61. PMID: 23405547
Contino G, Novelli G
Expert Opin Pharmacother 2006 Oct;7(14):1849-56. doi: 10.1517/14656566.7.14.1849. PMID: 17020412

Prognosis

Mitsutake A, Matsukawa T, Iwata A, Ishiura H, Mitsui J, Mori H, Toya T, Honda A, Kurokawa M, Sakai N, Tsuji S, Toda T
Brain Dev 2023 Aug;45(7):408-412. Epub 2023 Apr 18 doi: 10.1016/j.braindev.2023.04.001. PMID: 37080866
Ruaud L, Rice GI, Cabrol C, Piard J, Rodero M, van Eyk L, Boucher-Brischoux E, de Noordhout AM, Maré R, Scalais E, Pauly F, Debray FG, Dobyns W, Uggenti C, Park JW, Hur S, Livingston JH, Crow YJ, Van Maldergem L
Hum Mutat 2018 Aug;39(8):1076-1080. Epub 2018 Jun 4 doi: 10.1002/humu.23554. PMID: 29782060Free PMC Article
Misra S, Ramesh R, Ramu ChS, Srirangalaxmi G, Radhakrishn H, Vajresware
J Assoc Physicians India 2012 Jul;60:58-61. PMID: 23405547
Contino G, Novelli G
Expert Opin Pharmacother 2006 Oct;7(14):1849-56. doi: 10.1517/14656566.7.14.1849. PMID: 17020412
Achiron A, Pinhas-Hamiel O, Doll L, Djaldetti R, Chen A, Ziv I, Avni A, Frankel G, Melamed E, Shohat B
Ann Neurol 1993 Nov;34(5):670-5. doi: 10.1002/ana.410340508. PMID: 8239561

Clinical prediction guides

Alkhalifa A, Chen S, Hasiloglu ZI, Filosto M, Cali E, Houlden H, Sgobbi de Souza P, Alavi A, Goizet C, Stevanin G, Taithe F, Nicita F, Vasco G, Tozza S, Cocozza S, Carboni N, Figus A, Wu J, Basak AN, Brais B, Rouleau G, La Piana R
J Neurol 2023 Dec;270(12):5784-5792. Epub 2023 Aug 14 doi: 10.1007/s00415-023-11918-5. PMID: 37578488
Mitsutake A, Matsukawa T, Iwata A, Ishiura H, Mitsui J, Mori H, Toya T, Honda A, Kurokawa M, Sakai N, Tsuji S, Toda T
Brain Dev 2023 Aug;45(7):408-412. Epub 2023 Apr 18 doi: 10.1016/j.braindev.2023.04.001. PMID: 37080866
Takenouchi N, Tanaka M, Sato T, Yao J, Fujisawa JI, Izumo S, Kubota R, Matsuura E
J Neurovirol 2020 Jun;26(3):404-414. Epub 2020 Apr 13 doi: 10.1007/s13365-020-00838-z. PMID: 32285300
Contino G, Novelli G
Expert Opin Pharmacother 2006 Oct;7(14):1849-56. doi: 10.1517/14656566.7.14.1849. PMID: 17020412
Halperin JJ
Scand J Infect Dis Suppl 1991;77:74-80. PMID: 1658921

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...