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Decreased mean corpuscular hemoglobin concentration

MedGen UID:
605648
•Concept ID:
C0427437
•
Finding
Synonym: Decreased mean corpuscular hemoglobin
SNOMED CT: MCH - low (165439008); Mean corpuscular hemoglobin (MCH) - low (165439008); Mean corpuscular hemoglobin low (165439008); Mean corpuscular hemoglobin below reference range (165439008)
 
HPO: HP:0025547

Definition

A reduction from the normal range of the average amount of hemoglobin per red blood cell (27 to 31 picograms/cell). A reduced mean corpuscular hemoglobin (MCH) may indicate a hypochromic anemia, but the MCH may be normal if both the total hemoglobin and the red blood cell count are reduced. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDecreased mean corpuscular hemoglobin concentration

Conditions with this feature

Dominant beta-thalassemia
MedGen UID:
347036
•Concept ID:
C1858990
•
Disease or Syndrome
Dominantly inherited inclusion body beta-thalassemia is characterized by the presence of inclusion bodies in red blood cell precursors, moderately severe anemia, jaundice, and splenomegaly (summary by Ropero et al., 2005).
See: Condition Record
Dominant beta-thalassemia

Professional guidelines

PubMed

Treatment with NS3623, a novel Cl-conductance blocker, ameliorates erythrocyte dehydration in transgenic SAD mice: a possible new therapeutic approach for sickle cell disease.
Bennekou P, de Franceschi L, Pedersen O, Lian L, Asakura T, Evans G, Brugnara C, Christophersen P
Blood 2001 Mar 1;97(5):1451-7. doi: 10.1182/blood.v97.5.1451. PMID: 11222393

Recent clinical studies

Etiology

Concurrent sickle-cell anemia and alpha-thalassemia: effect on severity of anemia.
Embury SH, Dozy AM, Miller J, Davis JR Jr, Kleman KM, Preisler H, Vichinsky E, Lande WN, Lubin BH, Kan YW, Mentzer WC
N Engl J Med 1982 Feb 4;306(5):270-4. doi: 10.1056/NEJM198202043060504. PMID: 6172710

Diagnosis

Concurrent sickle-cell anemia and alpha-thalassemia: effect on severity of anemia.
Embury SH, Dozy AM, Miller J, Davis JR Jr, Kleman KM, Preisler H, Vichinsky E, Lande WN, Lubin BH, Kan YW, Mentzer WC
N Engl J Med 1982 Feb 4;306(5):270-4. doi: 10.1056/NEJM198202043060504. PMID: 6172710

Clinical prediction guides

Mechanism of faster NO scavenging by older stored red blood cells.
Liu C, Liu X, Janes J, Stapley R, Patel RP, Gladwin MT, Kim-Shapiro DB
Redox Biol 2014;2:211-9. Epub 2014 Jan 10 doi: 10.1016/j.redox.2013.12.014. PMID: 24494195Free PMC Article

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