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Opsoclonus-myoclonus syndrome

MedGen UID:
97955
Concept ID:
C0393626
Disease or Syndrome
Synonyms: Dancing eyes-dancing feet syndrome; Infantile polymyoclonus; Kinsbourne syndrome
SNOMED CT: Opsoclonus-myoclonus syndrome (230350000)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0015247
Orphanet: ORPHA1183

Definition

Opsoclonus myoclonus syndrome (OMS) is a rare neuroinflammatory disease of paraneoplastic, parainfectious or idiopathic origin, characterized by opsoclonus, myoclonus, ataxia, and behavioral and sleep disorders. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Opsoclonus-myoclonus syndrome

Professional guidelines

PubMed

Gupta A, Kundal R, Pandey M
J Coll Physicians Surg Pak 2022 Aug;32(8):1086-1088. doi: 10.29271/jcpsp.2022.08.1086. PMID: 35932142
Mitoma H, Manto M, Hampe CS
Curr Neuropharmacol 2019;17(1):33-58. doi: 10.2174/1570159X16666180917105033. PMID: 30221603Free PMC Article
Grativvol RS, Cavalcante WCP, Castro LHM, Nitrini R, Simabukuro MM
Curr Oncol Rep 2018 Nov 10;20(11):92. doi: 10.1007/s11912-018-0721-y. PMID: 30415318

Recent clinical studies

Etiology

Meira AT, de Moraes MPM, Ferreira MG, Franklin GL, Rezende Filho FM, Teive HAG, Barsottini OGP, Pedroso JL
Parkinsonism Relat Disord 2023 Dec;117:105861. Epub 2023 Sep 20 doi: 10.1016/j.parkreldis.2023.105861. PMID: 37748994
Kang L, Wan C
J Neurol 2022 Oct;269(10):5272-5282. Epub 2022 Jul 2 doi: 10.1007/s00415-022-11247-z. PMID: 35779086
Rossor T, Yeh EA, Khakoo Y, Angelini P, Hemingway C, Irani SR, Schleiermacher G, Santosh P, Lotze T, Dale RC, Deiva K, Hero B, Klein A, de Alarcon P, Gorman MP, Mitchell WG, Lim M; OMS Study Group
Neurol Neuroimmunol Neuroinflamm 2022 May;9(3) Epub 2022 Mar 8 doi: 10.1212/NXI.0000000000001153. PMID: 35260471Free PMC Article
Joubert B, Rostásy K, Honnorat J
Handb Clin Neurol 2018;155:313-332. doi: 10.1016/B978-0-444-64189-2.00021-4. PMID: 29891069
Bussat A, Langner-Lemercier S, Salmon A, Mouriaux F
J Fr Ophtalmol 2018 May;41(5):e181-e185. Epub 2018 May 18 doi: 10.1016/j.jfo.2018.03.002. PMID: 29784239

Diagnosis

Rossor T, Yeh EA, Khakoo Y, Angelini P, Hemingway C, Irani SR, Schleiermacher G, Santosh P, Lotze T, Dale RC, Deiva K, Hero B, Klein A, de Alarcon P, Gorman MP, Mitchell WG, Lim M; OMS Study Group
Neurol Neuroimmunol Neuroinflamm 2022 May;9(3) Epub 2022 Mar 8 doi: 10.1212/NXI.0000000000001153. PMID: 35260471Free PMC Article
Bhatia P, Heim J, Cornejo P, Kane L, Santiago J, Kruer MC
J Neurol 2022 Feb;269(2):750-757. Epub 2021 Mar 29 doi: 10.1007/s00415-021-10536-3. PMID: 33779841
Oh SY, Kim JS, Dieterich M
J Neurol 2019 Jun;266(6):1541-1548. Epub 2018 Nov 27 doi: 10.1007/s00415-018-9138-7. PMID: 30483882
Mitoma H, Manto M, Hampe CS
Curr Neuropharmacol 2019;17(1):33-58. doi: 10.2174/1570159X16666180917105033. PMID: 30221603Free PMC Article
Pike M
Handb Clin Neurol 2013;112:1209-11. doi: 10.1016/B978-0-444-52910-7.00042-8. PMID: 23622330

Therapy

Yıldırım M, Öncel İ, Bektaş Ö, Tanalı G, Şahin S, Kutluk T, Teber S, Anlar B
Eur J Paediatr Neurol 2022 Nov;41:19-26. Epub 2022 Sep 20 doi: 10.1016/j.ejpn.2022.09.002. PMID: 36155293
Basu S, Chakravarty A
Curr Neurol Neurosci Rep 2022 Aug;22(8):491-498. Epub 2022 Jun 21 doi: 10.1007/s11910-022-01215-5. PMID: 35727462
Nelson JL, Blume GM, Bansal SK, Kaufman JR, Woods FR, Zhang X, Kattah JC
J Neuroophthalmol 2022 Jun 1;42(2):251-255. Epub 2021 Dec 30 doi: 10.1097/WNO.0000000000001498. PMID: 34974489
Pranzatelli MR, Tate ED
Brain Dev 2016 May;38(5):439-48. Epub 2016 Jan 16 doi: 10.1016/j.braindev.2015.11.007. PMID: 26786246
Pike M
Handb Clin Neurol 2013;112:1209-11. doi: 10.1016/B978-0-444-52910-7.00042-8. PMID: 23622330

Prognosis

Adamaszek M, Langner S, Mehrholz J, Heiinrich A
Cerebellum 2024 Jun;23(3):1245-1248. Epub 2023 Oct 9 doi: 10.1007/s12311-023-01610-9. PMID: 37814146
Rossor T, Yeh EA, Khakoo Y, Angelini P, Hemingway C, Irani SR, Schleiermacher G, Santosh P, Lotze T, Dale RC, Deiva K, Hero B, Klein A, de Alarcon P, Gorman MP, Mitchell WG, Lim M; OMS Study Group
Neurol Neuroimmunol Neuroinflamm 2022 May;9(3) Epub 2022 Mar 8 doi: 10.1212/NXI.0000000000001153. PMID: 35260471Free PMC Article
Mitoma H, Manto M, Hampe CS
Curr Neuropharmacol 2019;17(1):33-58. doi: 10.2174/1570159X16666180917105033. PMID: 30221603Free PMC Article
Blaes F, Dharmalingam B
Expert Rev Neurother 2016 Jun;16(6):641-8. Epub 2016 Apr 27 doi: 10.1080/14737175.2016.1176914. PMID: 27095464
Pike M
Handb Clin Neurol 2013;112:1209-11. doi: 10.1016/B978-0-444-52910-7.00042-8. PMID: 23622330

Clinical prediction guides

Mendoza MA, Hass RM, Vaillant J, Johnson DR, Theel ES, Toledano M, Abu Saleh O
Clin Infect Dis 2024 Jan 25;78(1):80-89. doi: 10.1093/cid/ciad454. PMID: 37540989Free PMC Article
Rosenberg MI, Greenstein E, Buchkovich M, Peres A, Santoni-Rugiu E, Yang L, Mikl M, Vaksman Z, Gibbs DL, Reshef D, Salovin A, Irwin MS, Naranjo A, Ulitsky I, de Alarcon PA, Matthay KK, Weigman V, Yaari G, Panzer JA, Friedman N, Maris JM
Cell Rep 2023 Aug 29;42(8):112879. Epub 2023 Aug 2 doi: 10.1016/j.celrep.2023.112879. PMID: 37537844Free PMC Article
Baizabal-Carvallo JF, Jankovic J
J Neurol Sci 2018 Feb 15;385:175-184. Epub 2017 Dec 30 doi: 10.1016/j.jns.2017.12.035. PMID: 29406902
Blaes F, Tschernatsch M
Expert Rev Neurother 2010 Oct;10(10):1559-68. doi: 10.1586/ern.10.134. PMID: 20925471
Borg M
Neurophysiol Clin 2006 Sep-Dec;36(5-6):309-18. Epub 2007 Jan 17 doi: 10.1016/j.neucli.2006.12.006. PMID: 17336775

Recent systematic reviews

Cannilla H, Messe M, Girardin F, Borruat FX, Bally JF
Tremor Other Hyperkinet Mov (N Y) 2024;14:23. Epub 2024 May 8 doi: 10.5334/tohm.832. PMID: 38737300Free PMC Article
Allahyari F, Molaee H, Hosseini Nejad J
Z Naturforsch C J Biosci 2023 Jan 27;78(1-2):1-8. Epub 2022 Sep 12 doi: 10.1515/znc-2022-0092. PMID: 36087300
Gadian J, Kirk E, Holliday K, Lim M, Absoud M
Dev Med Child Neurol 2017 Feb;59(2):136-144. Epub 2016 Nov 30 doi: 10.1111/dmcn.13349. PMID: 27900773
Sweeney M, Sweney M, Soldán MM, Clardy SL
Pediatr Neurol 2016 Dec;65:86-89. Epub 2016 Sep 2 doi: 10.1016/j.pediatrneurol.2016.08.024. PMID: 27707529
Ben-Pazi H, Jaworowski S, Shalev RS
Dev Med Child Neurol 2011 Dec;53(12):1077-84. Epub 2011 Sep 27 doi: 10.1111/j.1469-8749.2011.04134.x. PMID: 21950517

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