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Acquired factor VIII deficiency disease

MedGen UID:
124426
•Concept ID:
C0272325
•
Disease or Syndrome
Synonyms: Factor 8 deficiency, acquired; Factor VIII deficiency, acquired
SNOMED CT: Acquired factor VIII deficiency (14230004); Acquired factor VIII deficiency disease (14230004)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0035735
Orphanet: ORPHA599480

Definition

An acquired coagulation disorder characterized by the partial or complete absence of factor VIII activity in the blood. [from NCI]

Professional guidelines

PubMed

Acquired hemophilia A: Updated review of evidence and treatment guidance.
Kruse-Jarres R, Kempton CL, Baudo F, Collins PW, Knoebl P, Leissinger CA, Tiede A, Kessler CM
Am J Hematol 2017 Jul;92(7):695-705. Epub 2017 Jun 5 doi: 10.1002/ajh.24777. PMID: 28470674
Acquired haemophilia: Epidemiology, clinical presentation, diagnosis and treatment.
Mingot-Castellano ME, Núñez R, Rodríguez-Martorell FJ
Med Clin (Barc) 2017 Apr 7;148(7):314-322. Epub 2017 Jan 22 doi: 10.1016/j.medcli.2016.11.030. PMID: 28118963
Treatment of von Willebrand Disease.
Curnow J, Pasalic L, Favaloro EJ
Semin Thromb Hemost 2016 Mar;42(2):133-46. Epub 2016 Feb 2 doi: 10.1055/s-0035-1569070. PMID: 26838696

Recent clinical studies

Etiology

A prospective, multicenter, open-label phase III study of emicizumab prophylaxis in patients with acquired hemophilia A.
Shima M, Amano K, Ogawa Y, Yoneyama K, Ozaki R, Kobayashi R, Sakaida E, Saito M, Okamura T, Ito T, Hattori N, Higasa S, Suzuki N, Seki Y, Nogami K
J Thromb Haemost 2023 Mar;21(3):534-545. Epub 2022 Dec 22 doi: 10.1016/j.jtha.2022.10.004. PMID: 36696195
Acquired hemophilia.
García-Chávez J, Majluf-Cruz A
Gac Med Mex 2020;156(1):67-77. doi: 10.24875/GMM.19005469. PMID: 32026881
Acquired hemophilia A: Updated review of evidence and treatment guidance.
Kruse-Jarres R, Kempton CL, Baudo F, Collins PW, Knoebl P, Leissinger CA, Tiede A, Kessler CM
Am J Hematol 2017 Jul;92(7):695-705. Epub 2017 Jun 5 doi: 10.1002/ajh.24777. PMID: 28470674
Demographic and clinical data in acquired hemophilia A: results from the European Acquired Haemophilia Registry (EACH2).
Knoebl P, Marco P, Baudo F, Collins P, Huth-Kühne A, Nemes L, Pellegrini F, Tengborn L, Lévesque H; EACH2 Registry Contributors
J Thromb Haemost 2012 Apr;10(4):622-31. doi: 10.1111/j.1538-7836.2012.04654.x. PMID: 22321904
Acquired inhibitors.
Cohen AJ, Kessler CM
Baillieres Clin Haematol 1996 Jun;9(2):331-54. doi: 10.1016/s0950-3536(96)80067-9. PMID: 8800509

Diagnosis

Acquired Hemophilia A.
Pai M
Hematol Oncol Clin North Am 2021 Dec;35(6):1131-1142. Epub 2021 Sep 15 doi: 10.1016/j.hoc.2021.07.007. PMID: 34535289
Acquired hemophilia.
García-Chávez J, Majluf-Cruz A
Gac Med Mex 2020;156(1):67-77. doi: 10.24875/GMM.19005469. PMID: 32026881
Acquired hemophilia A: Updated review of evidence and treatment guidance.
Kruse-Jarres R, Kempton CL, Baudo F, Collins PW, Knoebl P, Leissinger CA, Tiede A, Kessler CM
Am J Hematol 2017 Jul;92(7):695-705. Epub 2017 Jun 5 doi: 10.1002/ajh.24777. PMID: 28470674
Acquired haemophilia: Epidemiology, clinical presentation, diagnosis and treatment.
Mingot-Castellano ME, Núñez R, Rodríguez-Martorell FJ
Med Clin (Barc) 2017 Apr 7;148(7):314-322. Epub 2017 Jan 22 doi: 10.1016/j.medcli.2016.11.030. PMID: 28118963
Fibrinolysis and the control of blood coagulation.
Chapin JC, Hajjar KA
Blood Rev 2015 Jan;29(1):17-24. Epub 2014 Sep 16 doi: 10.1016/j.blre.2014.09.003. PMID: 25294122Free PMC Article

Therapy

A prospective, multicenter, open-label phase III study of emicizumab prophylaxis in patients with acquired hemophilia A.
Shima M, Amano K, Ogawa Y, Yoneyama K, Ozaki R, Kobayashi R, Sakaida E, Saito M, Okamura T, Ito T, Hattori N, Higasa S, Suzuki N, Seki Y, Nogami K
J Thromb Haemost 2023 Mar;21(3):534-545. Epub 2022 Dec 22 doi: 10.1016/j.jtha.2022.10.004. PMID: 36696195
Acquired bleeding disorders.
Tiede A, Zieger B, Lisman T
Haemophilia 2022 May;28 Suppl 4:68-76. doi: 10.1111/hae.14548. PMID: 35521729
Acquired hemophilia.
García-Chávez J, Majluf-Cruz A
Gac Med Mex 2020;156(1):67-77. doi: 10.24875/GMM.19005469. PMID: 32026881
Acquired haemophilia: Epidemiology, clinical presentation, diagnosis and treatment.
Mingot-Castellano ME, Núñez R, Rodríguez-Martorell FJ
Med Clin (Barc) 2017 Apr 7;148(7):314-322. Epub 2017 Jan 22 doi: 10.1016/j.medcli.2016.11.030. PMID: 28118963
Demographic and clinical data in acquired hemophilia A: results from the European Acquired Haemophilia Registry (EACH2).
Knoebl P, Marco P, Baudo F, Collins P, Huth-Kühne A, Nemes L, Pellegrini F, Tengborn L, Lévesque H; EACH2 Registry Contributors
J Thromb Haemost 2012 Apr;10(4):622-31. doi: 10.1111/j.1538-7836.2012.04654.x. PMID: 22321904

Prognosis

Acquired bleeding disorders.
Tiede A, Zieger B, Lisman T
Haemophilia 2022 May;28 Suppl 4:68-76. doi: 10.1111/hae.14548. PMID: 35521729
Acquired hemophilia.
García-Chávez J, Majluf-Cruz A
Gac Med Mex 2020;156(1):67-77. doi: 10.24875/GMM.19005469. PMID: 32026881
Acquired hemophilia A: Updated review of evidence and treatment guidance.
Kruse-Jarres R, Kempton CL, Baudo F, Collins PW, Knoebl P, Leissinger CA, Tiede A, Kessler CM
Am J Hematol 2017 Jul;92(7):695-705. Epub 2017 Jun 5 doi: 10.1002/ajh.24777. PMID: 28470674
Acquired haemophilia: Epidemiology, clinical presentation, diagnosis and treatment.
Mingot-Castellano ME, Núñez R, Rodríguez-Martorell FJ
Med Clin (Barc) 2017 Apr 7;148(7):314-322. Epub 2017 Jan 22 doi: 10.1016/j.medcli.2016.11.030. PMID: 28118963
Fibrinolysis and the control of blood coagulation.
Chapin JC, Hajjar KA
Blood Rev 2015 Jan;29(1):17-24. Epub 2014 Sep 16 doi: 10.1016/j.blre.2014.09.003. PMID: 25294122Free PMC Article

Clinical prediction guides

Acquired Hemophilia A: Bleeding Pattern and Hemostatic Therapeutic Strategies.
Marino R
Medicina (Kaunas) 2023 Sep 28;59(10) doi: 10.3390/medicina59101739. PMID: 37893457Free PMC Article
Acquired bleeding disorders.
Tiede A, Zieger B, Lisman T
Haemophilia 2022 May;28 Suppl 4:68-76. doi: 10.1111/hae.14548. PMID: 35521729
Acquired bleeding disorders.
Tiede A, Zieger B, Lisman T
Haemophilia 2021 Feb;27 Suppl 3:5-13. Epub 2020 Jun 1 doi: 10.1111/hae.14033. PMID: 32476241
Fibrinolysis and the control of blood coagulation.
Chapin JC, Hajjar KA
Blood Rev 2015 Jan;29(1):17-24. Epub 2014 Sep 16 doi: 10.1016/j.blre.2014.09.003. PMID: 25294122Free PMC Article
Protein C.
Esmon CT
Prog Hemost Thromb 1984;7:25-54. PMID: 6099583

Recent systematic reviews

Acquired bleeding disorders secondary to immune checkpoint inhibitors: a case report and systematic literature review.
Archibald WJ, Kouides PA, Refaai MA, Lachant NA
Blood Coagul Fibrinolysis 2023 Oct 1;34(7):427-431. Epub 2023 Sep 8 doi: 10.1097/MBC.0000000000001244. PMID: 37695569
Rituximab for eradicating inhibitors in people with acquired haemophilia A.
Remmington T, Smith S
Cochrane Database Syst Rev 2021 Aug 23;8(8):CD011907. doi: 10.1002/14651858.CD011907.pub3. PMID: 34423414Free PMC Article
Mortality in congenital hemophilia A - a systematic literature review.
Hay CRM, Nissen F, Pipe SW
J Thromb Haemost 2021 Jan;19 Suppl 1(Suppl 1):6-20. doi: 10.1111/jth.15189. PMID: 33331043Free PMC Article
The prognosis and treatment of acquired hemophilia: a systematic review and meta-analysis.
Bitting RL, Bent S, Li Y, Kohlwes J
Blood Coagul Fibrinolysis 2009 Oct;20(7):517-23. doi: 10.1097/MBC.0b013e32832ca388. PMID: 19644360
Acquired factor VIII inhibitors in oncohematology: a systematic review.
Franchini M, Targher G, Manzato F, Lippi G
Crit Rev Oncol Hematol 2008 Jun;66(3):194-9. Epub 2008 Feb 19 doi: 10.1016/j.critrevonc.2007.12.004. PMID: 18243727

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