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Hypothalamic obesity

MedGen UID:
543634
•Concept ID:
C0271885
•
Disease or Syndrome
SNOMED CT: Hypothalamic obesity (82793005)

Professional guidelines

PubMed

Treatment of Acquired Hypothalamic Obesity: Now and the Future.
Dimitri P
Front Endocrinol (Lausanne) 2022;13:846880. Epub 2022 Apr 6 doi: 10.3389/fendo.2022.846880. PMID: 35464063Free PMC Article
Rare genetic causes of obesity: Diagnosis and management in clinical care.
Dubern B, Mosbah H, Pigeyre M, Clément K, Poitou C
Ann Endocrinol (Paris) 2022 Feb;83(1):63-72. Epub 2021 Dec 23 doi: 10.1016/j.ando.2021.12.003. PMID: 34953778
The Diagnosis and Treatment of Craniopharyngioma.
Müller HL
Neuroendocrinology 2020;110(9-10):753-766. Epub 2019 Nov 4 doi: 10.1159/000504512. PMID: 31678973

Recent clinical studies

Etiology

Acquired hypothalamic obesity: A clinical overview and update.
Roth CL, McCormack SE
Diabetes Obes Metab 2024 Apr;26 Suppl 2:34-45. Epub 2024 Mar 7 doi: 10.1111/dom.15530. PMID: 38450938
National UK guidelines for the management of paediatric craniopharyngioma.
Gan HW, Morillon P, Albanese A, Aquilina K, Chandler C, Chang YC, Drimtzias E, Farndon S, Jacques TS, Korbonits M, Kuczynski A, Limond J, Robinson L, Simmons I, Thomas N, Thomas S, Thorp N, Vargha-Khadem F, Warren D, Zebian B, Mallucci C, Spoudeas HA
Lancet Diabetes Endocrinol 2023 Sep;11(9):694-706. Epub 2023 Aug 4 doi: 10.1016/S2213-8587(23)00162-6. PMID: 37549682
Rare genetic causes of obesity: Diagnosis and management in clinical care.
Dubern B, Mosbah H, Pigeyre M, Clément K, Poitou C
Ann Endocrinol (Paris) 2022 Feb;83(1):63-72. Epub 2021 Dec 23 doi: 10.1016/j.ando.2021.12.003. PMID: 34953778
Update on childhood craniopharyngiomas.
Cohen LE
Curr Opin Endocrinol Diabetes Obes 2016 Aug;23(4):339-44. doi: 10.1097/MED.0000000000000264. PMID: 27258775
Hypothalamic obesity in children.
Bereket A, Kiess W, Lustig RH, Muller HL, Goldstone AP, Weiss R, Yavuz Y, Hochberg Z
Obes Rev 2012 Sep;13(9):780-98. Epub 2012 May 11 doi: 10.1111/j.1467-789X.2012.01004.x. PMID: 22577758

Diagnosis

Rare genetic causes of obesity: Diagnosis and management in clinical care.
Dubern B, Mosbah H, Pigeyre M, Clément K, Poitou C
Ann Endocrinol (Paris) 2022 Feb;83(1):63-72. Epub 2021 Dec 23 doi: 10.1016/j.ando.2021.12.003. PMID: 34953778
Childhood-onset Craniopharyngioma.
Otte A, Müller HL
J Clin Endocrinol Metab 2021 Sep 27;106(10):e3820-e3836. doi: 10.1210/clinem/dgab397. PMID: 34086900
The Diagnosis and Treatment of Craniopharyngioma.
Müller HL
Neuroendocrinology 2020;110(9-10):753-766. Epub 2019 Nov 4 doi: 10.1159/000504512. PMID: 31678973
Craniopharyngioma.
Müller HL, Merchant TE, Warmuth-Metz M, Martinez-Barbera JP, Puget S
Nat Rev Dis Primers 2019 Nov 7;5(1):75. doi: 10.1038/s41572-019-0125-9. PMID: 31699993
Hypothalamic obesity.
Babcock Gilbert S, Roth LW
Minerva Endocrinol 2015 Mar;40(1):61-70. Epub 2014 Nov 5 PMID: 25370939

Therapy

Pharmacotherapy in pediatric obesity: current evidence and landscape.
Singhal V, Sella AC, Malhotra S
Curr Opin Endocrinol Diabetes Obes 2021 Feb 1;28(1):55-63. doi: 10.1097/MED.0000000000000587. PMID: 33186194Free PMC Article
Hypothalamic obesity.
Babcock Gilbert S, Roth LW
Minerva Endocrinol 2015 Mar;40(1):61-70. Epub 2014 Nov 5 PMID: 25370939
Craniopharyngioma.
Müller HL
Handb Clin Neurol 2014;124:235-53. doi: 10.1016/B978-0-444-59602-4.00016-2. PMID: 25248591
Craniopharyngioma.
Müller HL
Endocr Rev 2014 Jun;35(3):513-43. Epub 2014 Jan 27 doi: 10.1210/er.2013-1115. PMID: 24467716
Childhood craniopharyngioma.
Müller HL
Pituitary 2013 Mar;16(1):56-67. doi: 10.1007/s11102-012-0401-0. PMID: 22678820

Prognosis

Characteristics and factors influencing hypothalamic pituitary dysfunction in patients with craniopharyngioma.
Guo Y, Pei L, Li Y, Li C, Gui S, Ni M, Liu P, Zhang Y, Zhong L
Front Endocrinol (Lausanne) 2023;14:1180591. Epub 2023 Jun 2 doi: 10.3389/fendo.2023.1180591. PMID: 37324266Free PMC Article
Quality of Life in Craniopharyngioma: A Systematic Review.
Castle-Kirszbaum M, Shi MDY, Goldschlager T
World Neurosurg 2022 Aug;164:424-435.e2. Epub 2022 May 14 doi: 10.1016/j.wneu.2022.05.038. PMID: 35580780
Childhood-onset Craniopharyngioma.
Otte A, Müller HL
J Clin Endocrinol Metab 2021 Sep 27;106(10):e3820-e3836. doi: 10.1210/clinem/dgab397. PMID: 34086900
Risk-adapted, long-term management in childhood-onset craniopharyngioma.
Müller HL
Pituitary 2017 Apr;20(2):267-281. doi: 10.1007/s11102-016-0751-0. PMID: 27604996
Craniopharyngioma.
Müller HL
Endocr Rev 2014 Jun;35(3):513-43. Epub 2014 Jan 27 doi: 10.1210/er.2013-1115. PMID: 24467716

Clinical prediction guides

Characteristics and factors influencing hypothalamic pituitary dysfunction in patients with craniopharyngioma.
Guo Y, Pei L, Li Y, Li C, Gui S, Ni M, Liu P, Zhang Y, Zhong L
Front Endocrinol (Lausanne) 2023;14:1180591. Epub 2023 Jun 2 doi: 10.3389/fendo.2023.1180591. PMID: 37324266Free PMC Article
Quality of Life in Craniopharyngioma: A Systematic Review.
Castle-Kirszbaum M, Shi MDY, Goldschlager T
World Neurosurg 2022 Aug;164:424-435.e2. Epub 2022 May 14 doi: 10.1016/j.wneu.2022.05.038. PMID: 35580780
Childhood-onset Craniopharyngioma.
Otte A, Müller HL
J Clin Endocrinol Metab 2021 Sep 27;106(10):e3820-e3836. doi: 10.1210/clinem/dgab397. PMID: 34086900
Diagnosis, Background, and Treatment of Hypothalamic Damage in Craniopharyngioma.
Erfurth EM
Neuroendocrinology 2020;110(9-10):767-779. Epub 2020 Jun 24 doi: 10.1159/000509616. PMID: 32580186Free PMC Article
Craniopharyngioma in childhood.
May JA, Krieger MD, Bowen I, Geffner ME
Adv Pediatr 2006;53:183-209. doi: 10.1016/j.yapd.2006.04.013. PMID: 17089867

Recent systematic reviews

Feasibility, safety, and efficacy of dietary or lifestyle interventions for hypothalamic obesity: A systematic review.
Van Roessel IMAA, Van Den Brink M, Dekker J, Ruitenburg-van Essen BG, Tissing WJE, van Santen HM
Clin Nutr 2024 Aug;43(8):1798-1811. Epub 2024 May 27 doi: 10.1016/j.clnu.2024.05.028. PMID: 38955055
Diagnosis and Management of Idiopathic Hypothalamic Dysfunction: A Case Series and Systematic Review.
Xu Z, Wang Y, Duan L, Yao Y, Feng F, Wang L, Deng K, You H, Yang H, Lu L, Zhu H
Neuroendocrinology 2023;113(5):479-488. Epub 2023 Feb 6 doi: 10.1159/000529537. PMID: 36746124
Quality of Life in Craniopharyngioma: A Systematic Review.
Castle-Kirszbaum M, Shi MDY, Goldschlager T
World Neurosurg 2022 Aug;164:424-435.e2. Epub 2022 May 14 doi: 10.1016/j.wneu.2022.05.038. PMID: 35580780
Interventions for the Treatment of Craniopharyngioma-Related Hypothalamic Obesity: A Systematic Review.
Ni W, Shi X
World Neurosurg 2018 Oct;118:e59-e71. Epub 2018 Jun 23 doi: 10.1016/j.wneu.2018.06.121. PMID: 29945001
The effectiveness of interventions to treat hypothalamic obesity in survivors of childhood brain tumours: a systematic review.
Wang KW, Chau R, Fleming A, Banfield L, Singh SK, Johnston DL, Zelcer SM, Rassekh SR, Burrow S, Valencia M, de Souza RJ, Thabane L, Samaan MC
Obes Rev 2017 Aug;18(8):899-914. Epub 2017 May 22 doi: 10.1111/obr.12534. PMID: 28544764

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