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Collagenous colitis

MedGen UID:
65945
•Concept ID:
C0238067
•
Disease or Syndrome
Synonyms: Colitis, Collagenous; Collagenous Colitis
SNOMED CT: CC - Collagenous colitis (19311003); Collagenous colitis (19311003)
 
Monarch Initiative: MONDO:0000703

Definition

A type of microscopic colitis of unknown etiology. It is characterized by the presence of collagen deposits in the lamina propria of the colonic mucosa. Patients present with chronic watery diarrhea. Colonoscopy reveals normal-appearing mucosa. The diagnosis is made with the microscopic examination of the colonic biopsy samples. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCollagenous colitis
Follow this link to review classifications for Collagenous colitis in Orphanet.

Professional guidelines

PubMed

Treatment of microscopic colitis: the role of budesonide and new alternatives for refractory patients.
Rojo E, Casanova MJ, Gisbert JP
Rev Esp Enferm Dig 2020 Jan;112(1):53-58. doi: 10.17235/reed.2019.6655/2019. PMID: 31880163
Microscopic colitis: pathophysiology and clinical management.
Miehlke S, Verhaegh B, Tontini GE, Madisch A, Langner C, Münch A
Lancet Gastroenterol Hepatol 2019 Apr;4(4):305-314. doi: 10.1016/S2468-1253(19)30048-2. PMID: 30860066
Prevalence, Pathogenesis, Diagnosis, and Management of Microscopic Colitis.
Gentile N, Yen EF
Gut Liver 2018 May 15;12(3):227-235. doi: 10.5009/gnl17061. PMID: 28669150Free PMC Article

Recent clinical studies

Etiology

Microscopic colitis: lymphocytic colitis, collagenous colitis, and beyond.
Yuan L, Wu TT, Zhang L
Hum Pathol 2023 Feb;132:89-101. Epub 2022 Jul 6 doi: 10.1016/j.humpath.2022.06.027. PMID: 35809686
Microscopic Colitis: A Concise Review for Clinicians.
Tome J, Kamboj AK, Pardi DS
Mayo Clin Proc 2021 May;96(5):1302-1308. doi: 10.1016/j.mayocp.2021.03.022. PMID: 33958059
Microscopic colitis: pathophysiology and clinical management.
Miehlke S, Verhaegh B, Tontini GE, Madisch A, Langner C, Münch A
Lancet Gastroenterol Hepatol 2019 Apr;4(4):305-314. doi: 10.1016/S2468-1253(19)30048-2. PMID: 30860066
Pseudomembranous colitis.
Farooq PD, Urrunaga NH, Tang DM, von Rosenvinge EC
Dis Mon 2015 May;61(5):181-206. Epub 2015 Mar 11 doi: 10.1016/j.disamonth.2015.01.006. PMID: 25769243Free PMC Article
Microscopic colitis.
Ianiro G, Cammarota G, Valerio L, Annicchiarico BE, Milani A, Siciliano M, Gasbarrini A
World J Gastroenterol 2012 Nov 21;18(43):6206-15. doi: 10.3748/wjg.v18.i43.6206. PMID: 23180940Free PMC Article

Diagnosis

Microscopic colitis: lymphocytic colitis, collagenous colitis, and beyond.
Yuan L, Wu TT, Zhang L
Hum Pathol 2023 Feb;132:89-101. Epub 2022 Jul 6 doi: 10.1016/j.humpath.2022.06.027. PMID: 35809686
Microscopic colitis.
Burke KE, D'Amato M, Ng SC, Pardi DS, Ludvigsson JF, Khalili H
Nat Rev Dis Primers 2021 Jun 10;7(1):39. doi: 10.1038/s41572-021-00273-2. PMID: 34112810
Microscopic Colitis: A Concise Review for Clinicians.
Tome J, Kamboj AK, Pardi DS
Mayo Clin Proc 2021 May;96(5):1302-1308. doi: 10.1016/j.mayocp.2021.03.022. PMID: 33958059
Microscopic colitis: pathophysiology and clinical management.
Miehlke S, Verhaegh B, Tontini GE, Madisch A, Langner C, Münch A
Lancet Gastroenterol Hepatol 2019 Apr;4(4):305-314. doi: 10.1016/S2468-1253(19)30048-2. PMID: 30860066
Pseudomembranous colitis.
Farooq PD, Urrunaga NH, Tang DM, von Rosenvinge EC
Dis Mon 2015 May;61(5):181-206. Epub 2015 Mar 11 doi: 10.1016/j.disamonth.2015.01.006. PMID: 25769243Free PMC Article

Therapy

Microscopic colitis.
Burke KE, D'Amato M, Ng SC, Pardi DS, Ludvigsson JF, Khalili H
Nat Rev Dis Primers 2021 Jun 10;7(1):39. doi: 10.1038/s41572-021-00273-2. PMID: 34112810
Microscopic Colitis: A Concise Review for Clinicians.
Tome J, Kamboj AK, Pardi DS
Mayo Clin Proc 2021 May;96(5):1302-1308. doi: 10.1016/j.mayocp.2021.03.022. PMID: 33958059
Treatment of microscopic colitis: the role of budesonide and new alternatives for refractory patients.
Rojo E, Casanova MJ, Gisbert JP
Rev Esp Enferm Dig 2020 Jan;112(1):53-58. doi: 10.17235/reed.2019.6655/2019. PMID: 31880163
Microscopic colitis: pathophysiology and clinical management.
Miehlke S, Verhaegh B, Tontini GE, Madisch A, Langner C, Münch A
Lancet Gastroenterol Hepatol 2019 Apr;4(4):305-314. doi: 10.1016/S2468-1253(19)30048-2. PMID: 30860066
Microscopic colitis.
Pardi DS
Clin Geriatr Med 2014 Feb;30(1):55-65. doi: 10.1016/j.cger.2013.10.005. PMID: 24267602

Prognosis

Microscopic Colitis: A Concise Review for Clinicians.
Tome J, Kamboj AK, Pardi DS
Mayo Clin Proc 2021 May;96(5):1302-1308. doi: 10.1016/j.mayocp.2021.03.022. PMID: 33958059
Microscopic colitis: pathophysiology and clinical management.
Miehlke S, Verhaegh B, Tontini GE, Madisch A, Langner C, Münch A
Lancet Gastroenterol Hepatol 2019 Apr;4(4):305-314. doi: 10.1016/S2468-1253(19)30048-2. PMID: 30860066
Microscopic colitis.
Bouma G, Münch A
Dig Dis 2015;33(2):208-214. Epub 2015 Apr 22 doi: 10.1159/000369517. PMID: 25925924
Pseudomembranous colitis.
Farooq PD, Urrunaga NH, Tang DM, von Rosenvinge EC
Dis Mon 2015 May;61(5):181-206. Epub 2015 Mar 11 doi: 10.1016/j.disamonth.2015.01.006. PMID: 25769243Free PMC Article
Microscopic colitis.
Pardi DS
Clin Geriatr Med 2014 Feb;30(1):55-65. doi: 10.1016/j.cger.2013.10.005. PMID: 24267602

Clinical prediction guides

Bile Acid Sequestrants in Microscopic Colitis: Clinical Outcomes and Utility of Bile Acid Testing.
Tome J, Sehgal K, Kamboj AK, Harmsen WS, Khanna S, Pardi DS
Clin Gastroenterol Hepatol 2023 Nov;21(12):3125-3131.e2. Epub 2023 May 10 doi: 10.1016/j.cgh.2023.04.031. PMID: 37172800
Analysis of Clinical and Histopathological Findings in Microscopic Colitis.
Topel G, Cakir E, Aydin I, Dilek FH, Sari AA
Turk Patoloji Derg 2022;38(3):275-283. doi: 10.5146/tjpath.2022.01574. PMID: 35642347Free PMC Article
Calprotectin in Daily Practice: Where Do We Stand in 2017?
D'Angelo F, Felley C, Frossard JL
Digestion 2017;95(4):293-301. Epub 2017 May 17 doi: 10.1159/000476062. PMID: 28511188
Microscopic colitis: a review.
Farrukh A, Mayberry JF
Colorectal Dis 2014 Dec;16(12):957-64. doi: 10.1111/codi.12716. PMID: 25039699
Frankincense: systematic review.
Ernst E
BMJ 2008 Dec 17;337:a2813. doi: 10.1136/bmj.a2813. PMID: 19091760Free PMC Article

Recent systematic reviews

Microbiome Composition in Microscopic Colitis: A Systematic Review.
Garczyk A, Mardas M, Stelmach-Mardas M
Int J Mol Sci 2023 Apr 10;24(8) doi: 10.3390/ijms24087026. PMID: 37108189Free PMC Article
Endoscopic findings and colonic perforation in microscopic colitis: A systematic review.
Marlicz W, Skonieczna-Żydecka K, Yung DE, Loniewski I, Koulaouzidis A
Dig Liver Dis 2017 Oct;49(10):1073-1085. Epub 2017 Aug 9 doi: 10.1016/j.dld.2017.07.015. PMID: 28847471
Irritable Bowel Syndrome and Microscopic Colitis: A Systematic Review and Meta-analysis.
Kamp EJ, Kane JS, Ford AC
Clin Gastroenterol Hepatol 2016 May;14(5):659-68.e1; quiz e54-5. Epub 2015 Nov 19 doi: 10.1016/j.cgh.2015.09.031. PMID: 26453949
Collagenous and lymphocytic colitis: systematic review and update of the literature.
Temmerman F, Baert F
Dig Dis 2009;27 Suppl 1:137-45. Epub 2010 Mar 4 doi: 10.1159/000268134. PMID: 20203510
Frankincense: systematic review.
Ernst E
BMJ 2008 Dec 17;337:a2813. doi: 10.1136/bmj.a2813. PMID: 19091760Free PMC Article

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