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Melanotic neuroectodermal tumor

MedGen UID:
60073
Concept ID:
C0206094
Neoplastic Process
Synonyms: Anlage Tumor, Retinal; Anlage Tumors, Retinal; Melanoameloblastoma; Melanoameloblastomas; Melanotic Neuroectodermal Tumor; Melanotic Neuroectodermal Tumors; Melanotic Progonoma; Melanotic Progonomas; Neuroectodermal Tumor, Melanotic; Neuroectodermal Tumors, Melanotic; Progonoma, Melanotic; Progonomas, Melanotic; Retinal Anlage Tumor; Retinal Anlage Tumors; Tumor, Melanotic Neuroectodermal; Tumor, Retinal Anlage; Tumors, Melanotic Neuroectodermal; Tumors, Retinal Anlage
SNOMED CT: Pigmented neuroectodermal tumor of infancy (404042005); Retinal anlage tumor (404042005); Melanotic progonoma (404042005); Melanotic neuroectodermal tumor (1513001); Retinal anlage tumor (1513001); Melanoameloblastoma (1513001); Melanotic progonoma (1513001); Melanotic neuroectodermal tumor of infancy (767047005); MNTI - melanotic neuroectodermal tumor of infancy (767047005)
 
Monarch Initiative: MONDO:0002072

Definition

A rare neoplasm usually occurring in infants. It is characterized by the presence of a mixture of melanin-containing epithelial cells and smaller neuroblast-like cells. It may involve the skull and facial bones, or the epididymis. It usually has a benign clinical course. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMelanotic neuroectodermal tumor

Professional guidelines

PubMed

Chrcanovic BR, Gomez RS
Int J Oral Maxillofac Surg 2019 Jan;48(1):1-8. Epub 2018 Aug 28 doi: 10.1016/j.ijom.2018.08.006. PMID: 30170777

Recent clinical studies

Etiology

Albuquerque DM, Cunha JL, Roza AL, Arboleda LP, Santos-Silva AR, Lopes MA, Vargas PA, Jorge J, de Almeida OP, Abrahão AC, Agostini M, Romañach MJ
Med Oral Patol Oral Cir Bucal 2021 May 1;26(3):e284-e291. doi: 10.4317/medoral.24168. PMID: 32856618Free PMC Article
Al-Obaidy KI, Alruwaii FI, Ulbright TM, Idrees MT
Hum Pathol 2020 Sep;103:25-33. Epub 2020 Jun 30 doi: 10.1016/j.humpath.2020.06.006. PMID: 32619438
Ebel F, Thieringer FM, Kunz C, Klein-Franke A, Scheinemann K, Guzman R, Soleman J
Childs Nerv Syst 2020 Apr;36(4):679-688. Epub 2020 Jan 17 doi: 10.1007/s00381-020-04509-6. PMID: 31953575
Pontes FSC, de Souza LL, Uchôa DCC, Joaquim AMC, do Nascimento LS, da Mata Rezende DDS, Pontes HAR
Head Neck 2018 Dec;40(12):2749-2756. Epub 2018 Nov 2 doi: 10.1002/hed.25514. PMID: 30390348
Moreau A, Galmiche L, Minard-Colin V, Rachwalski M, Belhous K, Orbach D, Joly A, Picard A, Kadlub N
J Craniomaxillofac Surg 2018 Feb;46(2):201-206. Epub 2017 Dec 12 doi: 10.1016/j.jcms.2017.12.001. PMID: 29275074

Diagnosis

Janardhanan M, Rakesh S, Savithri V, Aravind T, Mathew L, Ravi V
Head Neck Pathol 2023 Jun;17(2):509-514. Epub 2023 Feb 28 doi: 10.1007/s12105-023-01537-x. PMID: 36853558Free PMC Article
Bilodeau EA, Hunter KD
Head Neck Pathol 2021 Mar;15(1):71-84. Epub 2021 Mar 15 doi: 10.1007/s12105-020-01284-3. PMID: 33723756Free PMC Article
Ko E, Panchal N
Dermatol Clin 2020 Oct;38(4):485-494. doi: 10.1016/j.det.2020.05.009. PMID: 32892857
Ren Q, Chen H, Wang Y, Xu J
World Neurosurg 2019 Oct;130:170-178. Epub 2019 Jul 8 doi: 10.1016/j.wneu.2019.07.017. PMID: 31295620
Soles BS, Wilson A, Lucas DR, Heider A
Arch Pathol Lab Med 2018 Nov;142(11):1358-1363. doi: 10.5858/arpa.2018-0241-RA. PMID: 30407852

Therapy

Liang Y, Tian R, Wang J, Shan Y, Gao H, Xie C, Li J, Zhang L, Xu M, Gu S
Medicine (Baltimore) 2020 Nov 6;99(45):e22303. doi: 10.1097/MD.0000000000022303. PMID: 33157911Free PMC Article
Ko E, Panchal N
Dermatol Clin 2020 Oct;38(4):485-494. doi: 10.1016/j.det.2020.05.009. PMID: 32892857
Maroun C, Khalifeh I, Alam E, Akl PA, Saab R, Moukarbel RV
Eur Arch Otorhinolaryngol 2016 Dec;273(12):4629-4635. Epub 2016 Apr 23 doi: 10.1007/s00405-016-4066-6. PMID: 27107579
Norsted H
Acta Derm Venereol 2014 Jan;94(1):3. doi: 10.2340/00015555-1780. PMID: 24563910
Hered RW, Smithwick W 4th, Sandler E, Goldstein JD
J AAPOS 2007 Oct;11(5):504-5. Epub 2007 May 29 doi: 10.1016/j.jaapos.2007.03.010. PMID: 17532239

Prognosis

Bilodeau EA, Hunter KD
Head Neck Pathol 2021 Mar;15(1):71-84. Epub 2021 Mar 15 doi: 10.1007/s12105-020-01284-3. PMID: 33723756Free PMC Article
Emmerling MR, York TA, Caccamese JF
J Oral Maxillofac Surg 2019 Feb;77(2):315-320. Epub 2018 Oct 5 doi: 10.1016/j.joms.2018.09.033. PMID: 30392845
Pontes FSC, de Souza LL, Uchôa DCC, Joaquim AMC, do Nascimento LS, da Mata Rezende DDS, Pontes HAR
Head Neck 2018 Dec;40(12):2749-2756. Epub 2018 Nov 2 doi: 10.1002/hed.25514. PMID: 30390348
Rachidi S, Sood AJ, Patel KG, Nguyen SA, Hamilton H, Neville BW, Day TA
J Oral Maxillofac Surg 2015 Oct;73(10):1946-56. Epub 2015 Apr 7 doi: 10.1016/j.joms.2015.03.061. PMID: 25936939
Henley JD, Ferry J, Ulbright TM
Semin Diagn Pathol 2000 Nov;17(4):319-39. PMID: 11202548

Clinical prediction guides

Yindeedej V, Kittisangvara L
Pediatr Neurosurg 2021;56(3):306-311. Epub 2021 Apr 16 doi: 10.1159/000515686. PMID: 33866319
Chrcanovic BR, Gomez RS
Int J Oral Maxillofac Surg 2019 Jan;48(1):1-8. Epub 2018 Aug 28 doi: 10.1016/j.ijom.2018.08.006. PMID: 30170777
de Souza PE, Merly F, Maia DM, Castro WH, Gomez RS
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1999 Oct;88(4):466-8. doi: 10.1016/s1079-2104(99)70063-6. PMID: 10519756
Kapadia SB, Frisman DM, Hitchcock CL, Ellis GL, Popek EJ
Am J Surg Pathol 1993 Jun;17(6):566-73. doi: 10.1097/00000478-199306000-00004. PMID: 8392815
Dehner LP, Sibley RK, Sauk JJ Jr, Vickers RA, Nesbit ME, Leonard AS, Waite DE, Neeley JE, Ophoven J
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Recent systematic reviews

Vasilyeva D, Philipone E, Perschbacher SE, Chan KC
Oral Surg Oral Med Oral Pathol Oral Radiol 2022 Oct;134(4):470-483. Epub 2022 May 13 doi: 10.1016/j.oooo.2022.04.053. PMID: 35970752
Ren Q, Chen H, Wang Y, Xu J
World Neurosurg 2019 Oct;130:170-178. Epub 2019 Jul 8 doi: 10.1016/j.wneu.2019.07.017. PMID: 31295620
Chrcanovic BR, Gomez RS
Int J Oral Maxillofac Surg 2019 Jan;48(1):1-8. Epub 2018 Aug 28 doi: 10.1016/j.ijom.2018.08.006. PMID: 30170777
Rachidi S, Sood AJ, Patel KG, Nguyen SA, Hamilton H, Neville BW, Day TA
J Oral Maxillofac Surg 2015 Oct;73(10):1946-56. Epub 2015 Apr 7 doi: 10.1016/j.joms.2015.03.061. PMID: 25936939
Kruse-Lösler B, Gaertner C, Bürger H, Seper L, Joos U, Kleinheinz J
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006 Aug;102(2):204-16. Epub 2006 Jun 8 doi: 10.1016/j.tripleo.2005.08.010. PMID: 16876064

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