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intermittent explosive disorder

MedGen UID:
7116
•Concept ID:
C0021776
•
Mental or Behavioral Dysfunction
Synonyms: Disorders, Intermittent Explosive; Explosive Disorder, Intermittent; Intermittent Explosive Disorder; Intermittent Explosive Disorders
SNOMED CT: Intermittent explosive disorder (40987004)
 
Monarch Initiative: MONDO:0001521

Definition

A disorder characterized by recurrent episodes of serious assaultive acts or destruction of property due to a failure to resist aggressive impulses; the degree of aggression during these episodes is grossly out of proportion to any psychosocial provocation. The aggressive episodes are not etiologically linked to another mental disorder, a general medical condition, or substance use. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVintermittent explosive disorder

Professional guidelines

PubMed

Posterior hypothalamus as a target in the treatment of aggression: From lesioning to deep brain stimulation.
Rizzi M, Gambini O, Marras CE
Handb Clin Neurol 2021;182:95-106. doi: 10.1016/B978-0-12-819973-2.00007-1. PMID: 34266615
Validity of the new A1 and A2 criteria for DSM-5 intermittent explosive disorder.
Coccaro EF, Lee R, McCloskey MS
Compr Psychiatry 2014 Feb;55(2):260-7. Epub 2013 Oct 19 doi: 10.1016/j.comppsych.2013.09.007. PMID: 24321204
Intermittent explosive disorder: epidemiology, diagnosis and management.
Olvera RL
CNS Drugs 2002;16(8):517-26. doi: 10.2165/00023210-200216080-00002. PMID: 12096933

Recent clinical studies

Etiology

A latent class analysis of intermittent explosive disorder symptoms.
Ciesinski NK, Drabick DAG, McCloskey MS
J Affect Disord 2022 Apr 1;302:367-375. Epub 2022 Jan 29 doi: 10.1016/j.jad.2022.01.099. PMID: 35101522
Emotion attribution in intermittent explosive disorder.
Patoilo MS, Berman ME, Coccaro EF
Compr Psychiatry 2021 Apr;106:152229. Epub 2021 Feb 1 doi: 10.1016/j.comppsych.2021.152229. PMID: 33662604
Neuropsychiatric Aspects of Impulse Control Disorders.
Silva B, Canas-Simião H, Cavanna AE
Psychiatr Clin North Am 2020 Jun;43(2):249-262. Epub 2020 Apr 8 doi: 10.1016/j.psc.2020.02.001. PMID: 32439020
Emotion processing in intermittent explosive disorder.
Fahlgren MK, Puhalla AA, Sorgi KM, McCloskey MS
Psychiatry Res 2019 Mar;273:544-550. Epub 2019 Jan 14 doi: 10.1016/j.psychres.2019.01.046. PMID: 30710810
Suicidal behavior and aggression-related disorders.
McCloskey MS, Ammerman BA
Curr Opin Psychol 2018 Aug;22:54-58. Epub 2017 Aug 9 doi: 10.1016/j.copsyc.2017.08.010. PMID: 28829989

Diagnosis

Emotion attribution in intermittent explosive disorder.
Patoilo MS, Berman ME, Coccaro EF
Compr Psychiatry 2021 Apr;106:152229. Epub 2021 Feb 1 doi: 10.1016/j.comppsych.2021.152229. PMID: 33662604
Psychiatric comorbidity in Intermittent Explosive Disorder.
Coccaro EF
J Psychiatr Res 2019 Nov;118:38-43. Epub 2019 Aug 25 doi: 10.1016/j.jpsychires.2019.08.012. PMID: 31487607Free PMC Article
Emotion processing in intermittent explosive disorder.
Fahlgren MK, Puhalla AA, Sorgi KM, McCloskey MS
Psychiatry Res 2019 Mar;273:544-550. Epub 2019 Jan 14 doi: 10.1016/j.psychres.2019.01.046. PMID: 30710810
Anger in psychological disorders: Prevalence, presentation, etiology and prognostic implications.
Fernandez E, Johnson SL
Clin Psychol Rev 2016 Jun;46:124-35. Epub 2016 Apr 27 doi: 10.1016/j.cpr.2016.04.012. PMID: 27188635
Intermittent explosive disorder.
Coccaro EF
Curr Psychiatry Rep 2000 Feb;2(1):67-71. doi: 10.1007/s11920-000-0045-z. PMID: 11122935

Therapy

Pharmacotherapy of Disruptive Behaviors in Children with Intellectual Disabilities.
Hodgins GE, Winsor K, Barnhill J
Paediatr Drugs 2022 Sep;24(5):465-482. Epub 2022 Jul 4 doi: 10.1007/s40272-022-00517-y. PMID: 35781194
Pharmacotherapy of impulse control disorders: A systematic review.
Tahir T, Wong MM, Maaz M, Naufal R, Tahir R, Naidoo Y
Psychiatry Res 2022 May;311:114499. Epub 2022 Mar 7 doi: 10.1016/j.psychres.2022.114499. PMID: 35305343
The neurobiology of aggression and violence.
Rosell DR, Siever LJ
CNS Spectr 2015 Jun;20(3):254-79. Epub 2015 May 4 doi: 10.1017/S109285291500019X. PMID: 25936249
Impulsivity.
Hollander E, Rosen J
J Psychopharmacol 2000;14(2 Suppl 1):S39-44. doi: 10.1177/02698811000142S106. PMID: 10888030
Phenytoin revisited.
Finkel MJ
Clin Ther 1984;6(5):577-91. PMID: 6383610

Prognosis

ADHD symptom profiles, intermittent explosive disorder, adverse childhood experiences, and internalizing/externalizing problems in young offenders.
Barra S, Turner D, Müller M, Hertz PG, Retz-Junginger P, Tüscher O, Huss M, Retz W
Eur Arch Psychiatry Clin Neurosci 2022 Mar;272(2):257-269. Epub 2020 Aug 11 doi: 10.1007/s00406-020-01181-4. PMID: 32780159Free PMC Article
Emotion processing in intermittent explosive disorder.
Fahlgren MK, Puhalla AA, Sorgi KM, McCloskey MS
Psychiatry Res 2019 Mar;273:544-550. Epub 2019 Jan 14 doi: 10.1016/j.psychres.2019.01.046. PMID: 30710810
Comorbidity of personality disorder with intermittent explosive disorder.
Coccaro EF, Shima CK, Lee RJ
J Psychiatr Res 2018 Nov;106:15-21. Epub 2018 Aug 10 doi: 10.1016/j.jpsychires.2018.08.013. PMID: 30240963
Anger in psychological disorders: Prevalence, presentation, etiology and prognostic implications.
Fernandez E, Johnson SL
Clin Psychol Rev 2016 Jun;46:124-35. Epub 2016 Apr 27 doi: 10.1016/j.cpr.2016.04.012. PMID: 27188635
Validity of the new A1 and A2 criteria for DSM-5 intermittent explosive disorder.
Coccaro EF, Lee R, McCloskey MS
Compr Psychiatry 2014 Feb;55(2):260-7. Epub 2013 Oct 19 doi: 10.1016/j.comppsych.2013.09.007. PMID: 24321204

Clinical prediction guides

Psychiatric comorbidity in Intermittent Explosive Disorder.
Coccaro EF
J Psychiatr Res 2019 Nov;118:38-43. Epub 2019 Aug 25 doi: 10.1016/j.jpsychires.2019.08.012. PMID: 31487607Free PMC Article
Emotion processing in intermittent explosive disorder.
Fahlgren MK, Puhalla AA, Sorgi KM, McCloskey MS
Psychiatry Res 2019 Mar;273:544-550. Epub 2019 Jan 14 doi: 10.1016/j.psychres.2019.01.046. PMID: 30710810
Comorbidity of personality disorder with intermittent explosive disorder.
Coccaro EF, Shima CK, Lee RJ
J Psychiatr Res 2018 Nov;106:15-21. Epub 2018 Aug 10 doi: 10.1016/j.jpsychires.2018.08.013. PMID: 30240963
Anger in psychological disorders: Prevalence, presentation, etiology and prognostic implications.
Fernandez E, Johnson SL
Clin Psychol Rev 2016 Jun;46:124-35. Epub 2016 Apr 27 doi: 10.1016/j.cpr.2016.04.012. PMID: 27188635
Defense styles in Intermittent Explosive Disorder.
Puhalla AA, McCloskey MS, Brickman LJ, Fauber R, Coccaro EF
Psychiatry Res 2016 Apr 30;238:137-142. Epub 2016 Feb 13 doi: 10.1016/j.psychres.2016.02.019. PMID: 27086223

Recent systematic reviews

Posterior Hypothalamic Region Deep Brain Stimulation for the Treatment of Aggression Disorders in Patients with Intellectual Disability: A Systematic Review.
Cojazzi V, Innocenti N, Castelli N, Levi V, Nazzi V, Lozano A, Rizzi M
Stereotact Funct Neurosurg 2024;102(2):74-82. Epub 2024 Jan 25 doi: 10.1159/000535105. PMID: 38272011
Exploring the Impact of Family Separation on Refugee Mental Health: A Systematic Review and Meta-narrative Analysis.
Ali-Naqvi O, Alburak TA, Selvan K, Abdelmeguid H, Malvankar-Mehta MS
Psychiatr Q 2023 Mar;94(1):61-77. Epub 2023 Jan 24 doi: 10.1007/s11126-022-10013-8. PMID: 36690848
Pharmacotherapy of impulse control disorders: A systematic review.
Tahir T, Wong MM, Maaz M, Naufal R, Tahir R, Naidoo Y
Psychiatry Res 2022 May;311:114499. Epub 2022 Mar 7 doi: 10.1016/j.psychres.2022.114499. PMID: 35305343
Efficacy of mood stabilisers in the treatment of impulsive or repetitive aggression: systematic review and meta-analysis.
Jones RM, Arlidge J, Gillham R, Reagu S, van den Bree M, Taylor PJ
Br J Psychiatry 2011 Feb;198(2):93-8. doi: 10.1192/bjp.bp.110.083030. PMID: 21282779

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