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Hepatitis, Animal

MedGen UID:
42423
•Concept ID:
C0019188
•
Disease or Syndrome
Synonyms: Animal Hepatitides; Animal Hepatitis; Hepatitides, Animal

Definition

INFLAMMATION of the LIVER in non-human animals. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHepatitis, Animal

Professional guidelines

PubMed

Chronic hepatitis. Aetiology and current management.
Cooksley WG, Bradbear RA, Halliday JW, Powell LW
Drugs 1984 Jun;27(6):579-84. doi: 10.2165/00003495-198427060-00004. PMID: 6734469

Recent clinical studies

Etiology

Resveratrol modulates Toxoplasma gondii infection induced liver injury by intervening in the HMGB1/TLR4/NF-κB signaling pathway.
Lu JM, Jin GN, Lu YN, Zhao XD, Lan HW, Mu SR, Shen XY, Xu GH, Jin CH, Ma J, Jin X, Xu X, Piao LX
Eur J Pharmacol 2021 Nov 5;910:174497. Epub 2021 Sep 9 doi: 10.1016/j.ejphar.2021.174497. PMID: 34508751
Therapeutic effects of AdipoRon on liver inflammation and fibrosis induced by CCl(4) in mice.
Sha M, Gao Y, Deng C, Wan Y, Zhuang Y, Hu X, Wang Y
Int Immunopharmacol 2020 Feb;79:106157. Epub 2020 Jan 5 doi: 10.1016/j.intimp.2019.106157. PMID: 31911372
Chronic hepatitis in Doberman pinschers. A review.
Mandigers PJ, van den Ingh TS, Spee B, Penning LC, Bode P, Rothuizen J
Vet Q 2004 Sep;26(3):98-106. doi: 10.1080/01652176.2004.9695173. PMID: 15559390
Current biochemical studies of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis suggest a new therapeutic approach.
Hookman P, Barkin JS
Am J Gastroenterol 2003 Sep;98(9):2093-7. doi: 10.1111/j.1572-0241.2003.07670.x. PMID: 14499793
Autoimmune hepatitis. Definition--classification--histopathology--immunopathogenesis.
Meyer zum Büschenfelde KH, Dienes HP
Virchows Arch 1996 Sep;429(1):1-12. doi: 10.1007/BF00196814. PMID: 8865847

Diagnosis

The pseudokinase MLKL regulates hepatic insulin sensitivity independently of inflammation.
Xu H, Du X, Liu G, Huang S, Du W, Zou S, Tang D, Fan C, Xie Y, Wei Y, Tian Y, Fu X
Mol Metab 2019 May;23:14-23. Epub 2019 Feb 20 doi: 10.1016/j.molmet.2019.02.003. PMID: 30837196Free PMC Article
Canine Copper-Associated Hepatitis.
Dirksen K, Fieten H
Vet Clin North Am Small Anim Pract 2017 May;47(3):631-644. Epub 2017 Jan 5 doi: 10.1016/j.cvsm.2016.11.011. PMID: 28063745
Autoimmune hepatitis. Definition--classification--histopathology--immunopathogenesis.
Meyer zum Büschenfelde KH, Dienes HP
Virchows Arch 1996 Sep;429(1):1-12. doi: 10.1007/BF00196814. PMID: 8865847
Current concepts of acute and chronic viral hepatitis.
deBelle RC, Lester R
Pediatr Clin North Am 1975 Nov;22(4):943-61. doi: 10.1016/s0031-3955(16)33217-5. PMID: 172845
Hepatitis-associated antigen.
Shulman NR
Am J Med 1970 Nov;49(5):669-92. doi: 10.1016/s0002-9343(70)80133-4. PMID: 4250361Free PMC Article

Therapy

1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol (PLAG) reduces hepatic injury in concanavalin A-treated mice.
Ko YE, Yoon SY, Ly SY, Kim JH, Sohn KY, Kim JW
J Cell Biochem 2018 Feb;119(2):1392-1405. Epub 2017 Nov 16 doi: 10.1002/jcb.26299. PMID: 28749086
Canine Copper-Associated Hepatitis.
Dirksen K, Fieten H
Vet Clin North Am Small Anim Pract 2017 May;47(3):631-644. Epub 2017 Jan 5 doi: 10.1016/j.cvsm.2016.11.011. PMID: 28063745
5-Aminoimidazole-4-carboxamide-1-β-D-ribofuranoside-attenuates LPS/D-Gal-induced acute hepatitis in mice.
Zhou D, Ai Q, Lin L, Gong X, Ge P, Che Q, Wan J, Wen A, Zhang L
Innate Immun 2015 Oct;21(7):698-705. Epub 2015 May 15 doi: 10.1177/1753425915586231. PMID: 25979627
Chronic hepatitis in Doberman pinschers. A review.
Mandigers PJ, van den Ingh TS, Spee B, Penning LC, Bode P, Rothuizen J
Vet Q 2004 Sep;26(3):98-106. doi: 10.1080/01652176.2004.9695173. PMID: 15559390
Hepatitis-associated antigen.
Shulman NR
Am J Med 1970 Nov;49(5):669-92. doi: 10.1016/s0002-9343(70)80133-4. PMID: 4250361Free PMC Article

Prognosis

Modification of chemokine pathways and immune cell infiltration as a novel therapeutic approach in liver inflammation and fibrosis.
Zimmermann HW, Tacke F
Inflamm Allergy Drug Targets 2011 Dec;10(6):509-36. doi: 10.2174/187152811798104890. PMID: 22150762
Current biochemical studies of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis suggest a new therapeutic approach.
Hookman P, Barkin JS
Am J Gastroenterol 2003 Sep;98(9):2093-7. doi: 10.1111/j.1572-0241.2003.07670.x. PMID: 14499793
Imaging of apoptosis (programmed cell death) with 99mTc annexin V.
Blankenberg FG, Katsikis PD, Tait JF, Davis RE, Naumovski L, Ohtsuki K, Kopiwoda S, Abrams MJ, Strauss HW
J Nucl Med 1999 Jan;40(1):184-91. PMID: 9935075
Autoimmune hepatitis. Definition--classification--histopathology--immunopathogenesis.
Meyer zum Büschenfelde KH, Dienes HP
Virchows Arch 1996 Sep;429(1):1-12. doi: 10.1007/BF00196814. PMID: 8865847
Hepatitis-associated antigen.
Shulman NR
Am J Med 1970 Nov;49(5):669-92. doi: 10.1016/s0002-9343(70)80133-4. PMID: 4250361Free PMC Article

Clinical prediction guides

The LPS Responsiveness in BN and LEW Rats and Its Severity Are Modulated by the Liver.
Fang H, Jin H, Hua C, Liu A, Song Z, Chen X, Dirsch O, Dahmen U
J Immunol Res 2018;2018:6328713. Epub 2018 Jul 30 doi: 10.1155/2018/6328713. PMID: 30151394Free PMC Article
Interobserver Agreement Using Histological Scoring of the Canine Liver.
Lidbury JA, Rodrigues Hoffmann A, Ivanek R, Cullen JM, Porter BF, Oliveira F, Van Winkle TJ, Grinwis GC, Sucholdolski JS, Steiner JM
J Vet Intern Med 2017 May;31(3):778-783. Epub 2017 Mar 14 doi: 10.1111/jvim.14684. PMID: 28295598Free PMC Article
STK4 regulates TLR pathways and protects against chronic inflammation-related hepatocellular carcinoma.
Li W, Xiao J, Zhou X, Xu M, Hu C, Xu X, Lu Y, Liu C, Xue S, Nie L, Zhang H, Li Z, Zhang Y, Ji F, Hui L, Tao W, Wei B, Wang H
J Clin Invest 2015 Nov 2;125(11):4239-54. Epub 2015 Oct 12 doi: 10.1172/JCI81203. PMID: 26457732Free PMC Article
Autoimmune hepatitis. Definition--classification--histopathology--immunopathogenesis.
Meyer zum Büschenfelde KH, Dienes HP
Virchows Arch 1996 Sep;429(1):1-12. doi: 10.1007/BF00196814. PMID: 8865847
Animal models of ethanol dependence and liver injury in rats and baboons.
Lieber CS, Decarli LM
Fed Proc 1976 Apr;35(5):1232-6. PMID: 944146

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