U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Glomus tumor

MedGen UID:
4903
•Concept ID:
C0017653
•
Neoplastic Process
Synonyms: Glomus Tumor; Glomus Tumors; Tumor, Glomus; Tumors, Glomus
SNOMED CT: Glomus tumor (403969002); Glomus tumor (10438002)
 
Monarch Initiative: MONDO:0018327
Orphanet: ORPHA391651

Definition

A rare soft tissue tumor characterized by a nodular lesion composed of cells closely resembling the modified smooth muscle cells of the normal glomus body. The tumors most often arise in the skin or soft tissues of the distal extremities, in particular the subungual region, but have been reported in almost any location. They occur as typical glomus tumors, glomangiomatosis (multiple nodules of solid glomus tumor investing the vascular walls), symplastic (showing striking nuclear atypia without mitotic activity or necrosis) or malignant glomus tumors, and glomus tumors of uncertain malignant potential. [from ORDO]

Professional guidelines

PubMed

Diagnosis and surgical treatment of benign nail unit tumors.
Starace M, Rubin AI, Di Chiacchio NG, Pampaloni F, Alessandrini A, Piraccini BM, Iorizzo M
J Dtsch Dermatol Ges 2023 Feb;21(2):116-129. doi: 10.1111/ddg.14942. PMID: 36808456
Management of the Hand Tumors.
Datta NK, Das KP, Aish PK, Datta M, Banik SK, Sen SK, Chowdhury RM
Mymensingh Med J 2023 Jan;32(1):135-143. PMID: 36594313
Contemporary management of jugular paragangliomas.
Wanna GB, Sweeney AD, Haynes DS, Carlson ML
Otolaryngol Clin North Am 2015 Apr;48(2):331-41. doi: 10.1016/j.otc.2014.12.007. PMID: 25769354

Recent clinical studies

Etiology

Management of the Hand Tumors.
Datta NK, Das KP, Aish PK, Datta M, Banik SK, Sen SK, Chowdhury RM
Mymensingh Med J 2023 Jan;32(1):135-143. PMID: 36594313
Paragangliomas of the head and neck.
Valero C, Ganly I
J Oral Pathol Med 2022 Nov;51(10):897-903. Epub 2022 Feb 23 doi: 10.1111/jop.13286. PMID: 35178777
Radiotherapy of benign intracranial tumours.
Dissaux G, Josset S, Thillays F, Lucia F, Bourbonne V, Pradier O, Pasquier D, Biau J
Cancer Radiother 2022 Feb-Apr;26(1-2):137-146. Epub 2021 Dec 22 doi: 10.1016/j.canrad.2021.08.005. PMID: 34953692
Acral manifestations of soft tissue tumors.
Paral KM, Petronic-Rosic V
Clin Dermatol 2017 Jan-Feb;35(1):85-98. Epub 2016 Sep 10 doi: 10.1016/j.clindermatol.2016.09.012. PMID: 27938817
Contemporary management of jugular paragangliomas.
Wanna GB, Sweeney AD, Haynes DS, Carlson ML
Otolaryngol Clin North Am 2015 Apr;48(2):331-41. doi: 10.1016/j.otc.2014.12.007. PMID: 25769354

Diagnosis

Glomuvenous Malformation.
Huang JS, Wang D
J Pediatr Gastroenterol Nutr 2023 Apr 1;76(4):e81. Epub 2022 Dec 27 doi: 10.1097/MPG.0000000000003691. PMID: 36728817
Glomus tumour.
Sethu C, Sethu AU
Ann R Coll Surg Engl 2016 Jan;98(1):e1-2. doi: 10.1308/rcsann.2016.0005. PMID: 26688416Free PMC Article
Sellar glomangioma.
Ebinu JO, Shahideh M, Ibrahim GM, Vescan A, Gentili F, Ridout R, Asa S, Zadeh G
Endocr Pathol 2011 Dec;22(4):218-21. doi: 10.1007/s12022-011-9179-2. PMID: 21912963
Glomus tumor.
Gombos Z, Zhang PJ
Arch Pathol Lab Med 2008 Sep;132(9):1448-52. doi: 10.5858/2008-132-1448-GT. PMID: 18788860
Glomus tumors.
McDermott EM, Weiss AP
J Hand Surg Am 2006 Oct;31(8):1397-400. doi: 10.1016/j.jhsa.2006.05.018. PMID: 17027805

Therapy

Unusual gastric tumors and tumor-like lesions: Radiological with pathological correlation and literature review.
Lin YM, Chiu NC, Li AF, Liu CA, Chou YH, Chiou YY
World J Gastroenterol 2017 Apr 14;23(14):2493-2504. doi: 10.3748/wjg.v23.i14.2493. PMID: 28465633Free PMC Article
DIAGNOSIS OF ENDOCRINE DISEASE: Expanding the cause of hypopituitarism.
Pekic S, Popovic V
Eur J Endocrinol 2017 Jun;176(6):R269-R282. Epub 2017 Mar 3 doi: 10.1530/EJE-16-1065. PMID: 28258131
Preoperative tumor embolization.
Ashour R, Aziz-Sultan A
Neurosurg Clin N Am 2014 Jul;25(3):607-17. Epub 2014 May 20 doi: 10.1016/j.nec.2014.04.015. PMID: 24994094
The association between glomus tumors and neurofibromatosis.
Harrison B, Moore AM, Calfee R, Sammer DM
J Hand Surg Am 2013 Aug;38(8):1571-4. Epub 2013 Jul 9 doi: 10.1016/j.jhsa.2013.05.025. PMID: 23849732
Pulmonary glomus tumor.
Dalfior D, Parisi A, Cannizzaro C, Bontempini L, Di Pace C, Menestrina F, Dalla Palma P, Barbareschi M
Int J Surg Pathol 2008 Jan;16(1):81-4. doi: 10.1177/1066896907304520. PMID: 18203793

Prognosis

Management of the Hand Tumors.
Datta NK, Das KP, Aish PK, Datta M, Banik SK, Sen SK, Chowdhury RM
Mymensingh Med J 2023 Jan;32(1):135-143. PMID: 36594313
Clinical and onychoscopic characteristics of subungual glomus tumor: a cross-sectional study.
Grover C, Jayasree P, Kaliyadan F
Int J Dermatol 2021 Jun;60(6):693-702. Epub 2020 Dec 17 doi: 10.1111/ijd.15358. PMID: 33332614
Characteristics and prognosis of glomangiopericytomas: A systematic review.
Park ES, Kim J, Jun SY
Head Neck 2017 Sep;39(9):1897-1909. Epub 2017 May 12 doi: 10.1002/hed.24818. PMID: 28497509
Symplastic Glomus Tumor.
Kabukçuoğlu F, Özkayalar H, Sakiz D, Kabukçuoğlu Y
Turk Patoloji Derg 2015;31(3):211-4. doi: 10.5146/tjpath.2014.01247. PMID: 26456968
Nail tumors.
Richert B, Lecerf P, Caucanas M, André J
Clin Dermatol 2013 Sep-Oct;31(5):602-17. doi: 10.1016/j.clindermatol.2013.06.014. PMID: 24079590

Clinical prediction guides

Paragangliomas of the head and neck.
Valero C, Ganly I
J Oral Pathol Med 2022 Nov;51(10):897-903. Epub 2022 Feb 23 doi: 10.1111/jop.13286. PMID: 35178777
Radiotherapy of benign intracranial tumours.
Dissaux G, Josset S, Thillays F, Lucia F, Bourbonne V, Pradier O, Pasquier D, Biau J
Cancer Radiother 2022 Feb-Apr;26(1-2):137-146. Epub 2021 Dec 22 doi: 10.1016/j.canrad.2021.08.005. PMID: 34953692
Clinical and onychoscopic characteristics of subungual glomus tumor: a cross-sectional study.
Grover C, Jayasree P, Kaliyadan F
Int J Dermatol 2021 Jun;60(6):693-702. Epub 2020 Dec 17 doi: 10.1111/ijd.15358. PMID: 33332614
Symplastic Glomus Tumor.
Kabukçuoğlu F, Özkayalar H, Sakiz D, Kabukçuoğlu Y
Turk Patoloji Derg 2015;31(3):211-4. doi: 10.5146/tjpath.2014.01247. PMID: 26456968
Cutaneous myofibroma.
Smith KJ, Skelton HG, Barrett TL, Lupton GP, Graham JH
Mod Pathol 1989 Nov;2(6):603-9. PMID: 2587567

Recent systematic reviews

Glomus Tumor of the Stomach: A Systematic Review and Illustrative Case Report.
Pansa A, Samà L, Ruspi L, Sicoli F, Cananzi FCM, Quagliuolo V
Dig Dis 2023;41(1):17-33. Epub 2022 Jun 26 doi: 10.1159/000525513. PMID: 35753305
Primary Paraganglioma of the Facial Canal: An Evidence-Based Approach.
Yuhan BT, Trang A, Hutz MJ, Leonetti JP
Otolaryngol Head Neck Surg 2020 Apr;162(4):458-468. Epub 2020 Feb 25 doi: 10.1177/0194599820907303. PMID: 32093508
Primary Hand Leiomyoma: A Systematic Review.
Oliver JD, Boczar D, Huayllani MT, Restrepo DJ, Sisti A, Manrique OJ, Broer PN, Forte AJ
Ann Plast Surg 2019 Dec;83(6):e77-e84. doi: 10.1097/SAP.0000000000002004. PMID: 31599787
Characteristics and prognosis of glomangiopericytomas: A systematic review.
Park ES, Kim J, Jun SY
Head Neck 2017 Sep;39(9):1897-1909. Epub 2017 May 12 doi: 10.1002/hed.24818. PMID: 28497509

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Reviews

    Related information

    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...