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Invasive hydatidiform mole

MedGen UID:
3055
•Concept ID:
C0008493
•
Neoplastic Process
Synonyms: Chorioadenoma; Chorioadenomas; Hydatidiform Mole, Invasive; Hydatidiform Moles, Invasive; Invasive Hydatidiform Mole; Invasive Hydatidiform Moles; Invasive Mole; Invasive Moles; Mole, Invasive; Mole, Invasive Hydatidiform; Moles, Invasive; Moles, Invasive Hydatidiform
SNOMED CT: Invasive hydatidiform mole (416669000); Chorioadenoma (416669000); Chorioadenoma destruens (416669000); IM - Invasive mole (416669000); Invasive mole (416669000); Invasive mole - placenta (416669000); Invasive hydatidiform mole (18799007); Malignant hydatidiform mole (18799007); Chorioadenoma destruens (18799007); Chorioadenoma (18799007); Invasive mole (18799007)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0020549
Orphanet: ORPHA99925

Definition

A form of gestational trophoblastic neoplasia similar to a hydatidiform mole but with deep invasion into the myometriumand histologically characterized hyperplasia of trophoblasts, generalized cystic degeneration of chorionic villi and the presence of molar villi in the myometrium and/ or uterine blood vessels. Indicative signs include persistent unexplained metrorrhagia or secondary increase, stagnation, or non-normalization at 6 months of total serum chorionic gonadotropin (hCG) levels after evacuation of a hydatidiform mole. Metastases (in the lungs or vagina) may be observed. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVInvasive hydatidiform mole

Professional guidelines

PubMed

Gestational trophoblastic neoplasia: does centralization of care impact clinical management?
Mitric C, Yang K, Bhat G, Lheureux S, Laframboise S, Li X, Bouchard-Fortier G
Int J Gynecol Cancer 2023 Nov 6;33(11):1724-1732. doi: 10.1136/ijgc-2023-004526. PMID: 37723102
Angiogenin and MMP-2 as potential biomarkers in the differential diagnosis of gestational trophoblastic diseases.
Weng D, Han T, Dong J, Zhang M, Mi Y, He Y, Li X, Zhu X
Medicine (Baltimore) 2022 Feb 4;101(5):e28768. doi: 10.1097/MD.0000000000028768. PMID: 35119039Free PMC Article
Combination chemotherapy for primary treatment of high-risk gestational trophoblastic tumour.
Deng L, Zhang J, Wu T, Lawrie TA
Cochrane Database Syst Rev 2013 Jan 31;2013(1):CD005196. doi: 10.1002/14651858.CD005196.pub4. PMID: 23440800Free PMC Article

Recent clinical studies

Etiology

Invasive and metastatic hydatidiform moles in Slovakia in 1993‒2022.
McCullough L, Danihel L, Sufliarsky J, Kubickova M, Niznanska Z, Adamec A, Korbel M
Bratisl Lek Listy 2024;125(7):423-428. doi: 10.4149/BLL_2024_65. PMID: 38943503
Histopathological and clinical features of molar pregnancy.
Heřman J, Rob L, Robová H, Drochýtek V, Hruda M, Pichlík T, Kujal P, Drozenová J
Ceska Gynekol 2019 Winter;84(6):418-424. PMID: 31948249
Predictive value of some hematological parameters for non-invasive and invasive mole pregnancies.
Abide Yayla C, Özkaya E, Yenidede I, Eser A, Ergen EB, Tayyar AT, Şentürk MB, Karateke A
J Matern Fetal Neonatal Med 2018 Feb;31(3):271-277. Epub 2017 Feb 2 doi: 10.1080/14767058.2017.1281906. PMID: 28093002
Combination chemotherapy for primary treatment of high-risk gestational trophoblastic tumour.
Deng L, Zhang J, Wu T, Lawrie TA
Cochrane Database Syst Rev 2013 Jan 31;2013(1):CD005196. doi: 10.1002/14651858.CD005196.pub4. PMID: 23440800Free PMC Article
Gestational trophoblastic neoplasms.
Hilgers RD, Lewis JL Jr
Gynecol Oncol 1974 Dec;2(4):460-75. doi: 10.1016/0090-8258(74)90055-9. PMID: 4376997

Diagnosis

Cornual invasive hydatidiform mole: a rare case report and literature review.
Qian J, Xu S, Chen L
BMC Womens Health 2023 Nov 2;23(1):566. doi: 10.1186/s12905-023-02727-z. PMID: 37919704Free PMC Article
Invasive Mole After Incomplete Miscarriage.
Habek D
Z Geburtshilfe Neonatol 2022 Aug;226(4):282. Epub 2022 Mar 9 doi: 10.1055/a-1742-3767. PMID: 35263771
Invasive mole with lung metastasis after an abdominal complete hydatidiform mole treatment.
Suzuki S, Takahashi K, Obayashi S, Kitazawa M, Kuroda H, Fukasawa I
J Obstet Gynaecol Res 2021 Jan;47(1):420-424. Epub 2020 Oct 20 doi: 10.1111/jog.14537. PMID: 33078868
Histopathological and clinical features of molar pregnancy.
Heřman J, Rob L, Robová H, Drochýtek V, Hruda M, Pichlík T, Kujal P, Drozenová J
Ceska Gynekol 2019 Winter;84(6):418-424. PMID: 31948249
Gestational trophoblastic neoplasms.
Hilgers RD, Lewis JL Jr
Gynecol Oncol 1974 Dec;2(4):460-75. doi: 10.1016/0090-8258(74)90055-9. PMID: 4376997

Therapy

Combination chemotherapy for primary treatment of high-risk gestational trophoblastic tumour.
Deng L, Zhang J, Wu T, Lawrie TA
Cochrane Database Syst Rev 2013 Jan 31;2013(1):CD005196. doi: 10.1002/14651858.CD005196.pub4. PMID: 23440800Free PMC Article
Invasive mole.
Franke HR, Vermorken JB, von Kessel H, Dijkhuizen GH, Calame JJ, Stolk JG
Eur J Obstet Gynecol Reprod Biol 1986 Mar;21(3):181-5. doi: 10.1016/0028-2243(86)90034-1. PMID: 3007229
Invasive mole.
Lurain JR, Brewer JI
Semin Oncol 1982 Jun;9(2):174-80. PMID: 6289460
Letter: Hydatidiform mole.
Dawood MY
Obstet Gynecol 1976 Feb;47(2):251-2. PMID: 175323
Gestational trophoblastic neoplasms.
Hilgers RD, Lewis JL Jr
Gynecol Oncol 1974 Dec;2(4):460-75. doi: 10.1016/0090-8258(74)90055-9. PMID: 4376997

Prognosis

Invasive and metastatic hydatidiform moles in Slovakia in 1993‒2022.
McCullough L, Danihel L, Sufliarsky J, Kubickova M, Niznanska Z, Adamec A, Korbel M
Bratisl Lek Listy 2024;125(7):423-428. doi: 10.4149/BLL_2024_65. PMID: 38943503
Gut Microbial Diversity in Female Patients With Invasive Mole and Choriocarcinoma and Its Differences Versus Healthy Controls.
Liu X, Pan X, Liu H, Ma X
Front Cell Infect Microbiol 2021;11:704100. Epub 2021 Aug 26 doi: 10.3389/fcimb.2021.704100. PMID: 34513727Free PMC Article
Predictive value of some hematological parameters for non-invasive and invasive mole pregnancies.
Abide Yayla C, Özkaya E, Yenidede I, Eser A, Ergen EB, Tayyar AT, Şentürk MB, Karateke A
J Matern Fetal Neonatal Med 2018 Feb;31(3):271-277. Epub 2017 Feb 2 doi: 10.1080/14767058.2017.1281906. PMID: 28093002
Trophoblastic tumors--prognostic factors.
Jones WB
Cancer 1981 Jul 15;48(2 Suppl):602-7. doi: 10.1002/1097-0142(19810715)48:1+<602::aid-cncr2820481326>3.0.co;2-8. PMID: 6268287
Letter: Hydatidiform mole.
Dawood MY
Obstet Gynecol 1976 Feb;47(2):251-2. PMID: 175323

Clinical prediction guides

Combined analysis of clinical features, human chorionic gonadotropin (hCG) value, and hCG ratios for early prediction of postmolar gestational trophoblastic neoplasia.
Rakprasit C, Ruengkhachorn I, Therasakvichya S, Inthasorn P, Achariyapota V, Kuljarasnont S, Khemworapong K, Jareemit N
Arch Gynecol Obstet 2023 Apr;307(4):1145-1154. Epub 2022 Sep 18 doi: 10.1007/s00404-022-06785-w. PMID: 36116082
Gut Microbial Diversity in Female Patients With Invasive Mole and Choriocarcinoma and Its Differences Versus Healthy Controls.
Liu X, Pan X, Liu H, Ma X
Front Cell Infect Microbiol 2021;11:704100. Epub 2021 Aug 26 doi: 10.3389/fcimb.2021.704100. PMID: 34513727Free PMC Article
Predictive value of some hematological parameters for non-invasive and invasive mole pregnancies.
Abide Yayla C, Özkaya E, Yenidede I, Eser A, Ergen EB, Tayyar AT, Şentürk MB, Karateke A
J Matern Fetal Neonatal Med 2018 Feb;31(3):271-277. Epub 2017 Feb 2 doi: 10.1080/14767058.2017.1281906. PMID: 28093002
Multicenter analysis of gestational trophoblastic neoplasia in Turkey.
Ozalp SS, Telli E, Oge T, Tulunay G, Boran N, Turan T, Yenen M, Kurdoglu Z, Ozler A, Yuce K, Ulker V, Arvas M, Demirkiran F, Bese T, Tokgozoglu N, Onan A, Sanci M, Gokcu M, Tosun G, Dikmen Y, Ozsaran A, Terek MC, Akman L, Yetimalar H, Kilic DS, Gungor T, Ozgu E, Yildiz Y, Kokcu A, Kefeli M, Kuruoglu S, Yuksel H, Guvenal T, Hasdemir PS, Ozcelik B, Serin S, Dolanbay M, Arioz DT, Tuncer N, Bozkaya H, Guven S, Kulaksiz D, Varol F, Yanik A, Ogurlu G, Simsek T, Toptas T, Dogan S, Camuzoglu H, Api M, Guzin K, Caliskan E, Doger E, Cakmak B, Ilhan TT
Asian Pac J Cancer Prev 2014;15(8):3625-8. doi: 10.7314/apjcp.2014.15.8.3625. PMID: 24870768
New discoveries on the biology and detection of human chorionic gonadotropin.
Cole LA
Reprod Biol Endocrinol 2009 Jan 26;7:8. doi: 10.1186/1477-7827-7-8. PMID: 19171054Free PMC Article

Recent systematic reviews

Invasive mole in a perimenopausal woman: a case report and systematic review.
von Welser SF, Grube M, Ortmann O
Arch Gynecol Obstet 2015 Dec;292(6):1193-9. Epub 2015 Jun 7 doi: 10.1007/s00404-015-3777-z. PMID: 26050078
Combination chemotherapy for primary treatment of high-risk gestational trophoblastic tumour.
Deng L, Zhang J, Wu T, Lawrie TA
Cochrane Database Syst Rev 2013 Jan 31;2013(1):CD005196. doi: 10.1002/14651858.CD005196.pub4. PMID: 23440800Free PMC Article

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