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Abnormal enteric neuron morphology

MedGen UID:: 927579
•Concept ID:: C4293670
•: Cell or Molecular Dysfunction

Synonym:	Abnormality of enteric neuron morphology

HPO:	HP:0025029

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVAbnormal enteric neuron morphology

Congenital Systemic Disorder
- Abnormality of the nervous system
  - Abnormality of the peripheral nervous system
    - Abnormality of the autonomic nervous system
      - Abnormal autonomic nervous system morphology
        Abnormal enteric nervous system morphology
        Abnormal enteric neuron morphology
        Enteric intraneuronal nuclear inclusion bodies
        Enteric neuronal degeneration

Professional guidelines

PubMed

Optimizing neurogenic potential of enteric neurospheres for treatment of neurointestinal diseases.

Cheng LS, Graham HK, Pan WH, Nagy N, Carreon-Rodriguez A, Goldstein AM, Hotta R
J Surg Res 2016 Dec;206(2):451-459. Epub 2016 Aug 12 doi: 10.1016/j.jss.2016.08.035. PMID: 27884342 Free PMC Article

White paper on guidelines concerning enteric nervous system stem cell therapy for enteric neuropathies.

Burns AJ, Goldstein AM, Newgreen DF, Stamp L, Schäfer KH, Metzger M, Hotta R, Young HM, Andrews PW, Thapar N, Belkind-Gerson J, Bondurand N, Bornstein JC, Chan WY, Cheah K, Gershon MD, Heuckeroth RO, Hofstra RM, Just L, Kapur RP, King SK, McCann CJ, Nagy N, Ngan E, Obermayr F, Pachnis V, Pasricha PJ, Sham MH, Tam P, Vanden Berghe P
Dev Biol 2016 Sep 15;417(2):229-51. Epub 2016 Apr 5 doi: 10.1016/j.ydbio.2016.04.001. PMID: 27059883 Free PMC Article

Clinical aspects of neurointestinal disease: Pathophysiology, diagnosis, and treatment.

Goldstein AM, Thapar N, Karunaratne TB, De Giorgio R
Dev Biol 2016 Sep 15;417(2):217-28. Epub 2016 Apr 6 doi: 10.1016/j.ydbio.2016.03.032. PMID: 27059882

See all (10)

Recent clinical studies

Etiology

RET enhancer haplotype-dependent remodeling of the human fetal gut development program.

Chatterjee S, Fries LE, Yaacov O, Hu N, Berk-Rauch HE, Chakravarti A
PLoS Genet 2023 Nov;19(11):e1011030. Epub 2023 Nov 10 doi: 10.1371/journal.pgen.1011030. PMID: 37948459 Free PMC Article

PTEN Immunohistochemistry.

Terra SA, de Arruda Lourenção PLT, Rodrigues MAM
Arch Pathol Lab Med 2022 May 1;147(5):577-583. doi: 10.5858/arpa.2021-0424-OA. PMID: 35943858

Effects of Serotonin and Slow-Release 5-Hydroxytryptophan on Gastrointestinal Motility in a Mouse Model of Depression.

Israelyan N, Del Colle A, Li Z, Park Y, Xing A, Jacobsen JPR, Luna RA, Jensen DD, Madra M, Saurman V, Rahim R, Latorre R, Law K, Carson W, Bunnett NW, Caron MG, Margolis KG
Gastroenterology 2019 Aug;157(2):507-521.e4. Epub 2019 May 7 doi: 10.1053/j.gastro.2019.04.022. PMID: 31071306 Free PMC Article

Parkinson's disease from the gut.

Liddle RA
Brain Res 2018 Aug 15;1693(Pt B):201-206. Epub 2018 Jan 31 doi: 10.1016/j.brainres.2018.01.010. PMID: 29360467 Free PMC Article

Variant Hirschsprung's disease.

Puri P, Rolle U
Semin Pediatr Surg 2004 Nov;13(4):293-9. doi: 10.1053/j.sempedsurg.2004.10.017. PMID: 15660323

See all (68)

Diagnosis

PTEN Immunohistochemistry.

Terra SA, de Arruda Lourenção PLT, Rodrigues MAM
Arch Pathol Lab Med 2022 May 1;147(5):577-583. doi: 10.5858/arpa.2021-0424-OA. PMID: 35943858

The developmental etiology and pathogenesis of Hirschsprung disease.

Butler Tjaden NE, Trainor PA
Transl Res 2013 Jul;162(1):1-15. Epub 2013 Mar 22 doi: 10.1016/j.trsl.2013.03.001. PMID: 23528997 Free PMC Article

Gastroparesis.

Hasler WL
Curr Opin Gastroenterol 2012 Nov;28(6):621-8. doi: 10.1097/MOG.0b013e328358d619. PMID: 23041675

Intestinal neuronal dysplasia.

Puri P, Wester T
Semin Pediatr Surg 1998 Aug;7(3):181-6. doi: 10.1016/s1055-8586(98)70015-0. PMID: 9718657

Hirschprung's disease.

Sullivan PB
Arch Dis Child 1996 Jan;74(1):5-7. doi: 10.1136/adc.74.1.5. PMID: 8660047 Free PMC Article

See all (109)

Therapy

Transmissible α-synuclein seeding activity in brain and stomach of patients with Parkinson's disease.

Thomzig A, Wagenführ K, Pinder P, Joncic M, Schulz-Schaeffer WJ, Beekes M
Acta Neuropathol 2021 Jun;141(6):861-879. Epub 2021 Apr 24 doi: 10.1007/s00401-021-02312-4. PMID: 33895878 Free PMC Article

Effects of Serotonin and Slow-Release 5-Hydroxytryptophan on Gastrointestinal Motility in a Mouse Model of Depression.

Depletion of the IKBKAP ortholog in zebrafish leads to hirschsprung disease-like phenotype.

Cheng WW, Tang CS, Gui HS, So MT, Lui VC, Tam PK, Garcia-Barcelo MM
World J Gastroenterol 2015 Feb 21;21(7):2040-6. doi: 10.3748/wjg.v21.i7.2040. PMID: 25717236 Free PMC Article

Gastroparesis.

Hasler WL
Curr Opin Gastroenterol 2012 Nov;28(6):621-8. doi: 10.1097/MOG.0b013e328358d619. PMID: 23041675

Disturbed development of the enteric nervous system after in utero exposure of selective serotonin re-uptake inhibitors and tricyclic antidepressants. Part 1: Literature review.

Nijenhuis CM, Horst PG, Berg LT, Wilffert B
Br J Clin Pharmacol 2012 Jan;73(1):16-26. doi: 10.1111/j.1365-2125.2011.04075.x. PMID: 21815911 Free PMC Article

See all (13)

Prognosis

Simple rules for a "simple" nervous system? Molecular and biomathematical approaches to enteric nervous system formation and malformation.

Newgreen DF, Dufour S, Howard MJ, Landman KA
Dev Biol 2013 Oct 1;382(1):305-19. Epub 2013 Jul 6 doi: 10.1016/j.ydbio.2013.06.029. PMID: 23838398 Free PMC Article

Neurogenic bowel dysfunction in patients with spinal cord injury, myelomeningocele, multiple sclerosis and Parkinson's disease.

Awad RA
World J Gastroenterol 2011 Dec 14;17(46):5035-48. doi: 10.3748/wjg.v17.i46.5035. PMID: 22171138 Free PMC Article

Mathematical and experimental insights into the development of the enteric nervous system and Hirschsprung's disease.

Landman KA, Simpson MJ, Newgreen DF
Dev Growth Differ 2007 May;49(4):277-86. doi: 10.1111/j.1440-169X.2007.00929.x. PMID: 17501905

Variant Hirschsprung's disease.

Puri P, Rolle U
Semin Pediatr Surg 2004 Nov;13(4):293-9. doi: 10.1053/j.sempedsurg.2004.10.017. PMID: 15660323

Neuronal intestinal dysplasia.

Ryan DP
Semin Pediatr Surg 1995 Feb;4(1):22-5. PMID: 7728504

See all (40)

Clinical prediction guides

Enteric Nervous System Striped Patterning and Disease: Unexplored Pathophysiology.

Dershowitz LB, Kaltschmidt JA
Cell Mol Gastroenterol Hepatol 2024;18(2):101332. Epub 2024 Mar 11 doi: 10.1016/j.jcmgh.2024.03.004. PMID: 38479486 Free PMC Article

PTEN Immunohistochemistry.

Terra SA, de Arruda Lourenção PLT, Rodrigues MAM
Arch Pathol Lab Med 2022 May 1;147(5):577-583. doi: 10.5858/arpa.2021-0424-OA. PMID: 35943858

Glial Cell-Derived Neurotrophic Factor Induces Enteric Neurogenesis and Improves Colon Structure and Function in Mouse Models of Hirschsprung Disease.

Soret R, Schneider S, Bernas G, Christophers B, Souchkova O, Charrier B, Righini-Grunder F, Aspirot A, Landry M, Kembel SW, Faure C, Heuckeroth RO, Pilon N
Gastroenterology 2020 Nov;159(5):1824-1838.e17. Epub 2020 Jul 17 doi: 10.1053/j.gastro.2020.07.018. PMID: 32687927

Agmatine as a potential therapeutic intervention in bipolar depression: the preclinical landscape.

Watts D, Pfaffenseller B, Wollenhaupt-Aguiar B, Paul Géa L, Cardoso TA, Kapczinski F
Expert Opin Ther Targets 2019 Apr;23(4):327-339. Epub 2019 Feb 22 doi: 10.1080/14728222.2019.1581764. PMID: 30764678

Genetic interactions and modifier genes in Hirschsprung's disease.

Wallace AS, Anderson RB
World J Gastroenterol 2011 Dec 7;17(45):4937-44. doi: 10.3748/wjg.v17.i45.4937. PMID: 22174542 Free PMC Article

See all (99)

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Abnormal enteric neuron morphology

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

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