U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Abnormal adiponectin level

MedGen UID:
892755
•Concept ID:
C4073126
•
Finding
HPO: HP:0030684

Definition

A deviation from the normal circulating concentration of adiponectin, a 30-kDa complement C1-related protein that is the most abundant secreted protein expressed in adipose tissue, and that plays a crucial role in the regulation of insulin sensitivity and glucose metabolism. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal adiponectin level

Professional guidelines

PubMed

Predictors of Response to Ketamine in Treatment Resistant Major Depressive Disorder and Bipolar Disorder.
Rong C, Park C, Rosenblat JD, Subramaniapillai M, Zuckerman H, Fus D, Lee YL, Pan Z, Brietzke E, Mansur RB, Cha DS, Lui LMW, McIntyre RS
Int J Environ Res Public Health 2018 Apr 17;15(4) doi: 10.3390/ijerph15040771. PMID: 29673146Free PMC Article
An International Consortium Update: Pathophysiology, Diagnosis, and Treatment of Polycystic Ovarian Syndrome in Adolescence.
Ibáñez L, Oberfield SE, Witchel S, Auchus RJ, Chang RJ, Codner E, Dabadghao P, Darendeliler F, Elbarbary NS, Gambineri A, Garcia Rudaz C, Hoeger KM, López-Bermejo A, Ong K, Peña AS, Reinehr T, Santoro N, Tena-Sempere M, Tao R, Yildiz BO, Alkhayyat H, Deeb A, Joel D, Horikawa R, de Zegher F, Lee PA
Horm Res Paediatr 2017;88(6):371-395. Epub 2017 Nov 13 doi: 10.1159/000479371. PMID: 29156452
Adipose tissue dysfunction and hypertriglyceridemia: mechanisms and management.
van de Woestijne AP, Monajemi H, Kalkhoven E, Visseren FL
Obes Rev 2011 Oct;12(10):829-40. Epub 2011 Jul 12 doi: 10.1111/j.1467-789X.2011.00900.x. PMID: 21749607

Recent clinical studies

Etiology

Adiponectin blood levels and autism spectrum disorders: a systematic review.
Ali M, Kamran M, Talha M, Shad MU
BMC Psychiatry 2024 Jan 31;24(1):88. doi: 10.1186/s12888-024-05529-1. PMID: 38297246Free PMC Article
Pigment Epithelium-Derived Factor, a Novel Adipokine, Contributes to Gestational Diabetes Mellitus.
Qi W, Zhu D, Yin P, Gu X, Zhao Z, Li M, Dong C, Tang Q, Xie W, Zhou T, Xia H, Qiu X, Yang X, Gao G
J Clin Endocrinol Metab 2023 Dec 21;109(1):e356-e369. doi: 10.1210/clinem/dgad413. PMID: 37440564
Adiponectin in anorexia nervosa and its modifiers: A meta-regression study.
Tural U, Iosifescu DV
Int J Eat Disord 2022 Oct;55(10):1279-1290. Epub 2022 Jun 11 doi: 10.1002/eat.23753. PMID: 35689560
Adiponectin as Link Factor between Adipose Tissue and Cancer.
Di Zazzo E, Polito R, Bartollino S, Nigro E, Porcile C, Bianco A, Daniele A, Moncharmont B
Int J Mol Sci 2019 Feb 15;20(4) doi: 10.3390/ijms20040839. PMID: 30781341Free PMC Article
Obesity and gastric cancer.
Li Q, Zhang J, Zhou Y, Qiao L
Front Biosci (Landmark Ed) 2012 Jun 1;17(7):2383-90. doi: 10.2741/4059. PMID: 22652786

Diagnosis

Pulmonary hypertension and insulin resistance: a mechanistic overview.
Zanotto TM, Gonçalves AESS, Saad MJA
Front Endocrinol (Lausanne) 2023;14:1283233. Epub 2024 Jan 4 doi: 10.3389/fendo.2023.1283233. PMID: 38239990Free PMC Article
Pigment Epithelium-Derived Factor, a Novel Adipokine, Contributes to Gestational Diabetes Mellitus.
Qi W, Zhu D, Yin P, Gu X, Zhao Z, Li M, Dong C, Tang Q, Xie W, Zhou T, Xia H, Qiu X, Yang X, Gao G
J Clin Endocrinol Metab 2023 Dec 21;109(1):e356-e369. doi: 10.1210/clinem/dgad413. PMID: 37440564
Do patients with Prader-Willi syndrome have favorable glucose metabolism?
Qian Y, Xia F, Zuo Y, Zhong M, Yang L, Jiang Y, Zou C
Orphanet J Rare Dis 2022 May 7;17(1):187. doi: 10.1186/s13023-022-02344-3. PMID: 35525976Free PMC Article
The Role of the Adipokines in the Most Common Gestational Complications.
Gutaj P, Sibiak R, Jankowski M, Awdi K, Bryl R, Mozdziak P, Kempisty B, Wender-Ozegowska E
Int J Mol Sci 2020 Dec 10;21(24) doi: 10.3390/ijms21249408. PMID: 33321877Free PMC Article
An International Consortium Update: Pathophysiology, Diagnosis, and Treatment of Polycystic Ovarian Syndrome in Adolescence.
Ibáñez L, Oberfield SE, Witchel S, Auchus RJ, Chang RJ, Codner E, Dabadghao P, Darendeliler F, Elbarbary NS, Gambineri A, Garcia Rudaz C, Hoeger KM, López-Bermejo A, Ong K, Peña AS, Reinehr T, Santoro N, Tena-Sempere M, Tao R, Yildiz BO, Alkhayyat H, Deeb A, Joel D, Horikawa R, de Zegher F, Lee PA
Horm Res Paediatr 2017;88(6):371-395. Epub 2017 Nov 13 doi: 10.1159/000479371. PMID: 29156452

Therapy

Adiponectin in anorexia nervosa and its modifiers: A meta-regression study.
Tural U, Iosifescu DV
Int J Eat Disord 2022 Oct;55(10):1279-1290. Epub 2022 Jun 11 doi: 10.1002/eat.23753. PMID: 35689560
A New Perspective on Fish Oil: The Prevention of Alcoholic Liver Disease.
Yang SC
J Oleo Sci 2021;70(11):1531-1538. doi: 10.5650/jos.ess21216. PMID: 34732632
Second-generation antipsychotics and adiponectin levels in schizophrenia: A comparative meta-analysis.
Bartoli F, Crocamo C, Clerici M, Carrà G
Eur Neuropsychopharmacol 2015 Oct;25(10):1767-74. Epub 2015 Jun 20 doi: 10.1016/j.euroneuro.2015.06.011. PMID: 26164075
Plasma adiponectin levels in schizophrenia and role of second-generation antipsychotics: a meta-analysis.
Bartoli F, Lax A, Crocamo C, Clerici M, Carrà G
Psychoneuroendocrinology 2015 Jun;56:179-89. Epub 2015 Mar 14 doi: 10.1016/j.psyneuen.2015.03.012. PMID: 25827962
Cardiovascular manifestations of insulin resistance.
Chahwala V, Arora R
Am J Ther 2009 Sep-Oct;16(5):e14-28. doi: 10.1097/MJT.0b013e3180a724b3. PMID: 19114874

Prognosis

Adiponectin blood levels and autism spectrum disorders: a systematic review.
Ali M, Kamran M, Talha M, Shad MU
BMC Psychiatry 2024 Jan 31;24(1):88. doi: 10.1186/s12888-024-05529-1. PMID: 38297246Free PMC Article
Significance of Plasma Irisin, Adiponectin, and Retinol Binding Protein-4 Levels as Biomarkers for Obstructive Sleep Apnea Syndrome Severity.
Fazlıoğlu N, Uysal P, Durmus S, Yurt S, Gelisgen R, Uzun H
Biomolecules 2023 Sep 24;13(10) doi: 10.3390/biom13101440. PMID: 37892122Free PMC Article
Pigment Epithelium-Derived Factor, a Novel Adipokine, Contributes to Gestational Diabetes Mellitus.
Qi W, Zhu D, Yin P, Gu X, Zhao Z, Li M, Dong C, Tang Q, Xie W, Zhou T, Xia H, Qiu X, Yang X, Gao G
J Clin Endocrinol Metab 2023 Dec 21;109(1):e356-e369. doi: 10.1210/clinem/dgad413. PMID: 37440564
The Role of the Adipokines in the Most Common Gestational Complications.
Gutaj P, Sibiak R, Jankowski M, Awdi K, Bryl R, Mozdziak P, Kempisty B, Wender-Ozegowska E
Int J Mol Sci 2020 Dec 10;21(24) doi: 10.3390/ijms21249408. PMID: 33321877Free PMC Article
The role of adiponectin in placentation and preeclampsia.
Adu-Gyamfi EA, Fondjo LA, Owiredu WKBA, Czika A, Nelson W, Lamptey J, Wang YX, Ding YB
Cell Biochem Funct 2020 Jan;38(1):106-117. Epub 2019 Nov 19 doi: 10.1002/cbf.3458. PMID: 31746004

Clinical prediction guides

Adiponectin blood levels and autism spectrum disorders: a systematic review.
Ali M, Kamran M, Talha M, Shad MU
BMC Psychiatry 2024 Jan 31;24(1):88. doi: 10.1186/s12888-024-05529-1. PMID: 38297246Free PMC Article
Pigment Epithelium-Derived Factor, a Novel Adipokine, Contributes to Gestational Diabetes Mellitus.
Qi W, Zhu D, Yin P, Gu X, Zhao Z, Li M, Dong C, Tang Q, Xie W, Zhou T, Xia H, Qiu X, Yang X, Gao G
J Clin Endocrinol Metab 2023 Dec 21;109(1):e356-e369. doi: 10.1210/clinem/dgad413. PMID: 37440564
Do patients with Prader-Willi syndrome have favorable glucose metabolism?
Qian Y, Xia F, Zuo Y, Zhong M, Yang L, Jiang Y, Zou C
Orphanet J Rare Dis 2022 May 7;17(1):187. doi: 10.1186/s13023-022-02344-3. PMID: 35525976Free PMC Article
The Role of the Adipokines in the Most Common Gestational Complications.
Gutaj P, Sibiak R, Jankowski M, Awdi K, Bryl R, Mozdziak P, Kempisty B, Wender-Ozegowska E
Int J Mol Sci 2020 Dec 10;21(24) doi: 10.3390/ijms21249408. PMID: 33321877Free PMC Article
Adipose tissue dysfunction in nascent metabolic syndrome.
Bremer AA, Jialal I
J Obes 2013;2013:393192. Epub 2013 Apr 4 doi: 10.1155/2013/393192. PMID: 23653857Free PMC Article

Recent systematic reviews

Adiponectin blood levels and autism spectrum disorders: a systematic review.
Ali M, Kamran M, Talha M, Shad MU
BMC Psychiatry 2024 Jan 31;24(1):88. doi: 10.1186/s12888-024-05529-1. PMID: 38297246Free PMC Article
Circulating adiponectin as a biomarker in renal cell carcinoma: a systematic review and meta-analysis.
Yap NY, Yap FN, Perumal K, Rajandram R
Biomarkers 2019 Sep;24(6):607-614. Epub 2019 Jul 2 doi: 10.1080/1354750X.2019.1634763. PMID: 31215811
Systematic Review and Meta-Analysis of Randomized, Controlled Trials on the Effect of Exercise on Serum Leptin and Adiponectin in Overweight and Obese Individuals.
Yu N, Ruan Y, Gao X, Sun J
Horm Metab Res 2017 Mar;49(3):164-173. Epub 2017 Mar 1 doi: 10.1055/s-0042-121605. PMID: 28249299
Second-generation antipsychotics and adiponectin levels in schizophrenia: A comparative meta-analysis.
Bartoli F, Crocamo C, Clerici M, Carrà G
Eur Neuropsychopharmacol 2015 Oct;25(10):1767-74. Epub 2015 Jun 20 doi: 10.1016/j.euroneuro.2015.06.011. PMID: 26164075
Plasma adiponectin levels in schizophrenia and role of second-generation antipsychotics: a meta-analysis.
Bartoli F, Lax A, Crocamo C, Clerici M, Carrà G
Psychoneuroendocrinology 2015 Jun;56:179-89. Epub 2015 Mar 14 doi: 10.1016/j.psyneuen.2015.03.012. PMID: 25827962

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...