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Abnormality of cranial sutures

MedGen UID:: 868996
•Concept ID:: C4023412
•: Anatomical Abnormality

Synonyms:	Abnormality of the bregma sutures; Abnormality of the calvarium sutures; Abnormality of the cranial sutures; Abnormality of the skull suture

HPO:	HP:0011329

Definition

Any anomaly of a cranial suture, that is one of the six membrane-covered openings in the incompletely ossified skull of the fetus or newborn infant. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVAbnormality of cranial sutures

Abnormality of the musculoskeletal system
- Abnormality of the skeletal system
  - Abnormal skeletal morphology
    - Abnormal axial skeleton morphology
      - Abnormal skull morphology
        Abnormal cranial suture/fontanelle morphology
        Abnormality of cranial sutures
        Abnormality of the metopic suture
        Metopic depression
        Metopic suture patent to nasal root
        Metopic synostosis
        Prominent metopic ridge
        Accessory cranial suture
        Craniosynostosis syndrome
        Acrocephalosyndactyly
        Acrocephalosyndactyly type I
        Carpenter syndrome
        Pfeiffer syndrome
        Saethre-Chotzen syndrome
        Coronal craniosynostosis
        Bicoronal synostosis
        Unicoronal synostosis
        Craniosynostosis 2
        Craniosynostosis 4
        Bilambdoid synostosis
        Unilambdoid synostosis
        Multiple suture craniosynostosis
        Pansynostosis
        Sagittal craniosynostosis
        Squamosal suture synostosis
        TCF12-related craniosynostosis
        TWIST1-related craniosynostosis
        Beare-Stevenson cutis gyrata syndrome
        Crouzon syndrome
        Crouzon syndrome-acanthosis nigricans syndrome
        Isolated coronal synostosis
        Jackson-Weiss syndrome
        Muenke syndrome
        Delayed cranial suture closure
        Delayed closure of the anterior fontanelle
        Persistent open anterior fontanelle
        Ridged cranial sutures
        Sclerotic cranial sutures
        Wide cranial sutures
        Widely patent fontanelles and sutures
        Widely patent coronal suture
        Widely patent sagittal suture
        Wormian bones

Professional guidelines

PubMed

The clinical manifestations, molecular mechanisms and treatment of craniosynostosis.

Stanton E, Urata M, Chen JF, Chai Y
Dis Model Mech 2022 Apr 1;15(4) Epub 2022 Apr 22 doi: 10.1242/dmm.049390. PMID: 35451466 Free PMC Article

Craniosynostosis: Clinical Presentation, Genetics, and Prenatal Diagnosis.

Brah TK, Thind R, Abel DE
Obstet Gynecol Surv 2020 Oct;75(10):636-644. doi: 10.1097/OGX.0000000000000830. PMID: 33111964

Craniosynostosis - Recognition, clinical characteristics, and treatment.

Kajdic N, Spazzapan P, Velnar T
Bosn J Basic Med Sci 2018 May 20;18(2):110-116. doi: 10.17305/bjbms.2017.2083. PMID: 28623672 Free PMC Article

See all (43)

Recent clinical studies

Etiology

Craniosynostosis and hypophosphatasia.

Di Rocco F, Baujat G, Cormier-Daire V, Rothenbuhler A, Linglart A
Arch Pediatr 2017 May;24(5S2):5S89-5S92. doi: 10.1016/S0929-693X(18)30022-8. PMID: 29405940

Positional Skull Deformities.

Linz C, Kunz F, Böhm H, Schweitzer T
Dtsch Arztebl Int 2017 Aug 7;114(31-32):535-542. doi: 10.3238/arztebl.2017.0535. PMID: 28835328 Free PMC Article

Craniosynostosis.

Governale LS
Pediatr Neurol 2015 Nov;53(5):394-401. Epub 2015 Jul 22 doi: 10.1016/j.pediatrneurol.2015.07.006. PMID: 26371995

Posterior plagiocephaly.

Kalra R, Walker ML
Childs Nerv Syst 2012 Sep;28(9):1389-93. Epub 2012 Aug 8 doi: 10.1007/s00381-012-1784-y. PMID: 22872253

Craniosynostosis.

Johnson D, Wilkie AO
Eur J Hum Genet 2011 Apr;19(4):369-76. Epub 2011 Jan 19 doi: 10.1038/ejhg.2010.235. PMID: 21248745 Free PMC Article

See all (591)

Diagnosis

Craniosynostosis - Recognition, clinical characteristics, and treatment.

Kajdic N, Spazzapan P, Velnar T
Bosn J Basic Med Sci 2018 May 20;18(2):110-116. doi: 10.17305/bjbms.2017.2083. PMID: 28623672 Free PMC Article

Positional Skull Deformities.

Linz C, Kunz F, Böhm H, Schweitzer T
Dtsch Arztebl Int 2017 Aug 7;114(31-32):535-542. doi: 10.3238/arztebl.2017.0535. PMID: 28835328 Free PMC Article

Craniosynostosis.

Governale LS
Pediatr Neurol 2015 Nov;53(5):394-401. Epub 2015 Jul 22 doi: 10.1016/j.pediatrneurol.2015.07.006. PMID: 26371995

Craniofacial anomalies.

Nagy L, Demke JC
Facial Plast Surg Clin North Am 2014 Nov;22(4):523-48. Epub 2014 Nov 8 doi: 10.1016/j.fsc.2014.08.002. PMID: 25444726

Craniofacial syndromes.

Buchanan EP, Xue AS, Hollier LH Jr
Plast Reconstr Surg 2014 Jul;134(1):128e-153e. doi: 10.1097/PRS.0000000000000308. PMID: 25028828

See all (515)

Therapy

Craniosynostosis: A Reversible Pathology?

Säljö K, Maltese G, Tarnow P, Kölby L
J Craniofac Surg 2019 Sep;30(6):1628-1630. doi: 10.1097/SCS.0000000000005515. PMID: 31022145

Syndromic Craniosynostosis.

Sawh-Martinez R, Steinbacher DM
Clin Plast Surg 2019 Apr;46(2):141-155. doi: 10.1016/j.cps.2018.11.009. PMID: 30851747

Nonsyndromic Craniosynostosis.

Dempsey RF, Monson LA, Maricevich RS, Truong TA, Olarunnipa S, Lam SK, Dauser RC, Hollier LH Jr, Buchanan EP
Clin Plast Surg 2019 Apr;46(2):123-139. Epub 2019 Jan 30 doi: 10.1016/j.cps.2018.11.001. PMID: 30851746

Pycnodysostosis at otorhinolaryngology.

Baglam T, Binnetoglu A, Fatih Topuz M, Baş Ikizoglu N, Ersu R, Turan S, Sarı M
Int J Pediatr Otorhinolaryngol 2017 Apr;95:91-96. Epub 2017 Feb 11 doi: 10.1016/j.ijporl.2017.02.009. PMID: 28576543

Management of cranial deformity following ventricular shunting.

Doorenbosch X, Molloy CJ, David DJ, Santoreneos S, Anderson PJ
Childs Nerv Syst 2009 Jul;25(7):871-4. Epub 2009 Feb 27 doi: 10.1007/s00381-009-0842-6. PMID: 19247672

See all (114)

Prognosis

Subarachnomegaly-venous congestion of infancy.

Sainz LV, Schuhmann MU
Childs Nerv Syst 2021 Nov;37(11):3455-3463. Epub 2021 Oct 23 doi: 10.1007/s00381-021-05328-z. PMID: 34687332 Free PMC Article

Nonsyndromic Craniosynostosis.

A Genetic-Pathophysiological Framework for Craniosynostosis.

Twigg SR, Wilkie AO
Am J Hum Genet 2015 Sep 3;97(3):359-77. doi: 10.1016/j.ajhg.2015.07.006. PMID: 26340332 Free PMC Article

Complex craniosynostosis.

Czerwinski M, Kolar JC, Fearon JA
Plast Reconstr Surg 2011 Oct;128(4):955-961. doi: 10.1097/PRS.0b013e3182268ca6. PMID: 21681124

Carpenter syndrome.

Hidestrand P, Vasconez H, Cottrill C
J Craniofac Surg 2009 Jan;20(1):254-6. doi: 10.1097/SCS.0b013e318184357a. PMID: 19165041

See all (319)

Clinical prediction guides

Cranial sutures.

Ganz JC
Prog Brain Res 2024;285:127-136. Epub 2024 Apr 25 doi: 10.1016/bs.pbr.2024.02.019. PMID: 38705712

Molecular Mechanisms Involved in Craniosynostosis.

Yapijakis C, Pachis N, Sotiriadou T, Vaila C, Michopoulou V, Vassiliou S
In Vivo 2023 Jan-Feb;37(1):36-46. doi: 10.21873/invivo.13052. PMID: 36593018 Free PMC Article

The foramen magnum in scaphocephaly.

Skadorwa T, Wierzbieniec O
Childs Nerv Syst 2022 Nov;38(11):2163-2170. Epub 2022 Aug 5 doi: 10.1007/s00381-022-05624-2. PMID: 35931858 Free PMC Article

Nonsyndromic Craniosynostosis.

Pycnodysostosis at otorhinolaryngology.

Baglam T, Binnetoglu A, Fatih Topuz M, Baş Ikizoglu N, Ersu R, Turan S, Sarı M
Int J Pediatr Otorhinolaryngol 2017 Apr;95:91-96. Epub 2017 Feb 11 doi: 10.1016/j.ijporl.2017.02.009. PMID: 28576543

See all (327)

Recent systematic reviews

Management of Lambdoid Craniosynostosis: A Comprehensive and Systematic Review.

Reardon T, Fiani B, Kosarchuk J, Parisi A, Shlobin NA
Pediatr Neurosurg 2022;57(1):1-16. Epub 2021 Dec 3 doi: 10.1159/000519175. PMID: 34864743

Postnatal diagnosis of single-suture craniosynostosis with cranial ultrasound: a systematic review.

Whittall I, Lambert WA, Moote DJ, Bookland MJ, Martin JE, Hughes CD, Hersh DS
Childs Nerv Syst 2021 Dec;37(12):3705-3714. Epub 2021 Oct 5 doi: 10.1007/s00381-021-05301-w. PMID: 34611761

Sutures ultrasound: useful diagnostic screening for posterior plagiocephaly.

Marino S, Ruggieri M, Marino L, Falsaperla R
Childs Nerv Syst 2021 Dec;37(12):3715-3720. Epub 2021 Aug 28 doi: 10.1007/s00381-021-05324-3. PMID: 34453581 Free PMC Article

The State of Technology in Craniosynostosis.

Safran T, Viezel-Mathieu A, Beland B, Azzi AJ, Galli R, Gilardino M
J Craniofac Surg 2018 Jun;29(4):904-907. doi: 10.1097/SCS.0000000000004399. PMID: 29498975

Determining the fate of cranial sutures after surgical correction of non-syndromic craniosynostosis.

Kim SY, Shin HJ, Lim SY
J Craniomaxillofac Surg 2017 Nov;45(11):1801-1808. Epub 2017 Aug 19 doi: 10.1016/j.jcms.2017.08.009. PMID: 28939204

See all (17)

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Abnormality of cranial sutures

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

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