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Intracranial epidermoid cyst

MedGen UID:
868644
•Concept ID:
C4023045
•
Anatomical Abnormality
HPO: HP:0012096

Definition

A congenital inclusion cysts that arises from ectodermal cells that normally form skin cells being left behind in the nervous system during development. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIntracranial epidermoid cyst

Professional guidelines

PubMed

Survival outcomes for radiotherapy treatment of epidermoid tumors with malignant transformation.
Nagasawa D, Yew A, Spasic M, Choy W, Gopen Q, Yang I
J Clin Neurosci 2012 Jan;19(1):21-6. Epub 2011 Oct 22 doi: 10.1016/j.jocn.2011.06.002. PMID: 22024232
Differential diagnosis of intracranial lesions with high signal on T1 or low signal on T2-weighted MRI.
Warakaulle DR, Anslow P
Clin Radiol 2003 Dec;58(12):922-33. doi: 10.1016/s0009-9260(03)00268-x. PMID: 14654024
Surgical management of tumours of the pineal region.
Obrador S, Soto M, Gutierrez-Diaz JA
Acta Neurochir (Wien) 1976;34(1-4):159-71. doi: 10.1007/BF01405870. PMID: 961477

Recent clinical studies

Etiology

Intracranial Epidermoid Cyst: A Volumetric Study of a Surgically Challenging Benign Lesion.
Kiss-Bodolay D, Hautmann X, Lee KS, Rohde V, Schaller K
World Neurosurg 2024 May;185:e1129-e1135. Epub 2024 Mar 15 doi: 10.1016/j.wneu.2024.03.035. PMID: 38493891
Intracranial Dermoid in Patients With Fibrous Dysplasia.
Song X, Li Z
J Craniofac Surg 2023 Jul-Aug 01;34(5):e415-e419. Epub 2023 Jan 23 doi: 10.1097/SCS.0000000000009166. PMID: 36727926
Combined Endoscopic and Exoscopic Resection of Intracranial Epidermoid Cysts.
Li Z, Gui S, Zhao P, Bai J, Cao L, Cheng S, Liu C, Zhu H, Zhang Y, Li C
World Neurosurg 2022 Dec;168:e28-e33. Epub 2022 Aug 31 doi: 10.1016/j.wneu.2022.08.111. PMID: 36055616
The implication of tumor biomarker CA19-9 in the diagnosis of intracranial epidermoid cyst.
Wang Y, Yan W, Wu Q, Chen G, Zhang J
Oncotarget 2017 Jan 10;8(2):2164-2170. doi: 10.18632/oncotarget.12934. PMID: 27793056Free PMC Article
Spontaneous regression of an epidermoid cyst of the cavernous sinus.
Yanamadala V, Lin N, Walcott BP, Baird LC, Smith ER
J Clin Neurosci 2014 Aug;21(8):1433-5. Epub 2014 Apr 13 doi: 10.1016/j.jocn.2013.11.054. PMID: 24736191

Diagnosis

Intracranial Epidermoid Cyst: A Volumetric Study of a Surgically Challenging Benign Lesion.
Kiss-Bodolay D, Hautmann X, Lee KS, Rohde V, Schaller K
World Neurosurg 2024 May;185:e1129-e1135. Epub 2024 Mar 15 doi: 10.1016/j.wneu.2024.03.035. PMID: 38493891
Intracranial Dermoid in Patients With Fibrous Dysplasia.
Song X, Li Z
J Craniofac Surg 2023 Jul-Aug 01;34(5):e415-e419. Epub 2023 Jan 23 doi: 10.1097/SCS.0000000000009166. PMID: 36727926
The implication of tumor biomarker CA19-9 in the diagnosis of intracranial epidermoid cyst.
Wang Y, Yan W, Wu Q, Chen G, Zhang J
Oncotarget 2017 Jan 10;8(2):2164-2170. doi: 10.18632/oncotarget.12934. PMID: 27793056Free PMC Article
Malignant transformation of a residual cerebellopontine angle epidermoid cyst.
Pikis S, Margolin E
J Clin Neurosci 2016 Nov;33:59-62. Epub 2016 Aug 9 doi: 10.1016/j.jocn.2016.04.008. PMID: 27519146
Malignant transformation of intracranial epidermoid cyst.
Vellutini EA, de Oliveira MF, Ribeiro AP, Rotta JM
Br J Neurosurg 2014 Aug;28(4):507-9. Epub 2013 Dec 18 doi: 10.3109/02688697.2013.869552. PMID: 24345076

Therapy

Long-term evaluation of asymptomatic patients operated on for intracranial epidermoid cysts. Comparison of the diagnostic value of magnetic resonance imaging and computer-assisted cisternography for detection of cholesterin fragments.
Lunardi P, Fortuna A, Cantore G, Missori P
Acta Neurochir (Wien) 1994;128(1-4):122-5. doi: 10.1007/BF01400661. PMID: 7847127

Prognosis

Intracranial Epidermoid Cyst: A Volumetric Study of a Surgically Challenging Benign Lesion.
Kiss-Bodolay D, Hautmann X, Lee KS, Rohde V, Schaller K
World Neurosurg 2024 May;185:e1129-e1135. Epub 2024 Mar 15 doi: 10.1016/j.wneu.2024.03.035. PMID: 38493891
Combined Endoscopic and Exoscopic Resection of Intracranial Epidermoid Cysts.
Li Z, Gui S, Zhao P, Bai J, Cao L, Cheng S, Liu C, Zhu H, Zhang Y, Li C
World Neurosurg 2022 Dec;168:e28-e33. Epub 2022 Aug 31 doi: 10.1016/j.wneu.2022.08.111. PMID: 36055616
Infundibular Epidermoid Cyst: Case Report and Systematic Review.
Khan AB, Goethe EA, Hadley CC, Rouah E, North R, Srinivasan VM, Gallagher KK, Fuentes A, Vaz-Guimaraes F
World Neurosurg 2019 Oct;130:110-114. Epub 2019 Jul 5 doi: 10.1016/j.wneu.2019.06.205. PMID: 31284058
The implication of tumor biomarker CA19-9 in the diagnosis of intracranial epidermoid cyst.
Wang Y, Yan W, Wu Q, Chen G, Zhang J
Oncotarget 2017 Jan 10;8(2):2164-2170. doi: 10.18632/oncotarget.12934. PMID: 27793056Free PMC Article
Malignant transformation of an intracranial large epidermoid cyst with leptomeningeal carcinomatosis: case report.
Kano T, Ikota H, Kobayashi S, Iwasa S, Kurosaki S, Wada H
Neurol Med Chir (Tokyo) 2010;50(4):349-53. doi: 10.2176/nmc.50.349. PMID: 20448435

Clinical prediction guides

Intracranial Epidermoid Cyst: A Volumetric Study of a Surgically Challenging Benign Lesion.
Kiss-Bodolay D, Hautmann X, Lee KS, Rohde V, Schaller K
World Neurosurg 2024 May;185:e1129-e1135. Epub 2024 Mar 15 doi: 10.1016/j.wneu.2024.03.035. PMID: 38493891
Combined Endoscopic and Exoscopic Resection of Intracranial Epidermoid Cysts.
Li Z, Gui S, Zhao P, Bai J, Cao L, Cheng S, Liu C, Zhu H, Zhang Y, Li C
World Neurosurg 2022 Dec;168:e28-e33. Epub 2022 Aug 31 doi: 10.1016/j.wneu.2022.08.111. PMID: 36055616
Intracranial epidermoid cyst with proliferative folliculosebaceous epithelium: Report of a rare case and discussion on pathogenesis.
Okada T, Fujitsu K, Ichikawa T, Miyahara K, Tanino S, Uriu Y, Hataoka S, Tanaka Y, Suzuki K, Niino H, Yagishita S, Kato I
Neuropathology 2018 Oct;38(5):510-515. Epub 2018 Jun 6 doi: 10.1111/neup.12481. PMID: 29876981
The implication of tumor biomarker CA19-9 in the diagnosis of intracranial epidermoid cyst.
Wang Y, Yan W, Wu Q, Chen G, Zhang J
Oncotarget 2017 Jan 10;8(2):2164-2170. doi: 10.18632/oncotarget.12934. PMID: 27793056Free PMC Article
Malignant transformation of an intracranial large epidermoid cyst with leptomeningeal carcinomatosis: case report.
Kano T, Ikota H, Kobayashi S, Iwasa S, Kurosaki S, Wada H
Neurol Med Chir (Tokyo) 2010;50(4):349-53. doi: 10.2176/nmc.50.349. PMID: 20448435

Recent systematic reviews

Intracranial Dermoid in Patients With Fibrous Dysplasia.
Song X, Li Z
J Craniofac Surg 2023 Jul-Aug 01;34(5):e415-e419. Epub 2023 Jan 23 doi: 10.1097/SCS.0000000000009166. PMID: 36727926
Infundibular Epidermoid Cyst: Case Report and Systematic Review.
Khan AB, Goethe EA, Hadley CC, Rouah E, North R, Srinivasan VM, Gallagher KK, Fuentes A, Vaz-Guimaraes F
World Neurosurg 2019 Oct;130:110-114. Epub 2019 Jul 5 doi: 10.1016/j.wneu.2019.06.205. PMID: 31284058

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