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Abnormally slow thought process

MedGen UID:
640666
•Concept ID:
C0554976
•
Mental or Behavioral Dysfunction
Synonyms: Abnormally slow thought processes; Bradyphrenia; Mental slowness; Slow thought processes; Slowed thinking; Slowed thoughts; Slowness of thought
SNOMED CT: Bradyphrenia (285242009)
 
HPO: HP:0031843

Definition

An inner sense from the self that thoughts are abnormally slow and the individual feels that they are unable to increase their rate of thinking. The primary pathology is the decreased rate and other qualities of thinking (e.g. naming of objects) are intact, just slowed. This may be associated with slowed speech, but may be internal and masked by speech that is limited to brief (yes or no) answers. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormally slow thought process

Conditions with this feature

Intellectual disability, autosomal dominant 56
MedGen UID:
1638835
•Concept ID:
C4693389
•
Mental or Behavioral Dysfunction
See: Condition Record
Intellectual disability, autosomal dominant 56

Professional guidelines

PubMed

Expert consensus recommendations to improve diagnosis of ATTR amyloidosis with polyneuropathy.
Adams D, Ando Y, Beirão JM, Coelho T, Gertz MA, Gillmore JD, Hawkins PN, Lousada I, Suhr OB, Merlini G
J Neurol 2021 Jun;268(6):2109-2122. Epub 2020 Jan 6 doi: 10.1007/s00415-019-09688-0. PMID: 31907599Free PMC Article
Ageing and Down syndrome: Neurocognitive characteristics and pharmacological treatment.
Malegiannaki AC, Katsarou D, Liolios A, Zisi V
Hell J Nucl Med 2019 Jan-Apr;22 Suppl:123-132. PMID: 30877730
Bilateral vestibulopathy: Diagnostic criteria Consensus document of the Classification Committee of the Bárány Society.
Strupp M, Kim JS, Murofushi T, Straumann D, Jen JC, Rosengren SM, Della Santina CC, Kingma H
J Vestib Res 2017;27(4):177-189. doi: 10.3233/VES-170619. PMID: 29081426Free PMC Article

Recent clinical studies

Etiology

Rationale for a Multi-Factorial Approach for the Reversal of Cognitive Decline in Alzheimer's Disease and MCI: A Review.
Rao RV, Subramaniam KG, Gregory J, Bredesen AL, Coward C, Okada S, Kelly L, Bredesen DE
Int J Mol Sci 2023 Jan 14;24(2) doi: 10.3390/ijms24021659. PMID: 36675177Free PMC Article
Binocular summation revisited: Beyond √2.
Baker DH, Lygo FA, Meese TS, Georgeson MA
Psychol Bull 2018 Nov;144(11):1186-1199. Epub 2018 Aug 13 doi: 10.1037/bul0000163. PMID: 30102058Free PMC Article
Addiction as a BAD, a Behavioral Allocation Disorder.
Lamb RJ, Ginsburg BC
Pharmacol Biochem Behav 2018 Jan;164:62-70. Epub 2017 May 2 doi: 10.1016/j.pbb.2017.05.002. PMID: 28476485Free PMC Article
Cognition and gait in older people.
Cohen JA, Verghese J, Zwerling JL
Maturitas 2016 Nov;93:73-77. Epub 2016 May 10 doi: 10.1016/j.maturitas.2016.05.005. PMID: 27240713
Developmental precursors of psychosis.
Isohanni M, Isohanni I, Koponen H, Koskinen J, Laine P, Lauronen E, Miettunen J, Mäki P, Riala K, Räsänen S, Saari K, Tienari P, Veijola J, Murray G
Curr Psychiatry Rep 2004 Jun;6(3):168-75. doi: 10.1007/s11920-004-0061-5. PMID: 15142469

Diagnosis

Expert consensus recommendations to improve diagnosis of ATTR amyloidosis with polyneuropathy.
Adams D, Ando Y, Beirão JM, Coelho T, Gertz MA, Gillmore JD, Hawkins PN, Lousada I, Suhr OB, Merlini G
J Neurol 2021 Jun;268(6):2109-2122. Epub 2020 Jan 6 doi: 10.1007/s00415-019-09688-0. PMID: 31907599Free PMC Article
NREM sleep parasomnias as disorders of sleep-state dissociation.
Castelnovo A, Lopez R, Proserpio P, Nobili L, Dauvilliers Y
Nat Rev Neurol 2018 Aug;14(8):470-481. doi: 10.1038/s41582-018-0030-y. PMID: 29959394
Bilateral vestibulopathy: Diagnostic criteria Consensus document of the Classification Committee of the Bárány Society.
Strupp M, Kim JS, Murofushi T, Straumann D, Jen JC, Rosengren SM, Della Santina CC, Kingma H
J Vestib Res 2017;27(4):177-189. doi: 10.3233/VES-170619. PMID: 29081426Free PMC Article
Why not a slow code?
Forman EN, Ladd RE
Virtual Mentor 2012 Oct 1;14(10):759-62. doi: 10.1001/virtualmentor.2012.14.10.ecas1-1210. PMID: 23351851
Developmental precursors of psychosis.
Isohanni M, Isohanni I, Koponen H, Koskinen J, Laine P, Lauronen E, Miettunen J, Mäki P, Riala K, Räsänen S, Saari K, Tienari P, Veijola J, Murray G
Curr Psychiatry Rep 2004 Jun;6(3):168-75. doi: 10.1007/s11920-004-0061-5. PMID: 15142469

Therapy

Systemic therapies for salivary gland cancer: Adenoid cystic carcinoma. REFCOR recommendations by the formal consensus method.
Ferrand FR, Even C, Chabrillac E, Thariat J, Fakhry N, Vergez S, Bensadoun RJ, Sarradin V, Digue L
Eur Ann Otorhinolaryngol Head Neck Dis 2024 Sep;141(5):286-291. Epub 2023 Dec 6 doi: 10.1016/j.anorl.2023.11.009. PMID: 38061943
A Review on the Relationship between Tocotrienol and Alzheimer Disease.
Chin KY, Tay SS
Nutrients 2018 Jul 9;10(7) doi: 10.3390/nu10070881. PMID: 29987193Free PMC Article
Longitudinal hearing loss in Wolfram syndrome.
Karzon R, Narayanan A, Chen L, Lieu JEC, Hershey T
Orphanet J Rare Dis 2018 Jun 27;13(1):102. doi: 10.1186/s13023-018-0852-0. PMID: 29945639Free PMC Article
Early Communication Development of Children with Auditory Brainstem Implants.
Eisenberg LS, Hammes Ganguly D, Martinez AS, Fisher LM, Winter ME, Glater JL, Schrader DK, Loggins J, Wilkinson EP; Los Angeles Pediatric ABI Team
J Deaf Stud Deaf Educ 2018 Jul 1;23(3):249-260. doi: 10.1093/deafed/eny010. PMID: 29718280Free PMC Article
Developmental precursors of psychosis.
Isohanni M, Isohanni I, Koponen H, Koskinen J, Laine P, Lauronen E, Miettunen J, Mäki P, Riala K, Räsänen S, Saari K, Tienari P, Veijola J, Murray G
Curr Psychiatry Rep 2004 Jun;6(3):168-75. doi: 10.1007/s11920-004-0061-5. PMID: 15142469

Prognosis

Motoric cognitive risk syndrome: Integration of two early harbingers of dementia in older adults.
Semba RD, Tian Q, Carlson MC, Xue QL, Ferrucci L
Ageing Res Rev 2020 Mar;58:101022. Epub 2020 Jan 26 doi: 10.1016/j.arr.2020.101022. PMID: 31996326Free PMC Article
Gait Dysfunction in Motoric Cognitive Risk Syndrome.
Ayers E, Verghese J
J Alzheimers Dis 2019;71(s1):S95-S103. doi: 10.3233/JAD-181227. PMID: 30909242Free PMC Article
Binocular summation revisited: Beyond √2.
Baker DH, Lygo FA, Meese TS, Georgeson MA
Psychol Bull 2018 Nov;144(11):1186-1199. Epub 2018 Aug 13 doi: 10.1037/bul0000163. PMID: 30102058Free PMC Article
Cognition and gait in older people.
Cohen JA, Verghese J, Zwerling JL
Maturitas 2016 Nov;93:73-77. Epub 2016 May 10 doi: 10.1016/j.maturitas.2016.05.005. PMID: 27240713
Developmental precursors of psychosis.
Isohanni M, Isohanni I, Koponen H, Koskinen J, Laine P, Lauronen E, Miettunen J, Mäki P, Riala K, Räsänen S, Saari K, Tienari P, Veijola J, Murray G
Curr Psychiatry Rep 2004 Jun;6(3):168-75. doi: 10.1007/s11920-004-0061-5. PMID: 15142469

Clinical prediction guides

Rationale for a Multi-Factorial Approach for the Reversal of Cognitive Decline in Alzheimer's Disease and MCI: A Review.
Rao RV, Subramaniam KG, Gregory J, Bredesen AL, Coward C, Okada S, Kelly L, Bredesen DE
Int J Mol Sci 2023 Jan 14;24(2) doi: 10.3390/ijms24021659. PMID: 36675177Free PMC Article
Ageing and Down syndrome: Neurocognitive characteristics and pharmacological treatment.
Malegiannaki AC, Katsarou D, Liolios A, Zisi V
Hell J Nucl Med 2019 Jan-Apr;22 Suppl:123-132. PMID: 30877730
Binocular summation revisited: Beyond √2.
Baker DH, Lygo FA, Meese TS, Georgeson MA
Psychol Bull 2018 Nov;144(11):1186-1199. Epub 2018 Aug 13 doi: 10.1037/bul0000163. PMID: 30102058Free PMC Article
Cognition and gait in older people.
Cohen JA, Verghese J, Zwerling JL
Maturitas 2016 Nov;93:73-77. Epub 2016 May 10 doi: 10.1016/j.maturitas.2016.05.005. PMID: 27240713
Developmental precursors of psychosis.
Isohanni M, Isohanni I, Koponen H, Koskinen J, Laine P, Lauronen E, Miettunen J, Mäki P, Riala K, Räsänen S, Saari K, Tienari P, Veijola J, Murray G
Curr Psychiatry Rep 2004 Jun;6(3):168-75. doi: 10.1007/s11920-004-0061-5. PMID: 15142469

Recent systematic reviews

Rationale for a Multi-Factorial Approach for the Reversal of Cognitive Decline in Alzheimer's Disease and MCI: A Review.
Rao RV, Subramaniam KG, Gregory J, Bredesen AL, Coward C, Okada S, Kelly L, Bredesen DE
Int J Mol Sci 2023 Jan 14;24(2) doi: 10.3390/ijms24021659. PMID: 36675177Free PMC Article
Consensus clinical management guidelines for Alström syndrome.
Tahani N, Maffei P, Dollfus H, Paisey R, Valverde D, Milan G, Han JC, Favaretto F, Madathil SC, Dawson C, Armstrong MJ, Warfield AT, Düzenli S, Francomano CA, Gunay-Aygun M, Dassie F, Marion V, Valenti M, Leeson-Beevers K, Chivers A, Steeds R, Barrett T, Geberhiwot T
Orphanet J Rare Dis 2020 Sep 21;15(1):253. doi: 10.1186/s13023-020-01468-8. PMID: 32958032Free PMC Article
Motoric cognitive risk syndrome, incident cognitive impairment and morphological brain abnormalities: Systematic review and meta-analysis.
Sekhon H, Allali G, Launay CP, Barden J, Szturm T, Liu-Ambrose T, Chester VL, Wong CH, Beauchet O; Canadian Gait Consortium
Maturitas 2019 May;123:45-54. Epub 2019 Feb 18 doi: 10.1016/j.maturitas.2019.02.006. PMID: 31027677

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