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Specific language impairment 2(SLI2)

MedGen UID:
338273
•Concept ID:
C1847605
•
Disease or Syndrome
Synonyms: SLI2; SPECIFIC LANGUAGE IMPAIRMENT QUANTITATIVE TRAIT LOCUS ON CHROMOSOME 19
 
Monarch Initiative: MONDO:0011711
OMIM®: 606712

Definition

Specific language impairment (SLI) is diagnosed in children who exhibit significant language deficits despite adequate educational opportunity and normal nonverbal intelligence. SLI2 represents a locus influencing language-related traits on chromosome 19q (SLI Consortium, 2002, SLI Consortium, 2004). For a phenotypic description and a discussion of genetic heterogeneity of specific language impairment, see SLI1 (602081). [from OMIM]

Clinical features

From HPO
Language disorder
MedGen UID:
44069
•Concept ID:
C0023015
•
Mental or Behavioral Dysfunction
Language impairment is a deficit in comprehension or production of language that includes reduced vocabulary, limited sentence structure, or impairments in written or spoken communication. Language abilities are substantially and quantifiably below age expectations.
See: Feature record | Search on this feature
Expressive language delay
MedGen UID:
141568
•Concept ID:
C0454641
•
Disease or Syndrome
A delay in the acquisition of the ability to use language to communicate needs, wishes, or thoughts.
See: Feature record | Search on this feature
Deficit in phonologic short-term memory
MedGen UID:
339803
•Concept ID:
C1847609
•
Finding
Impaired ability to repeat non-word sounds. The test for nonword repetition involves the repetition of nonsensical words of increasing length and complexity and is regarded as a measure of phonological (speech sound) processing and short-term memory
See: Feature record | Search on this feature
Deficit in nonword repetition
MedGen UID:
871222
•Concept ID:
C4025702
•
Finding
Impaired ability to repeat non-word sounds. Nonword repetition (NWR) is a measure of short-term phonological memory.
See: Feature record | Search on this feature

Professional guidelines

PubMed

Myoclonus: Differential diagnosis and current management.
Riva A, D'Onofrio G, Ferlazzo E, Pascarella A, Pasini E, Franceschetti S, Panzica F, Canafoglia L, Vignoli A, Coppola A, Badioni V, Beccaria F, Labate A, Gambardella A, Romeo A, Capovilla G, Michelucci R, Striano P, Belcastro V
Epilepsia Open 2024 Apr;9(2):486-500. Epub 2024 Feb 9 doi: 10.1002/epi4.12917. PMID: 38334331Free PMC Article
Speech and language therapy approaches to managing primary progressive aphasia.
Volkmer A, Rogalski E, Henry M, Taylor-Rubin C, Ruggero L, Khayum R, Kindell J, Gorno-Tempini ML, Warren JD, Rohrer JD
Pract Neurol 2020 Apr;20(2):154-161. Epub 2019 Jul 29 doi: 10.1136/practneurol-2018-001921. PMID: 31358572Free PMC Article
An evidence-based clinical guideline for the diagnosis and treatment of lumbar disc herniation with radiculopathy.
Kreiner DS, Hwang SW, Easa JE, Resnick DK, Baisden JL, Bess S, Cho CH, DePalma MJ, Dougherty P 2nd, Fernand R, Ghiselli G, Hanna AS, Lamer T, Lisi AJ, Mazanec DJ, Meagher RJ, Nucci RC, Patel RD, Sembrano JN, Sharma AK, Summers JT, Taleghani CK, Tontz WL Jr, Toton JF; North American Spine Society
Spine J 2014 Jan;14(1):180-91. Epub 2013 Nov 14 doi: 10.1016/j.spinee.2013.08.003. PMID: 24239490

Recent clinical studies

Therapy

Autism Spectrum Disorder: A Review.
Hirota T, King BH
JAMA 2023 Jan 10;329(2):157-168. doi: 10.1001/jama.2022.23661. PMID: 36625807
Prevalence and Correlates of Suicide and Nonsuicidal Self-injury in Children: A Systematic Review and Meta-analysis.
Liu RT, Walsh RFL, Sheehan AE, Cheek SM, Sanzari CM
JAMA Psychiatry 2022 Jul 1;79(7):718-726. doi: 10.1001/jamapsychiatry.2022.1256. PMID: 35612875Free PMC Article
Association Between Physical Activity and Risk of Depression: A Systematic Review and Meta-analysis.
Pearce M, Garcia L, Abbas A, Strain T, Schuch FB, Golubic R, Kelly P, Khan S, Utukuri M, Laird Y, Mok A, Smith A, Tainio M, Brage S, Woodcock J
JAMA Psychiatry 2022 Jun 1;79(6):550-559. doi: 10.1001/jamapsychiatry.2022.0609. PMID: 35416941Free PMC Article
Diagnosing and managing post-stroke aphasia.
Sheppard SM, Sebastian R
Expert Rev Neurother 2021 Feb;21(2):221-234. Epub 2020 Dec 10 doi: 10.1080/14737175.2020.1855976. PMID: 33231117Free PMC Article
An evidence-based clinical guideline for the diagnosis and treatment of lumbar disc herniation with radiculopathy.
Kreiner DS, Hwang SW, Easa JE, Resnick DK, Baisden JL, Bess S, Cho CH, DePalma MJ, Dougherty P 2nd, Fernand R, Ghiselli G, Hanna AS, Lamer T, Lisi AJ, Mazanec DJ, Meagher RJ, Nucci RC, Patel RD, Sembrano JN, Sharma AK, Summers JT, Taleghani CK, Tontz WL Jr, Toton JF; North American Spine Society
Spine J 2014 Jan;14(1):180-91. Epub 2013 Nov 14 doi: 10.1016/j.spinee.2013.08.003. PMID: 24239490

Prognosis

New Australian guidelines for the treatment of alcohol problems: an overview of recommendations.
Haber PS, Riordan BC, Winter DT, Barrett L, Saunders J, Hides L, Gullo M, Manning V, Day CA, Bonomo Y, Burns L, Assan R, Curry K, Mooney-Somers J, Demirkol A, Monds L, McDonough M, Baillie AJ, Clark P, Ritter A, Quinn C, Cunningham J, Lintzeris N, Rombouts S, Savic M, Norman A, Reid S, Hutchinson D, Zheng C, Iese Y, Black N, Draper B, Ridley N, Gowing L, Stapinski L, Taye B, Lancaster K, Stjepanović D, Kay-Lambkin F, Jamshidi N, Lubman D, Pastor A, White N, Wilson S, Jaworski AL, Memedovic S, Logge W, Mills K, Seear K, Freeburn B, Lea T, Withall A, Marel C, Boffa J, Roxburgh A, Purcell-Khodr G, Doyle M, Conigrave K, Teesson M, Butler K, Connor J, Morley KC
Med J Aust 2021 Oct 4;215 Suppl 7:S3-S32. doi: 10.5694/mja2.51254. PMID: 34601742
Statistical Learning and Language Impairments: Toward More Precise Theoretical Accounts.
Bogaerts L, Siegelman N, Frost R
Perspect Psychol Sci 2021 Mar;16(2):319-337. Epub 2020 Nov 2 doi: 10.1177/1745691620953082. PMID: 33136519Free PMC Article
The Prevalence of Anxiety Disorders During Pregnancy and the Postpartum Period: A Multivariate Bayesian Meta-Analysis.
Fawcett EJ, Fairbrother N, Cox ML, White IR, Fawcett JM
J Clin Psychiatry 2019 Jul 23;80(4) doi: 10.4088/JCP.18r12527. PMID: 31347796Free PMC Article
Phase 2 of CATALISE: a multinational and multidisciplinary Delphi consensus study of problems with language development: Terminology.
Bishop DVM, Snowling MJ, Thompson PA, Greenhalgh T; and the CATALISE-2 consortium
J Child Psychol Psychiatry 2017 Oct;58(10):1068-1080. Epub 2017 Mar 30 doi: 10.1111/jcpp.12721. PMID: 28369935Free PMC Article
Mortality in mental disorders and global disease burden implications: a systematic review and meta-analysis.
Walker ER, McGee RE, Druss BG
JAMA Psychiatry 2015 Apr;72(4):334-41. doi: 10.1001/jamapsychiatry.2014.2502. PMID: 25671328Free PMC Article

Clinical prediction guides

Brain and Language Associations in Autism Spectrum Disorder: A Scoping Review.
Cermak CA, Arshinoff S, Ribeiro de Oliveira L, Tendera A, Beal DS, Brian J, Anagnostou E, Sanjeevan T
J Autism Dev Disord 2022 Feb;52(2):725-737. Epub 2021 Mar 25 doi: 10.1007/s10803-021-04975-0. PMID: 33765302
Pragmatic abilities in early Parkinson's disease.
Baraldi MA, Avanzino L, Pelosin E, Domaneschi F, Di Paola S, Lagravinese G
Brain Cogn 2021 Jun;150:105706. Epub 2021 Mar 21 doi: 10.1016/j.bandc.2021.105706. PMID: 33761383
Statistical Learning and Language Impairments: Toward More Precise Theoretical Accounts.
Bogaerts L, Siegelman N, Frost R
Perspect Psychol Sci 2021 Mar;16(2):319-337. Epub 2020 Nov 2 doi: 10.1177/1745691620953082. PMID: 33136519Free PMC Article
Early language delay and specific language impairment.
Moyle J, Stokes SF, Klee T
Dev Disabil Res Rev 2011;17(2):160-9. doi: 10.1002/ddrr.1110. PMID: 23362035
Childhood aphasias.
Martins IP
Clin Neurosci 1997;4(2):73-7. PMID: 9059756

Recent systematic reviews

Cognitive stimulation and cognitive results in older adults: A systematic review and meta-analysis.
Gómez-Soria I, Iguacel I, Aguilar-Latorre A, Peralta-Marrupe P, Latorre E, Zaldívar JNC, Calatayud E
Arch Gerontol Geriatr 2023 Jan;104:104807. Epub 2022 Sep 6 doi: 10.1016/j.archger.2022.104807. PMID: 36116285
Prevalence and Correlates of Suicide and Nonsuicidal Self-injury in Children: A Systematic Review and Meta-analysis.
Liu RT, Walsh RFL, Sheehan AE, Cheek SM, Sanzari CM
JAMA Psychiatry 2022 Jul 1;79(7):718-726. doi: 10.1001/jamapsychiatry.2022.1256. PMID: 35612875Free PMC Article
Association Between Physical Activity and Risk of Depression: A Systematic Review and Meta-analysis.
Pearce M, Garcia L, Abbas A, Strain T, Schuch FB, Golubic R, Kelly P, Khan S, Utukuri M, Laird Y, Mok A, Smith A, Tainio M, Brage S, Woodcock J
JAMA Psychiatry 2022 Jun 1;79(6):550-559. doi: 10.1001/jamapsychiatry.2022.0609. PMID: 35416941Free PMC Article
Mortality in mental disorders and global disease burden implications: a systematic review and meta-analysis.
Walker ER, McGee RE, Druss BG
JAMA Psychiatry 2015 Apr;72(4):334-41. doi: 10.1001/jamapsychiatry.2014.2502. PMID: 25671328Free PMC Article
An evidence-based clinical guideline for the diagnosis and treatment of lumbar disc herniation with radiculopathy.
Kreiner DS, Hwang SW, Easa JE, Resnick DK, Baisden JL, Bess S, Cho CH, DePalma MJ, Dougherty P 2nd, Fernand R, Ghiselli G, Hanna AS, Lamer T, Lisi AJ, Mazanec DJ, Meagher RJ, Nucci RC, Patel RD, Sembrano JN, Sharma AK, Summers JT, Taleghani CK, Tontz WL Jr, Toton JF; North American Spine Society
Spine J 2014 Jan;14(1):180-91. Epub 2013 Nov 14 doi: 10.1016/j.spinee.2013.08.003. PMID: 24239490

Supplemental Content

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