U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Frey syndrome(HYPRG)

MedGen UID:
21041
•Concept ID:
C0038994
•
Disease or Syndrome
Synonyms: Auriculotemporal nerve syndrome; Frey's syndrome; Hyperhidrosis gustatory; Sweating, Gustatory
SNOMED CT: Gustatory hyperhidrosis (238758008); Gustatory sweating (56046002)
 
HPO: HP:0025277
Monarch Initiative: MONDO:0007753
OMIM®: 144100

Definition

Gustatory sweating results from a disruption of the auriculotemporal nerve pathways. Damage to the nerve may cause a misdirected regrowth that results in parasympathetic innervation of sympathetic receptors and, therefore, facial sweating and flushing with gustatory stimulation (summary by Dunbar et al., 2002). [from OMIM]

Clinical features

From HPO
Hyperhidrosis
MedGen UID:
5690
•Concept ID:
C0020458
•
Finding
Abnormal excessive perspiration (sweating) despite the lack of appropriate stimuli like hot and humid weather.
See: Feature record | Search on this feature

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFrey syndrome

Professional guidelines

PubMed

Botulinum Toxin Treatment for Cancer-Related Disorders: A Systematic Review.
Safarpour D, Jabbari B
Toxins (Basel) 2023 Dec 8;15(12) doi: 10.3390/toxins15120689. PMID: 38133193Free PMC Article
Management of Frey syndrome.
de Bree R, van der Waal I, Leemans CR
Head Neck 2007 Aug;29(8):773-8. doi: 10.1002/hed.20568. PMID: 17230557
A review of the surgical and medical treatment of Frey syndrome.
Clayman MA, Clayman SM, Seagle MB
Ann Plast Surg 2006 Nov;57(5):581-4. doi: 10.1097/01.sap.0000237085.59782.65. PMID: 17060744

Recent clinical studies

Etiology

Superficial Parotidectomy: Impact of Postoperative Drainage.
Nielsen CF, Riis CBS, Christensen ALB, Mirz F, Reinholdt KB, Ovesen T, Fjaeldstad AW
Ear Nose Throat J 2022 Feb;101(2):105-109. Epub 2020 Aug 3 doi: 10.1177/0145561320942380. PMID: 32744902
Outpatient vs inpatient parotidectomy: Systematic review and meta-analysis.
Benito DA, Pasick LJ, Bestourous D, Thakkar P, Goodman JF, Joshi AS
Head Neck 2021 Feb;43(2):668-678. Epub 2020 Oct 3 doi: 10.1002/hed.26482. PMID: 33009691
Frey Syndrome.
Blanc S, Bourrier T, Boralevi F, Sabouraud-Leclerc D, Pham-Thi N, Couderc L, Deschildre A, Dutau G, Albertini M, Tran A, Giovannini-Chami L; Frey Syndrome Collaborators
J Pediatr 2016 Jul;174:211-217.e2. Epub 2016 May 2 doi: 10.1016/j.jpeds.2016.03.070. PMID: 27157448
The role of parotidectomy in Sjögren's syndrome.
Madero-Visbal R, Milas Z
Oral Maxillofac Surg Clin North Am 2014 Feb;26(1):83-90. doi: 10.1016/j.coms.2013.09.007. PMID: 24287196
Management of Frey syndrome.
de Bree R, van der Waal I, Leemans CR
Head Neck 2007 Aug;29(8):773-8. doi: 10.1002/hed.20568. PMID: 17230557

Diagnosis

Infantile Frey syndrome.
Courtney A, Su JC
BMJ Case Rep 2024 Sep 3;17(9) doi: 10.1136/bcr-2024-260571. PMID: 39231561
Auriculotemporal Frey syndrome not associated with surgery or diabetes: systematic review.
Betti C, Milani GP, Lava SAG, Bianchetti MG, Bronz G, Ramelli GP, Goeggel Simonetti B, Bergmann MM
Eur J Pediatr 2022 May;181(5):2127-2134. Epub 2022 Feb 19 doi: 10.1007/s00431-022-04415-w. PMID: 35182195Free PMC Article
Superficial Parotidectomy: Impact of Postoperative Drainage.
Nielsen CF, Riis CBS, Christensen ALB, Mirz F, Reinholdt KB, Ovesen T, Fjaeldstad AW
Ear Nose Throat J 2022 Feb;101(2):105-109. Epub 2020 Aug 3 doi: 10.1177/0145561320942380. PMID: 32744902
Teaching NeuroImages: Frey syndrome.
Shcherbina A, Sader E
Neurology 2019 Nov 19;93(21):e1993-e1994. doi: 10.1212/WNL.0000000000008530. PMID: 31740517
Frey Syndrome.
Blanc S, Bourrier T, Boralevi F, Sabouraud-Leclerc D, Pham-Thi N, Couderc L, Deschildre A, Dutau G, Albertini M, Tran A, Giovannini-Chami L; Frey Syndrome Collaborators
J Pediatr 2016 Jul;174:211-217.e2. Epub 2016 May 2 doi: 10.1016/j.jpeds.2016.03.070. PMID: 27157448

Therapy

Botulinum Toxin Treatment for Cancer-Related Disorders: A Systematic Review.
Safarpour D, Jabbari B
Toxins (Basel) 2023 Dec 8;15(12) doi: 10.3390/toxins15120689. PMID: 38133193Free PMC Article
Use of Botulinum Toxin in Orofacial Clinical Practice.
Serrera-Figallo MA, Ruiz-de-León-Hernández G, Torres-Lagares D, Castro-Araya A, Torres-Ferrerosa O, Hernández-Pacheco E, Gutierrez-Perez JL
Toxins (Basel) 2020 Feb 11;12(2) doi: 10.3390/toxins12020112. PMID: 32053883Free PMC Article
Controversies in Parotid Defect Reconstruction.
Tamplen M, Knott PD, Fritz MA, Seth R
Facial Plast Surg Clin North Am 2016 Aug;24(3):235-43. Epub 2016 May 24 doi: 10.1016/j.fsc.2016.03.002. PMID: 27400838
Auriculotemporal Syndrome (Frey Syndrome).
Motz KM, Kim YJ
Otolaryngol Clin North Am 2016 Apr;49(2):501-9. Epub 2016 Feb 20 doi: 10.1016/j.otc.2015.10.010. PMID: 26902982Free PMC Article
Painful sweating.
Goldstein DS, Pechnik S, Moak J, Eldadah B
Neurology 2004 Oct 26;63(8):1471-5. doi: 10.1212/01.wnl.0000142037.06255.a8. PMID: 15505167

Prognosis

Mucoepidermoid carcinoma of the head and neck in children.
Dombrowski ND, Wolter NE, Irace AL, Cunningham MJ, Mack JW, Marcus KJ, Vargas SO, Perez-Atayde AR, Robson CD, Rahbar R
Int J Pediatr Otorhinolaryngol 2019 May;120:93-99. Epub 2019 Feb 10 doi: 10.1016/j.ijporl.2019.02.020. PMID: 30772619
Temporoparietal frey syndrome: An uncommon variant of a common syndrome.
Wood CB, Netterville JL
Laryngoscope 2019 Sep;129(9):2071-2075. Epub 2018 Dec 20 doi: 10.1002/lary.27632. PMID: 30570147
Frey Syndrome, First Bite Syndrome, great auricular nerve morbidity, and quality of life following parotidectomy.
Fiacchini G, Cerchiai N, Tricò D, Sellari-Franceschini S, Casani AP, Dallan I, Seccia V
Eur Arch Otorhinolaryngol 2018 Jul;275(7):1893-1902. Epub 2018 May 26 doi: 10.1007/s00405-018-5014-4. PMID: 29804129
Predictors for Frey Syndrome Development After Parotidectomy.
Lee CC, Chan RC, Chan JY
Ann Plast Surg 2017 Jul;79(1):39-41. doi: 10.1097/SAP.0000000000000993. PMID: 28609397
Frey syndrome: factors influencing the time to event.
Lafont M, Whyte A, Whyte J, Saura E, Tejedor MT
Int J Oral Maxillofac Surg 2015 Jul;44(7):834-9. Epub 2015 Feb 28 doi: 10.1016/j.ijom.2015.02.010. PMID: 25735534

Clinical prediction guides

Prevalence of Frey syndrome following extraoral surgical treatment for mandibular fractures: a systematic review and meta-analysis.
Kostares E, Kostares M, Kostare G, Kantzanou M
F1000Res 2023;12:1153. Epub 2023 Nov 30 doi: 10.12688/f1000research.140994.2. PMID: 38106653Free PMC Article
What is the best method for prevention of postparotidectomy Frey syndrome? Network meta-analysis.
Mashrah MA, Aldhohrah T, Abdelrehem A, Koraitim M, Wang L
Head Neck 2021 Apr;43(4):1345-1358. Epub 2021 Jan 13 doi: 10.1002/hed.26597. PMID: 33439485
Endoscopic versus conventional parotid gland excision: a systematic review and meta-analysis.
Moori PL, Rahman S
Br J Oral Maxillofac Surg 2021 Apr;59(3):272-280. Epub 2020 Aug 28 doi: 10.1016/j.bjoms.2020.08.103. PMID: 33280943
Frey Syndrome.
Blanc S, Bourrier T, Boralevi F, Sabouraud-Leclerc D, Pham-Thi N, Couderc L, Deschildre A, Dutau G, Albertini M, Tran A, Giovannini-Chami L; Frey Syndrome Collaborators
J Pediatr 2016 Jul;174:211-217.e2. Epub 2016 May 2 doi: 10.1016/j.jpeds.2016.03.070. PMID: 27157448
Use of the SMAS flap for reconstruction of the parotid lodge.
Dell'Aversana Orabona G, Salzano G, Abbate V, Piombino P, Astarita F, Iaconetta G, Califano L
Acta Otorhinolaryngol Ital 2015 Dec;35(6):406-11. doi: 10.14639/0392-100X-395. PMID: 26900246Free PMC Article

Recent systematic reviews

Botulinum Toxin Treatment for Cancer-Related Disorders: A Systematic Review.
Safarpour D, Jabbari B
Toxins (Basel) 2023 Dec 8;15(12) doi: 10.3390/toxins15120689. PMID: 38133193Free PMC Article
Prevalence of Frey syndrome following extraoral surgical treatment for mandibular fractures: a systematic review and meta-analysis.
Kostares E, Kostares M, Kostare G, Kantzanou M
F1000Res 2023;12:1153. Epub 2023 Nov 30 doi: 10.12688/f1000research.140994.2. PMID: 38106653Free PMC Article
Auriculotemporal Frey syndrome not associated with surgery or diabetes: systematic review.
Betti C, Milani GP, Lava SAG, Bianchetti MG, Bronz G, Ramelli GP, Goeggel Simonetti B, Bergmann MM
Eur J Pediatr 2022 May;181(5):2127-2134. Epub 2022 Feb 19 doi: 10.1007/s00431-022-04415-w. PMID: 35182195Free PMC Article
Outpatient vs inpatient parotidectomy: Systematic review and meta-analysis.
Benito DA, Pasick LJ, Bestourous D, Thakkar P, Goodman JF, Joshi AS
Head Neck 2021 Feb;43(2):668-678. Epub 2020 Oct 3 doi: 10.1002/hed.26482. PMID: 33009691
AlloDerm implants for prevention of Frey syndrome after parotidectomy: a systematic review and meta-analysis.
Zeng XT, Tang XJ, Wang XJ, Li MZ, Guo Y, Huang W, Niu YM, Leng WD
Mol Med Rep 2012 Apr;5(4):974-80. Epub 2012 Jan 20 doi: 10.3892/mmr.2012.762. PMID: 22266670Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Reviews

    Related information

    • MeSH
      Related Medical Subject Headings
    • OMIM
      Related records in OMIM
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...