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Syndromic dyslipidemia

MedGen UID:
1826171
•Concept ID:
C5680608
•
Disease or Syndrome
Synonyms: complex dyslipidaemia; complex dyslipidemia; rare syndromic dyslipidaemia; rare syndromic dyslipidemia; Rare syndromic dyslipidemia; syndrome associated with inherited lipid metabolism disorder; syndromic dyslipidemia; syndromic inherited lipid metabolism disorder
 
Monarch Initiative: MONDO:0015905
Orphanet: ORPHA181437

Definition

A inherited lipid metabolism disorder that is part of a larger syndrome. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSyndromic dyslipidemia

Professional guidelines

PubMed

American Association of Clinical Endocrinology Clinical Practice Guideline: Developing a Diabetes Mellitus Comprehensive Care Plan-2022 Update.
Blonde L, Umpierrez GE, Reddy SS, McGill JB, Berga SL, Bush M, Chandrasekaran S, DeFronzo RA, Einhorn D, Galindo RJ, Gardner TW, Garg R, Garvey WT, Hirsch IB, Hurley DL, Izuora K, Kosiborod M, Olson D, Patel SB, Pop-Busui R, Sadhu AR, Samson SL, Stec C, Tamborlane WV Jr, Tuttle KR, Twining C, Vella A, Vellanki P, Weber SL
Endocr Pract 2022 Oct;28(10):923-1049. Epub 2022 Aug 11 doi: 10.1016/j.eprac.2022.08.002. PMID: 35963508Free PMC Article
The Diagnosis and Treatment of Hypertriglyceridemia.
Parhofer KG, Laufs U
Dtsch Arztebl Int 2019 Dec 6;116(49):825-832. doi: 10.3238/arztebl.2019.0825. PMID: 31888796Free PMC Article
2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines.
Grundy SM, Stone NJ, Bailey AL, Beam C, Birtcher KK, Blumenthal RS, Braun LT, de Ferranti S, Faiella-Tommasino J, Forman DE, Goldberg R, Heidenreich PA, Hlatky MA, Jones DW, Lloyd-Jones D, Lopez-Pajares N, Ndumele CE, Orringer CE, Peralta CA, Saseen JJ, Smith SC Jr, Sperling L, Virani SS, Yeboah J
Circulation 2019 Jun 18;139(25):e1082-e1143. Epub 2018 Nov 10 doi: 10.1161/CIR.0000000000000625. PMID: 30586774Free PMC Article

Recent clinical studies

Etiology

Obesity and Dyslipidemia.
Nussbaumerova B, Rosolova H
Curr Atheroscler Rep 2023 Dec;25(12):947-955. Epub 2023 Nov 18 doi: 10.1007/s11883-023-01167-2. PMID: 37979064
A Modern Approach to Dyslipidemia.
Berberich AJ, Hegele RA
Endocr Rev 2022 Jul 13;43(4):611-653. doi: 10.1210/endrev/bnab037. PMID: 34676866Free PMC Article
Global epidemiology of dyslipidaemias.
Pirillo A, Casula M, Olmastroni E, Norata GD, Catapano AL
Nat Rev Cardiol 2021 Oct;18(10):689-700. Epub 2021 Apr 8 doi: 10.1038/s41569-021-00541-4. PMID: 33833450
Dysregulated lipid metabolism links NAFLD to cardiovascular disease.
Deprince A, Haas JT, Staels B
Mol Metab 2020 Dec;42:101092. Epub 2020 Oct 1 doi: 10.1016/j.molmet.2020.101092. PMID: 33010471Free PMC Article
Metabolic syndrome update.
Grundy SM
Trends Cardiovasc Med 2016 May;26(4):364-73. Epub 2015 Oct 31 doi: 10.1016/j.tcm.2015.10.004. PMID: 26654259

Diagnosis

Hypertriglyceridaemia: an update.
Wierzbicki AS, Kim EJ, Esan O, Ramachandran R
J Clin Pathol 2022 Dec;75(12):798-806. Epub 2022 Jun 16 doi: 10.1136/jclinpath-2021-207719. PMID: 35710321
A Modern Approach to Dyslipidemia.
Berberich AJ, Hegele RA
Endocr Rev 2022 Jul 13;43(4):611-653. doi: 10.1210/endrev/bnab037. PMID: 34676866Free PMC Article
Metabolic syndrome and peripheral neuropathy.
Kazamel M, Stino AM, Smith AG
Muscle Nerve 2021 Mar;63(3):285-293. Epub 2020 Oct 24 doi: 10.1002/mus.27086. PMID: 33098165
Nephrotic Syndrome.
Politano SA, Colbert GB, Hamiduzzaman N
Prim Care 2020 Dec;47(4):597-613. Epub 2020 Sep 26 doi: 10.1016/j.pop.2020.08.002. PMID: 33121631
Metabolic syndrome update.
Grundy SM
Trends Cardiovasc Med 2016 May;26(4):364-73. Epub 2015 Oct 31 doi: 10.1016/j.tcm.2015.10.004. PMID: 26654259

Therapy

Metabolic syndrome and peripheral neuropathy.
Kazamel M, Stino AM, Smith AG
Muscle Nerve 2021 Mar;63(3):285-293. Epub 2020 Oct 24 doi: 10.1002/mus.27086. PMID: 33098165
The Diagnosis and Treatment of Hypertriglyceridemia.
Parhofer KG, Laufs U
Dtsch Arztebl Int 2019 Dec 6;116(49):825-832. doi: 10.3238/arztebl.2019.0825. PMID: 31888796Free PMC Article
Dyslipidaemia in nephrotic syndrome: mechanisms and treatment.
Agrawal S, Zaritsky JJ, Fornoni A, Smoyer WE
Nat Rev Nephrol 2018 Jan;14(1):57-70. Epub 2017 Nov 27 doi: 10.1038/nrneph.2017.155. PMID: 29176657Free PMC Article
Metabolic syndrome update.
Grundy SM
Trends Cardiovasc Med 2016 May;26(4):364-73. Epub 2015 Oct 31 doi: 10.1016/j.tcm.2015.10.004. PMID: 26654259
Dyslipidemia in obesity: mechanisms and potential targets.
Klop B, Elte JW, Cabezas MC
Nutrients 2013 Apr 12;5(4):1218-40. doi: 10.3390/nu5041218. PMID: 23584084Free PMC Article

Prognosis

Association between sleep duration and metabolic syndrome: linear and nonlinear Mendelian randomization analyses.
Liang YY, Chen J, Peng M, Zhou J, Chen X, Tan X, Wang N, Ma H, Guo L, Zhang J, Wing YK, Geng Q, Ai S
J Transl Med 2023 Feb 7;21(1):90. doi: 10.1186/s12967-023-03920-2. PMID: 36747249Free PMC Article
Metabolic syndrome and peripheral neuropathy.
Kazamel M, Stino AM, Smith AG
Muscle Nerve 2021 Mar;63(3):285-293. Epub 2020 Oct 24 doi: 10.1002/mus.27086. PMID: 33098165
Aortic dissection.
Nienaber CA, Clough RE, Sakalihasan N, Suzuki T, Gibbs R, Mussa F, Jenkins MP, Thompson MM, Evangelista A, Yeh JS, Cheshire N, Rosendahl U, Pepper J
Nat Rev Dis Primers 2016 Jul 21;2:16053. doi: 10.1038/nrdp.2016.53. PMID: 27440162
Neuroacanthocytosis syndromes.
Jung HH, Danek A, Walker RH
Orphanet J Rare Dis 2011 Oct 25;6:68. doi: 10.1186/1750-1172-6-68. PMID: 22027213Free PMC Article
Diabetes and dyslipidaemia.
Schwartz SL
Diabetes Obes Metab 2006 Jul;8(4):355-64. doi: 10.1111/j.1463-1326.2005.00516.x. PMID: 16776742

Clinical prediction guides

Association between sleep duration and metabolic syndrome: linear and nonlinear Mendelian randomization analyses.
Liang YY, Chen J, Peng M, Zhou J, Chen X, Tan X, Wang N, Ma H, Guo L, Zhang J, Wing YK, Geng Q, Ai S
J Transl Med 2023 Feb 7;21(1):90. doi: 10.1186/s12967-023-03920-2. PMID: 36747249Free PMC Article
Metabolic syndrome and peripheral neuropathy.
Kazamel M, Stino AM, Smith AG
Muscle Nerve 2021 Mar;63(3):285-293. Epub 2020 Oct 24 doi: 10.1002/mus.27086. PMID: 33098165
Dysregulated lipid metabolism links NAFLD to cardiovascular disease.
Deprince A, Haas JT, Staels B
Mol Metab 2020 Dec;42:101092. Epub 2020 Oct 1 doi: 10.1016/j.molmet.2020.101092. PMID: 33010471Free PMC Article
Benefits and Risks of Bariatric Surgery in Adults: A Review.
Arterburn DE, Telem DA, Kushner RF, Courcoulas AP
JAMA 2020 Sep 1;324(9):879-887. doi: 10.1001/jama.2020.12567. PMID: 32870301
Metabolic syndrome--practical approach.
Hâncu N, Roman G, Nită C, Negrean M
Rom J Intern Med 2004;42(2):237-45. PMID: 15529614

Recent systematic reviews

Ultra-Processed Food Consumption and Incidence of Obesity and Cardiometabolic Risk Factors in Adults: A Systematic Review of Prospective Studies.
Mambrini SP, Menichetti F, Ravella S, Pellizzari M, De Amicis R, Foppiani A, Battezzati A, Bertoli S, Leone A
Nutrients 2023 May 31;15(11) doi: 10.3390/nu15112583. PMID: 37299546Free PMC Article
Normal Weight Obesity and Cardiometabolic Risk Factors: A Systematic Review and Meta-Analysis.
Mohammadian Khonsari N, Khashayar P, Shahrestanaki E, Kelishadi R, Mohammadpoor Nami S, Heidari-Beni M, Esmaeili Abdar Z, Tabatabaei-Malazy O, Qorbani M
Front Endocrinol (Lausanne) 2022;13:857930. Epub 2022 Mar 24 doi: 10.3389/fendo.2022.857930. PMID: 35399938Free PMC Article
Ultraprocessed food and chronic noncommunicable diseases: A systematic review and meta-analysis of 43 observational studies.
Lane MM, Davis JA, Beattie S, Gómez-Donoso C, Loughman A, O'Neil A, Jacka F, Berk M, Page R, Marx W, Rocks T
Obes Rev 2021 Mar;22(3):e13146. Epub 2020 Nov 9 doi: 10.1111/obr.13146. PMID: 33167080
Cardiovascular Changes in Menopause.
Nair AR, Pillai AJ, Nair N
Curr Cardiol Rev 2021;17(4):e230421187681. doi: 10.2174/1573403X16666201106141811. PMID: 33155924Free PMC Article
2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines.
Grundy SM, Stone NJ, Bailey AL, Beam C, Birtcher KK, Blumenthal RS, Braun LT, de Ferranti S, Faiella-Tommasino J, Forman DE, Goldberg R, Heidenreich PA, Hlatky MA, Jones DW, Lloyd-Jones D, Lopez-Pajares N, Ndumele CE, Orringer CE, Peralta CA, Saseen JJ, Smith SC Jr, Sperling L, Virani SS, Yeboah J
Circulation 2019 Jun 18;139(25):e1082-e1143. Epub 2018 Nov 10 doi: 10.1161/CIR.0000000000000625. PMID: 30586774Free PMC Article

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