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Abnormal urinary pyrimidine level

MedGen UID:: 1734415
•Concept ID:: C5421653
•: Finding

HPO:	HP:0033162

Definition

Any deviation from the normal amount of a pyrimidine compound in the urine. Pyrimidines and pyrimidine derivatives are compounds containing a pyrimidne ring, which is a six-member aromatic heterocycle which consists of two nitrogen atoms (at positions 1 and 3) and four carbon atoms. The nucleotides cytosine, thymine and uracil are pyrimidines. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVAbnormal urinary pyrimidine level

Abnormality of the genitourinary system
- Abnormality of the urinary system
  - Abnormality of the urinary system physiology
    - Abnormality of urine homeostasis
      - Abnormal urine metabolite level
        Abnormal urinary nucleobase concentration
        Abnormal urinary pyrimidine level
        Elevated urinary 5-hydroxymethyluracil level
        Elevated urinary cytidine
        Elevated urinary deoxyuridine level
        Elevated urinary dihydrothymine level
        Elevated urinary dihydrouracil level
        Elevated urinary quinolinic acid level
        Elevated urinary thymidine level
        Elevated urinary thymine level
        Elevated urinary uridine level
        Uraciluria

Professional guidelines

PubMed

Management of Fever in Infants and Young Children.

Hamilton JL, Evans SG, Bakshi M
Am Fam Physician 2020 Jun 15;101(12):721-729. PMID: 32538597

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Recent clinical studies

Etiology

Management of Fever in Infants and Young Children.

Hamilton JL, Evans SG, Bakshi M
Am Fam Physician 2020 Jun 15;101(12):721-729. PMID: 32538597

Urinary metabolomics of young Italian autistic children supports abnormal tryptophan and purine metabolism.

Gevi F, Zolla L, Gabriele S, Persico AM
Mol Autism 2016;7:47. Epub 2016 Nov 24 doi: 10.1186/s13229-016-0109-5. PMID: 27904735 Free PMC Article

Mode of action of pulegone on the urinary bladder of F344 rats.

Da Rocha MS, Dodmane PR, Arnold LL, Pennington KL, Anwar MM, Adams BR, Taylor SV, Wermes C, Adams TB, Cohen SM
Toxicol Sci 2012 Jul;128(1):1-8. Epub 2012 Apr 12 doi: 10.1093/toxsci/kfs135. PMID: 22499580

Henoch-Schönlein purpura with hypocomplementemia.

Lin Q, Min Y, Li Y, Zhu Y, Song X, Xu Q, Wang L, Cheng J, Feng Q, Li X
Pediatr Nephrol 2012 May;27(5):801-6. Epub 2012 Jan 21 doi: 10.1007/s00467-011-2070-z. PMID: 22271365

Allopurinol challenge test in children.

Burlina AB, Ferrari V, Dionisi-Vici C, Bordugo A, Zacchello F, Tuchman M
J Inherit Metab Dis 1992;15(5):707-12. doi: 10.1007/BF01800010. PMID: 1434508

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Diagnosis

Management of Fever in Infants and Young Children.

Hamilton JL, Evans SG, Bakshi M
Am Fam Physician 2020 Jun 15;101(12):721-729. PMID: 32538597

Urinary metabolomics of young Italian autistic children supports abnormal tryptophan and purine metabolism.

Gevi F, Zolla L, Gabriele S, Persico AM
Mol Autism 2016;7:47. Epub 2016 Nov 24 doi: 10.1186/s13229-016-0109-5. PMID: 27904735 Free PMC Article

Henoch-Schönlein purpura with hypocomplementemia.

Lin Q, Min Y, Li Y, Zhu Y, Song X, Xu Q, Wang L, Cheng J, Feng Q, Li X
Pediatr Nephrol 2012 May;27(5):801-6. Epub 2012 Jan 21 doi: 10.1007/s00467-011-2070-z. PMID: 22271365

The importance of uric acid examination.

Sebesta I, Krijt J, Schneiderka P
Sb Lek 1994;95(4):383-9. PMID: 8867710

A quantitative approach to determining disease response during therapy using multiple biologic markers: application to carcinoma of the breast.

Woo KB, Waalkes TP, Ahmann DL, Tormey DC, Gehrke CW, Oliverio VT
Cancer 1978 May;41(5):1685-703. doi: 10.1002/1097-0142(197805)41:5<1685::aid-cncr2820410507>3.0.co;2-9. PMID: 348295

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Therapy

Management of Fever in Infants and Young Children.

Hamilton JL, Evans SG, Bakshi M
Am Fam Physician 2020 Jun 15;101(12):721-729. PMID: 32538597

Switching Lamivudine with Adefovir Dipivoxil Combination Therapy to Entecavir Monotherapy Provides Better Viral Suppression and Kidney Safety.

Lian JS, Zhang XL, Lu YF, Chen JY, Zhang YM, Jia HY, Zhang Z, Yang YD
Int J Med Sci 2019;16(1):17-22. Epub 2019 Jan 1 doi: 10.7150/ijms.28700. PMID: 30662324 Free PMC Article

Henoch-Schönlein purpura with hypocomplementemia.

Lin Q, Min Y, Li Y, Zhu Y, Song X, Xu Q, Wang L, Cheng J, Feng Q, Li X
Pediatr Nephrol 2012 May;27(5):801-6. Epub 2012 Jan 21 doi: 10.1007/s00467-011-2070-z. PMID: 22271365

5-Fluorouracil, dacarbazine, and epirubicin in the treatment of patients with neuroendocrine tumors.

Bajetta E, Rimassa L, Carnaghi C, Seregni E, Ferrari L, Di Bartolomeo M, Regalia E, Cassata A, Procopio G, Mariani L
Cancer 1998 Jul 15;83(2):372-8. doi: 10.1002/(sici)1097-0142(19980715)83:2<372::aid-cncr23>3.0.co;2-p. PMID: 9669822

Possible prediction of adverse reactions to pyrimidine chemotherapy from urinary pyrimidine levels and a case of asymptomatic adult dihydropyrimidinuria.

Hayashi K, Kidouchi K, Sumi S, Mizokami M, Orito E, Kumada K, Ueda R, Wada Y
Clin Cancer Res 1996 Dec;2(12):1937-41. PMID: 9816152

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Prognosis

NAT10-mediated mRNA N4-acetylcytidine modification promotes bladder cancer progression.

Wang G, Zhang M, Zhang Y, Xie Y, Zou J, Zhong J, Zheng Z, Zhou X, Zheng Y, Chen B, Liu C
Clin Transl Med 2022 May;12(5):e738. doi: 10.1002/ctm2.738. PMID: 35522942 Free PMC Article

Plasma metabolites and lipids associate with kidney function and kidney volume in hypertensive ADPKD patients early in the disease course.

Kim K, Trott JF, Gao G, Chapman A, Weiss RH
BMC Nephrol 2019 Feb 25;20(1):66. doi: 10.1186/s12882-019-1249-6. PMID: 30803434 Free PMC Article

Henoch-Schönlein purpura with hypocomplementemia.

Lin Q, Min Y, Li Y, Zhu Y, Song X, Xu Q, Wang L, Cheng J, Feng Q, Li X
Pediatr Nephrol 2012 May;27(5):801-6. Epub 2012 Jan 21 doi: 10.1007/s00467-011-2070-z. PMID: 22271365

Possible prediction of adverse reactions to pyrimidine chemotherapy from urinary pyrimidine levels and a case of asymptomatic adult dihydropyrimidinuria.

Hayashi K, Kidouchi K, Sumi S, Mizokami M, Orito E, Kumada K, Ueda R, Wada Y
Clin Cancer Res 1996 Dec;2(12):1937-41. PMID: 9816152

Inherited biochemical defects affecting the kidney.

Caskey CT
Perspect Nephrol Hypertens 1976;3:255-74. PMID: 765953

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Clinical prediction guides

NAT10-mediated mRNA N4-acetylcytidine modification promotes bladder cancer progression.

Wang G, Zhang M, Zhang Y, Xie Y, Zou J, Zhong J, Zheng Z, Zhou X, Zheng Y, Chen B, Liu C
Clin Transl Med 2022 May;12(5):e738. doi: 10.1002/ctm2.738. PMID: 35522942 Free PMC Article

Management of Fever in Infants and Young Children.

Hamilton JL, Evans SG, Bakshi M
Am Fam Physician 2020 Jun 15;101(12):721-729. PMID: 32538597

Urinary metabolomics of young Italian autistic children supports abnormal tryptophan and purine metabolism.

Gevi F, Zolla L, Gabriele S, Persico AM
Mol Autism 2016;7:47. Epub 2016 Nov 24 doi: 10.1186/s13229-016-0109-5. PMID: 27904735 Free PMC Article

Mode of action of pulegone on the urinary bladder of F344 rats.

Effect of oral contraceptive agents on nutrients: II. Vitamins.

Prasad AS, Oberleas D, Moghissi KS, Stryker JC, Lei KY
Am J Clin Nutr 1975 Apr;28(4):385-91. doi: 10.1093/ajcn/28.4.385. PMID: 1168019

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