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Metastatic Undifferentiated Pleomorphic Sarcoma

MedGen UID:
149257
•Concept ID:
C0740346
•
Neoplastic Process
Synonyms: Metastatic Unclassified Pleomorphic Sarcoma; Metastatic Unclassified Pleomorphic Sarcoma (Formerly Metastatic "Malignant Fibrous Histiocytoma"); Metastatic Unclassified Pleomorphic Sarcoma (Formerly Metastatic "MFH")

Definition

An undifferentiated pleomorphic sarcoma that has spread to other anatomic sites. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Undifferentiated Pleomorphic Sarcoma

Professional guidelines

PubMed

Biology and Management of High-Grade Chondrosarcoma: An Update on Targets and Treatment Options.
Tlemsani C, Larousserie F, De Percin S, Audard V, Hadjadj D, Chen J, Biau D, Anract P, Terris B, Goldwasser F, Pasmant E, Boudou-Rouquette P
Int J Mol Sci 2023 Jan 10;24(2) doi: 10.3390/ijms24021361. PMID: 36674874Free PMC Article
Management of the Hand Tumors.
Datta NK, Das KP, Aish PK, Datta M, Banik SK, Sen SK, Chowdhury RM
Mymensingh Med J 2023 Jan;32(1):135-143. PMID: 36594313
The Management of Head and Neck Sarcoma.
Han S, Yin X, Xu W, Wang Y, Han W
J Craniofac Surg 2020 Mar/Apr;31(2):e189-e192. doi: 10.1097/SCS.0000000000006162. PMID: 31934973

Recent clinical studies

Etiology

Aggressive Skin Cancers Occurring in Patients Treated With the Janus Kinase Inhibitor Ruxolitinib.
Blechman AB, Cabell CE, Weinberger CH, Duckworth A, Leitenberger JJ, Zwald FO, Russell MA
J Drugs Dermatol 2017 May 1;16(5):508-511. PMID: 28628689
Metastatic undifferentiated pleomorphic sarcoma causing intraoperative stroke.
Spaulding R 4th, Koumoundouros T, Parker JC Jr
Ann Clin Lab Sci 2013 Spring;43(2):172-5. PMID: 23694792

Diagnosis

Tumor Lysis Syndrome due to Eribulin Administration for Metastatic Undifferentiated Pleomorphic Sarcoma of the Buttock.
Tsuchie H, Miyakoshi N, Nagasawa H, Shimada Y
Acta Med Okayama 2021 Aug;75(4):533-538. doi: 10.18926/AMO/62408. PMID: 34511623
Aggressive Skin Cancers Occurring in Patients Treated With the Janus Kinase Inhibitor Ruxolitinib.
Blechman AB, Cabell CE, Weinberger CH, Duckworth A, Leitenberger JJ, Zwald FO, Russell MA
J Drugs Dermatol 2017 May 1;16(5):508-511. PMID: 28628689
Metastatic undifferentiated pleomorphic sarcoma causing intraoperative stroke.
Spaulding R 4th, Koumoundouros T, Parker JC Jr
Ann Clin Lab Sci 2013 Spring;43(2):172-5. PMID: 23694792

Therapy

Unexpected Durable Complete Response With Anti-PD-L1 Blockade in Metastatic Undifferentiated Pleomorphic Sarcoma: A Case Report With Host and Tumor Biomarker Analysis.
Pesántez D, Indacochea A, Angelats L, Sirico M, Victoria I, Sanfeliu E, Teixido C, González-Navarro AE, Galván P, Brasó-Maristany F, Jares P, Juan M, Prat A, Schettini F, García-Corbacho J
JCO Precis Oncol 2023 Sep;7:e2300051. doi: 10.1200/PO.23.00051. PMID: 37856765
Tumor Lysis Syndrome due to Eribulin Administration for Metastatic Undifferentiated Pleomorphic Sarcoma of the Buttock.
Tsuchie H, Miyakoshi N, Nagasawa H, Shimada Y
Acta Med Okayama 2021 Aug;75(4):533-538. doi: 10.18926/AMO/62408. PMID: 34511623
Exceptional Long-lasting Clinical Benefit of Trabectedin in a Patient With Metastatic Undifferentiated Pleomorphic Sarcoma: Postscriptum From the T-Dis Trial.
Penel N, Decoupigny E, Tresch-Bruneel E, Le Cesne A, Taieb S, Isambert N
Am J Clin Oncol 2019 Sep;42(9):737. doi: 10.1097/COC.0000000000000576. PMID: 31449140
Aggressive Skin Cancers Occurring in Patients Treated With the Janus Kinase Inhibitor Ruxolitinib.
Blechman AB, Cabell CE, Weinberger CH, Duckworth A, Leitenberger JJ, Zwald FO, Russell MA
J Drugs Dermatol 2017 May 1;16(5):508-511. PMID: 28628689

Prognosis

Tumor Lysis Syndrome due to Eribulin Administration for Metastatic Undifferentiated Pleomorphic Sarcoma of the Buttock.
Tsuchie H, Miyakoshi N, Nagasawa H, Shimada Y
Acta Med Okayama 2021 Aug;75(4):533-538. doi: 10.18926/AMO/62408. PMID: 34511623
Exceptional Long-lasting Clinical Benefit of Trabectedin in a Patient With Metastatic Undifferentiated Pleomorphic Sarcoma: Postscriptum From the T-Dis Trial.
Penel N, Decoupigny E, Tresch-Bruneel E, Le Cesne A, Taieb S, Isambert N
Am J Clin Oncol 2019 Sep;42(9):737. doi: 10.1097/COC.0000000000000576. PMID: 31449140
Metastatic undifferentiated pleomorphic sarcoma causing intraoperative stroke.
Spaulding R 4th, Koumoundouros T, Parker JC Jr
Ann Clin Lab Sci 2013 Spring;43(2):172-5. PMID: 23694792

Clinical prediction guides

Aggressive Skin Cancers Occurring in Patients Treated With the Janus Kinase Inhibitor Ruxolitinib.
Blechman AB, Cabell CE, Weinberger CH, Duckworth A, Leitenberger JJ, Zwald FO, Russell MA
J Drugs Dermatol 2017 May 1;16(5):508-511. PMID: 28628689

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