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Malignant Epiglottis Neoplasm

MedGen UID:
108321
•Concept ID:
C0585946
•
Neoplastic Process
Synonyms: Malignant Epiglottic Neoplasm; Malignant Epiglottic Tumor; Malignant Epiglottis Tumor; Malignant Neoplasm of Epiglottis; Malignant Neoplasm of the Epiglottis; Malignant Tumor of Epiglottis; Malignant Tumor of the Epiglottis

Definition

A malignant neoplasm that affects the epiglottis. The vast majority of cases are squamous cell carcinomas. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant Epiglottis Neoplasm

Professional guidelines

PubMed

Treatment of early-stage laryngeal cancer: A comparison of treatment options.
Baird BJ, Sung CK, Beadle BM, Divi V
Oral Oncol 2018 Dec;87:8-16. Epub 2018 Oct 16 doi: 10.1016/j.oraloncology.2018.09.012. PMID: 30527248
Evaluation of treatment outcomes in patients with supraglottic laryngeal cancer in Ontario, Canada: A population-based study.
Hall SF, Griffiths RJ
Head Neck 2018 May;40(5):1024-1033. Epub 2018 Feb 7 doi: 10.1002/hed.25073. PMID: 29412495
Management of the clinically negative neck (N0) of supraglottic laryngeal carcinoma: a systematic review.
Goudakos JK, Markou K, Nikolaou A, Themelis C, Vital V
Eur J Surg Oncol 2009 Mar;35(3):223-9. Epub 2008 May 12 doi: 10.1016/j.ejso.2008.04.001. PMID: 18468836

Recent clinical studies

Etiology

Videofluoroscopic Measures of Swallowing After Partial Epiglottidectomy for Dysphagia.
Chung HR, Reddy NK, Smith AF, Chhetri DK
Otolaryngol Head Neck Surg 2023 Aug;169(2):317-324. Epub 2023 Feb 5 doi: 10.1002/ohn.294. PMID: 36939459
Pignat's vertical partial laryngectomy with crico-hyoido-epiglotto-plasty.
Pecorari G, Perottino F, Riva G, Nora V, Poupart M, Zrounba P
Eur Arch Otorhinolaryngol 2022 Feb;279(2):979-986. Epub 2021 Jun 11 doi: 10.1007/s00405-021-06858-7. PMID: 34117535
Development and reliability of the revised Patterson Edema Scale.
Starmer HM, Drinnan M, Bhabra M, Watson LJ, Patterson J
Clin Otolaryngol 2021 Jul;46(4):752-757. Epub 2021 Feb 15 doi: 10.1111/coa.13727. PMID: 33529494
A Novel Laryngoscope-assisted Method for Sealing Pharyngocutaneous Fistula.
Du Z, Zhang CP, Wang YA
J Craniofac Surg 2021 Jun 1;32(4):e351-e353. doi: 10.1097/SCS.0000000000007127. PMID: 33027172
Well-differentiated liposarcoma of the epiglottis.
Pajaniappane A, Farzan J, Green DM, De M
J Laryngol Otol 2014 Mar;128(3):296-8. Epub 2014 Feb 13 doi: 10.1017/S0022215114000085. PMID: 24521797

Diagnosis

Pallister-Hall syndrome, GLI3, and kidney malformation.
McClelland K, Li W, Rosenblum ND
Am J Med Genet C Semin Med Genet 2022 Sep;190(3):264-278. Epub 2022 Sep 27 doi: 10.1002/ajmg.c.31999. PMID: 36165461
Schwannoma of the Supraglottis.
Gupta R, Azhdam AM, Borrelli M
Ear Nose Throat J 2021 Sep;100(6_suppl):879S-880S. Epub 2021 Jun 10 doi: 10.1177/01455613211018586. PMID: 34112006
Epiglottis Tuberculosis Mimicking Malignant Tumor.
Chang KM, Kang BH
Ear Nose Throat J 2021 May;100(4):NP171-NP172. Epub 2019 Sep 29 doi: 10.1177/0145561319871908. PMID: 31565999
Laryngeal chondrosarcoma: A systematic review of 592 cases.
Chin OY, Dubal PM, Sheikh AB, Unsal AA, Park RC, Baredes S, Eloy JA
Laryngoscope 2017 Feb;127(2):430-439. Epub 2016 Jun 12 doi: 10.1002/lary.26068. PMID: 27291822
Laryngeal schwannoma: a systematic review.
Wong BLK, Bathala S, Grant D
Eur Arch Otorhinolaryngol 2017 Jan;274(1):25-34. Epub 2016 Mar 28 doi: 10.1007/s00405-016-4013-6. PMID: 27020268

Therapy

Upright epiglottis prevents aspiration in patients with nasopharyngeal carcinoma post-chemoradiation.
Tamin S, Adham M, Noer A, Supriana N, Bardosono S
PLoS One 2021;16(12):e0261110. Epub 2021 Dec 9 doi: 10.1371/journal.pone.0261110. PMID: 34882745Free PMC Article
Pleomorphic adenoma of the epiglottis.
Alzate Amaya F, Invencio da Costa L, Álvarez-Buylla Blanco M
Acta Otorrinolaringol Esp (Engl Ed) 2019 Nov-Dec;70(6):376-377. Epub 2018 Dec 24 doi: 10.1016/j.otorri.2018.07.002. PMID: 30591211
Treatment of early-stage laryngeal cancer: A comparison of treatment options.
Baird BJ, Sung CK, Beadle BM, Divi V
Oral Oncol 2018 Dec;87:8-16. Epub 2018 Oct 16 doi: 10.1016/j.oraloncology.2018.09.012. PMID: 30527248
Nasogastric Tube Syndrome: A Diagnostic Dilemma.
Nayak G, Virk RS, Singh M, Singh M
J Bronchology Interv Pulmonol 2018 Oct;25(4):343-345. doi: 10.1097/LBR.0000000000000507. PMID: 29771772
Laryngeal lymphoscintigraphy.
Jackson BS, Rosenthall L, Attia E
Laryngoscope 1981 Dec;91(12):2085-91. doi: 10.1288/00005537-198112000-00010. PMID: 6459505

Prognosis

Pignat's vertical partial laryngectomy with crico-hyoido-epiglotto-plasty.
Pecorari G, Perottino F, Riva G, Nora V, Poupart M, Zrounba P
Eur Arch Otorhinolaryngol 2022 Feb;279(2):979-986. Epub 2021 Jun 11 doi: 10.1007/s00405-021-06858-7. PMID: 34117535
Treatment of early-stage laryngeal cancer: A comparison of treatment options.
Baird BJ, Sung CK, Beadle BM, Divi V
Oral Oncol 2018 Dec;87:8-16. Epub 2018 Oct 16 doi: 10.1016/j.oraloncology.2018.09.012. PMID: 30527248
Laryngeal chondrosarcoma: A systematic review of 592 cases.
Chin OY, Dubal PM, Sheikh AB, Unsal AA, Park RC, Baredes S, Eloy JA
Laryngoscope 2017 Feb;127(2):430-439. Epub 2016 Jun 12 doi: 10.1002/lary.26068. PMID: 27291822
Laryngeal schwannoma: a systematic review.
Wong BLK, Bathala S, Grant D
Eur Arch Otorhinolaryngol 2017 Jan;274(1):25-34. Epub 2016 Mar 28 doi: 10.1007/s00405-016-4013-6. PMID: 27020268
The laryngeal saccule: clinical significance.
Porter PW, Vilensky JA
Clin Anat 2012 Jul;25(5):647-9. Epub 2011 Dec 12 doi: 10.1002/ca.22015. PMID: 22162142

Clinical prediction guides

Videofluoroscopic Measures of Swallowing After Partial Epiglottidectomy for Dysphagia.
Chung HR, Reddy NK, Smith AF, Chhetri DK
Otolaryngol Head Neck Surg 2023 Aug;169(2):317-324. Epub 2023 Feb 5 doi: 10.1002/ohn.294. PMID: 36939459
Pallister-Hall syndrome, GLI3, and kidney malformation.
McClelland K, Li W, Rosenblum ND
Am J Med Genet C Semin Med Genet 2022 Sep;190(3):264-278. Epub 2022 Sep 27 doi: 10.1002/ajmg.c.31999. PMID: 36165461
Pignat's vertical partial laryngectomy with crico-hyoido-epiglotto-plasty.
Pecorari G, Perottino F, Riva G, Nora V, Poupart M, Zrounba P
Eur Arch Otorhinolaryngol 2022 Feb;279(2):979-986. Epub 2021 Jun 11 doi: 10.1007/s00405-021-06858-7. PMID: 34117535
Upright epiglottis prevents aspiration in patients with nasopharyngeal carcinoma post-chemoradiation.
Tamin S, Adham M, Noer A, Supriana N, Bardosono S
PLoS One 2021;16(12):e0261110. Epub 2021 Dec 9 doi: 10.1371/journal.pone.0261110. PMID: 34882745Free PMC Article
Laryngeal function after supracricoid laryngectomy.
Saito K, Araki K, Ogawa K, Shiotani A
Otolaryngol Head Neck Surg 2009 Apr;140(4):487-92. doi: 10.1016/j.otohns.2008.12.036. PMID: 19328335

Recent systematic reviews

Cancer of the Larynx-20-Year Comparative Survival and Mortality Analysis by Age, Sex, Race, Stage, Grade, Cohort Entry Time-Period, Disease Duration and ICD-O-3 Topographic Primary Sites-Codes C32.0-9: A Systematic Review of 43,103 Cases for Diagnosis Years 1975-2017: (NCI SEER*Stat 8.3.9).
Milano AF
J Insur Med 2024 Jul 1;51(2):92-110. doi: 10.17849/insm-51-2-92-110.1. PMID: 39266004
Features related to temporary tracheotomy in patients undergoing Transoral Robotic Surgery (TORS) for supraglottic squamous cell cancer of the larynx: A systematic review.
Chiari F, Guarino P, Di Martino G, Caporale CD, Presutti L, Molteni G
Am J Otolaryngol 2024 Sep-Oct;45(5):104436. Epub 2024 Jul 25 doi: 10.1016/j.amjoto.2024.104436. PMID: 39068815
Laryngeal chondrosarcoma: A systematic review of 592 cases.
Chin OY, Dubal PM, Sheikh AB, Unsal AA, Park RC, Baredes S, Eloy JA
Laryngoscope 2017 Feb;127(2):430-439. Epub 2016 Jun 12 doi: 10.1002/lary.26068. PMID: 27291822
Laryngeal schwannoma: a systematic review.
Wong BLK, Bathala S, Grant D
Eur Arch Otorhinolaryngol 2017 Jan;274(1):25-34. Epub 2016 Mar 28 doi: 10.1007/s00405-016-4013-6. PMID: 27020268
Management of the clinically negative neck (N0) of supraglottic laryngeal carcinoma: a systematic review.
Goudakos JK, Markou K, Nikolaou A, Themelis C, Vital V
Eur J Surg Oncol 2009 Mar;35(3):223-9. Epub 2008 May 12 doi: 10.1016/j.ejso.2008.04.001. PMID: 18468836

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