U.S. flag

An official website of the United States government

GTR Home > Tests > Fragile X tremor/ataxia syndrome, 300623, X-linked dominant; FXTAS (Fragile X-associated tremor/ataxia syndrome) (MLPA)

Indication

This is a clinical test intended for Help: Diagnosis

Clinical summary

Help

Imported from GeneReviews

FMR1 disorders include fragile X syndrome (FXS), fragile X-associated tremor/ataxia syndrome (FXTAS), and fragile X-associated primary ovarian insufficiency (FXPOI). Fragile X syndrome occurs in individuals with an FMR1 full mutation or other loss-of-function variant and is nearly always characterized in affected males by developmental delay and intellectual disability along with a variety of behavioral issues. Autism spectrum disorder is present in 50%-70% of individuals with FXS. Affected males may have characteristic craniofacial features (which become more obvious with age) and medical problems including hypotonia, gastroesophageal reflux, strabismus, seizures, sleep disorders, joint laxity, pes planus, scoliosis, and recurrent otitis media. Adults may have mitral valve prolapse or aortic root dilatation. The physical and behavioral features seen in males with FXS have been reported in females heterozygous for the FMR1 full mutation, but with lower frequency and milder involvement. FXTAS occurs in individuals who have an FMR1 premutation and is characterized by late-onset, progressive cerebellar ataxia and intention tremor followed by cognitive impairment. Psychiatric disorders are common. Age of onset is typically between 60 and 65 years and is more common among males who are hemizygous for the premutation (40%) than among females who are heterozygous for the premutation (16%-20%). FXPOI, defined as hypergonadotropic hypogonadism before age 40 years, has been observed in 20% of women who carry a premutation allele compared to 1% in the general population.

Clinical features

Help

Imported from Human Phenotype Ontology (HPO)

  • Anxiety
  • Depression
  • Dysarthria
  • Bowel incontinence
  • Hypothyroidism
  • Impulse control disorder
  • Premature ovarian insufficiency
  • Nystagmus
  • Peripheral neuropathy
  • Urinary incontinence
  • Myalgia
  • Bradykinesia
  • Memory impairment
  • Dysmetria
  • Action tremor
  • Postural tremor
  • Resting tremor
  • Dysdiadochokinesis
  • Mental deterioration
  • Parkinsonian disorder
  • Mask-like facies
  • Dementia
  • Diffuse cerebral atrophy
  • Hyporeflexia
  • Cerebellar atrophy
  • Gait ataxia
  • Hearing impairment
  • Obsessive-compulsive trait
  • Saccadic smooth pursuit
  • Impaired distal vibration sensation
  • Poor fine motor coordination
  • Impaired tandem gait
  • Intention tremor
  • Impotence
Show all

Conditions tested

Target population

Help

Fragile X tremor/ataxia syndrome, 300623, X-linked dominant; FXTAS (diagnosis/ clinical suspition/ etiology investigation/ classification)

Citations

Not provided

Clinical validity

Help

Not provided

Clinical utility

Help

Not provided

Practice guidelines

  • ACMG ACT, 2012
    American College of Medical Genetics and Genomics Genetic Testing ACT Sheet, Fragile X [FraX] Syndrome, 2012
  • EuroGenetest, 2011
    Clinical utility gene card for: fragile X mental retardation syndrome, fragile X-associated tremor/ataxia syndrome and fragile X-associated primary ovarian insufficiency.

IMPORTANT NOTE: NIH does not independently verify information submitted to the GTR; it relies on submitters to provide information that is accurate and not misleading. NIH makes no endorsements of tests or laboratories listed in the GTR. GTR is not a substitute for medical advice. Patients and consumers with specific questions about a genetic test should contact a health care provider or a genetics professional.