Pan Cardiomyopathy Panel (62 Genes)
- GTR Test IDHelpEach Test is a specific, orderable test from a particular laboratory, and is assigned a unique GTR accession number. The format is GTR00000001.1, with a leading prefix 'GTR' followed by 8 digits, a period, then 1 or more digits representing the version. When a laboratory updates a registered test, a new version number is assigned.: GTR000509149.12
- Last updated: 2023-12-04
- Test version history
- 509149.12, last updated: 2023-12-04
- 509149.11, last updated: 2022-09-06
- 509149.10, last updated: 2021-09-08
- 509149.9, last updated: 2020-01-15
- 509149.8, last updated: 2019-11-01
- 509149.7, last updated: 2018-11-30
- 509149.6, last updated: 2017-11-09
- 509149.5, last updated: 2016-11-10
- 509149.4, last updated: 2015-11-23
- 509149.3, last updated: 2015-02-17
- 509149.2, last updated: 2014-12-10
- 509149.1, last updated: 2013-12-13
Clinical testHelpIn the U.S., clinical tests must be performed under CLIA certification. When a lab uses the same methods for a test in both clinical and research settings, the test appears as two separate GTR records. for Primary dilated cardiomyopathy
Offered by Laboratory for Molecular Medicine
Overview
Test name
HelpThe name the laboratory assigns the test. Used as the default title of the page specific to the test.Pan Cardiomyopathy Panel (62 Genes) (PCM Panel)
This is a clinical test intended for HelpPurposes or indications for the test. Lab-provided.: Diagnosis
Click Indication tab for more information.
Order URL HelpLink to the laboratory webpage with information about how to order this test. Please note that clicking on this link will open a new tab in your internet browser.: https://personalizedmedicine.partners.org/Laboratory-For-Molecular-Medicine/Ordering/Cardiomyopathy/PanCardiomyopathy-Panel.aspx
Specimen source
Methodology
HelpThe assay's major method category (biochemical, cytogenetic or molecular genetics); method category (i.e. enzyme assay, chromosome breakage studies, targeted mutation analysis); methodology (i.e. the name of the method used) and instruments used when performing this test.- Molecular Genetics
- DDeletion/duplication analysis
- VisCap analysis
- Agilent SureSelect
- CSequence analysis of the entire coding region
- Next-Generation (NGS)/Massively parallel sequencing (MPS)
- Illumina NextSeq 550
- Agilent SureSelect
Not provided
Clinical validity
HelpHow consistently and accurately the test detects or predicts the intermediate or final outcomes of interest. Lab-provided.The detection rate of the Pan Cardiomyopathy Panel is approximately 35% for HCM, ~37% for DCM and ~50% for ARVC. The detection rate for the other cardiomyopathies remains unknown.
- The landscape of genetic variation in dilated cardiomyopathy as surveyed by clinical DNA sequencing. - PubMed ID: 24503780
- Results of clinical genetic testing of 2,912 probands with hypertrophic cardiomyopathy: expanded panels offer limited additional sensitivity. - PubMed ID: 25611685
Testing strategy
HelpThe lab's suggested sequence of ordering tests based on clinical scenarios. It may include information on: reflex testing including each test component, and scenarios which prompt additional components of testing; whether lab communicates interim results or automatically proceeds to further analyses; and if any components are performed in another laboratory.Inherited cardiomyopathies are a group of genetically heterogeneous cardiac diseases that are relatively common in the general population They are associated with heart failure and sudden cardiac death and have a substantial genetic component. Familial inheritance is common and typically follows an autosomal dominant pattern, though other inheritance are also observed. The predominant forms are hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM), followed by arrhythmogenic right ventricular cardiomyopathy (ARVC) and left ventricular non-compaction (LVNC). 000 Inherited cardiomyopathies are a group of genetically heterogeneous cardiac diseases that are relatively common in the general population They are associated with heart failure and sudden cardiac death and have a substantial genetic component. Familial inheritance is common and typically follows an autosomal dominant pattern, though other inheritance are also observed. The predominant forms are hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM), followed by arrhythmogenic right ventricular cardiomyopathy (ARVC) and left ventricular non-compaction (LVNC).
Test services
HelpLaboratory's order or catalog code for the test (used in the order requisition form).- Clinical Testing/Confirmation of Mutations Identified Previously
- OMIM
- View ACTC1 variations in ClinVar
- View ACTN2 variations in ClinVar
- View DES variations in ClinVar
- View DSG2 variations in ClinVar
- View EYA4 variations in ClinVar
- View FKTN variations in ClinVar
- View LMNA variations in ClinVar
- View MYBPC3 variations in ClinVar
- View MYH6 variations in ClinVar
- View PLN variations in ClinVar
- View PSEN1 variations in ClinVar
- View PSEN2 variations in ClinVar
- View SGCD variations in ClinVar
- View TAFAZZIN variations in ClinVar
- View TMPO variations in ClinVar
- View TNNT2 variations in ClinVar
- View TPM1 variations in ClinVar
- View TTN variations in ClinVar
- View VCL variations in ClinVar
- View CSRP3 variations in ClinVar
- View TCAP variations in ClinVar
- View BAG3 variations in ClinVar
- View ABCC9 variations in ClinVar
- View LDB3 variations in ClinVar
- View ANKRD1 variations in ClinVar
- View NEXN variations in ClinVar
- View RBM20 variations in ClinVar
- RefSeqGene
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