PLPPR4 phospholipid phosphatase related 4
Gene ID: 9890, updated on 2-Nov-2024Gene type: protein coding
Also known as: LPR4; PHP1; PRG1; LPPR4; PRG-1
- See all available tests in GTR for this gene
- Go to complete Gene record for PLPPR4
- Go to Variation Viewer for PLPPR4 variants
Summary
The protein encoded by this gene belongs to the lipid phosphate phosphatase (LPP) family. LPPs catalyze the dephosphorylation of a number of bioactive lipid mediators that regulate a variety of cell functions. This protein is specifically expressed in neurons. It is located in the membranes of outgrowing axons and has been shown to be important for axonal outgrowth during development and regenerative sprouting. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]
Associated conditions
See all available tests in GTR for this gene
| Description | Tests |
|---|---|
| Association between liver-specific gene polymorphisms and their expression levels with nonalcoholic fatty liver disease. GeneReviews: Not available |
Genomic context
- Location:
- 1p21.3-p21.2
- Sequence:
- Chromosome: 1; NC_000001.11 (99262924..99309584)
- Total number of exons:
- 8
Variation
| Resource | Links for this gene |
|---|---|
| ClinVar | Variants reported to ClinVar |
| dbVar | Studies and variants |
| SNP | Variation Viewer for PLPPR4 variants |
| Genome viewer | Explore NCBI-annotated and select non-NCBI annotated genome assemblies |
- ClinVarRelated medical variations
- dbVarLink from Gene to dbVar
- OMIMLink to related OMIM entry
- PubMed (OMIM)Gene links to PubMed derived from omim_pubmed_cited links
- RefSeq RNAsLink to Nucleotide RefSeq RNAs
- Variation ViewerRelated Variants
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