MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2

Gene ID: 9645, updated on 2-Nov-2024
Gene type: protein coding
Also known as: MICAL-2; MICALCL; Ebitein1; mical-cL; MICAL2PV1; MICAL2PV2

Summary

The protein encoded by this gene is a monooxygenase that enhances depolymerization of F-actin and is therefore involved in cytoskeletal dynamics. The encoded protein is a regulator of the SRF signaling pathway. Increased expression of this gene has been associated with cancer progression and metastasis. [provided by RefSeq, Oct 2016]

Associated conditions

See all available tests in GTR for this gene

Description	Tests
Generalization of variants identified by genome-wide association studies for electrocardiographic traits in African Americans. GeneReviews: Not available

Genomic context

Location:: 11p15.3

Sequence:: Chromosome: 11; NC_000011.10 (12110590..12362140)

Total number of exons:: 40

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Variation

Resource	Links for this gene
ClinVar	Variants reported to ClinVar
dbVar	Studies and variants
SNP	Variation Viewer for MICAL2 variants
Genome viewer	Explore NCBI-annotated and select non-NCBI annotated genome assemblies

Links

ClinVar
Related medical variations
dbVar
Link from Gene to dbVar
OMIM
Link to related OMIM entry
PubMed (OMIM)
Gene links to PubMed derived from omim_pubmed_cited links
RefSeq RNAs
Link to Nucleotide RefSeq RNAs
RefSeqGene
Link to Nucleotide RefSeqGenes
Variation Viewer
Related Variants

IMPORTANT NOTE: NIH does not independently verify information submitted to the GTR; it relies on submitters to provide information that is accurate and not misleading. NIH makes no endorsements of tests or laboratories listed in the GTR. GTR is not a substitute for medical advice. Patients and consumers with specific questions about a genetic test should contact a health care provider or a genetics professional.