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KLF4 KLF transcription factor 4

Gene ID: 9314, updated on 14-Nov-2024
Gene type: protein coding
Also known as: EZF; GKLF

Summary

This gene encodes a protein that belongs to the Kruppel family of transcription factors. The encoded zinc finger protein is required for normal development of the barrier function of skin. The encoded protein is thought to control the G1-to-S transition of the cell cycle following DNA damage by mediating the tumor suppressor gene p53. Mice lacking this gene have a normal appearance but lose weight rapidly, and die shortly after birth due to fluid evaporation resulting from compromised epidermal barrier function. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]

Associated conditions

See all available tests in GTR for this gene

DescriptionTests
Genome-wide association study in Chinese men identifies two new prostate cancer risk loci at 9q31.2 and 19q13.4.
GeneReviews: Not available
Novel breast cancer susceptibility locus at 9q31.2: results of a genome-wide association study.
GeneReviews: Not available
The Contribution of Common Genetic Variation to Nicotine and Cotinine Glucuronidation in Multiple Ethnic/Racial Populations.
GeneReviews: Not available

Genomic context

Location:
9q31.2
Sequence:
Chromosome: 9; NC_000009.12 (107484852..107489769, complement)
Total number of exons:
4

Links

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