AIP aryl hydrocarbon receptor interacting protein

Gene ID: 9049, updated on 2-Nov-2024
Gene type: protein coding
Also known as: ARA9; XAP2; PITA1; XAP-2; FKBP16; FKBP37; SMTPHN

Summary

The protein encoded by this gene is a receptor for aryl hydrocarbons and a ligand-activated transcription factor. The encoded protein is found in the cytoplasm as part of a multiprotein complex, but upon binding of ligand is transported to the nucleus. This protein can regulate the expression of many xenobiotic metabolizing enzymes. Also, the encoded protein can bind specifically to and inhibit the activity of hepatitis B virus. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014]

Associated conditions

See all available tests in GTR for this gene

Description	Tests
Pituitary dependent hypercortisolism MedGen: C0221406OMIM: 219090GeneReviews: Not available	See labs
Somatotroph adenoma MedGen: C4538355OMIM: 102200GeneReviews: AIP Familial Isolated Pituitary Adenomas	See labs

Genomic context

Location:: 11q13.2

Sequence:: Chromosome: 11; NC_000011.10 (67483026..67491103)

Total number of exons:: 7

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Variation

Resource	Links for this gene
ClinVar	Variants reported to ClinVar
dbVar	Studies and variants
SNP	Variation Viewer for AIP variants
Genome viewer	Explore NCBI-annotated and select non-NCBI annotated genome assemblies

Links

AIP database
AIP Gene Mutations
ClinVar
Related medical variations
dbVar
Link from Gene to dbVar
MedGen
Related information in MedGen
OMIM
Link to related OMIM entry
PubMed (OMIM)
Gene links to PubMed derived from omim_pubmed_cited links
RefSeq RNAs
Link to Nucleotide RefSeq RNAs
RefSeqGene
Link to Nucleotide RefSeqGenes
Variation Viewer
Related Variants

IMPORTANT NOTE: NIH does not independently verify information submitted to the GTR; it relies on submitters to provide information that is accurate and not misleading. NIH makes no endorsements of tests or laboratories listed in the GTR. GTR is not a substitute for medical advice. Patients and consumers with specific questions about a genetic test should contact a health care provider or a genetics professional.