MACIR macrophage immunometabolism regulator
Gene ID: 90355, updated on 17-Jun-2024Gene type: protein coding
Also known as: C5orf30
- See all available tests in GTR for this gene
- Go to complete Gene record for MACIR
- Go to Variation Viewer for MACIR variants
Summary
This gene, MACIR (previously known as C5orf30), has been associated with rheumatoid arthritis, functioning as a negative regulator of tissue damage and modulating the activity of synovial fibroblasts and macrophages. The encoded protein is highly conserved in vertebrate genomes but has no significant similarity to any other human protein. [provided by RefSeq, Dec 2019]
Associated conditions
See all available tests in GTR for this gene
| Description | Tests |
|---|---|
| Genetics of rheumatoid arthritis contributes to biology and drug discovery. GeneReviews: Not available | |
| Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci. GeneReviews: Not available |
Genomic context
- Location:
- 5q21.1
- Sequence:
- Chromosome: 5; NC_000005.10 (103258374..103278660)
- Total number of exons:
- 9
Variation
| Resource | Links for this gene |
|---|---|
| ClinVar | Variants reported to ClinVar |
| dbVar | Studies and variants |
| SNP | Variation Viewer for MACIR variants |
| Genome viewer | Explore NCBI-annotated and select non-NCBI annotated genome assemblies |
- ClinVarRelated medical variations
- dbVarLink from Gene to dbVar
- OMIMLink to related OMIM entry
- PubMed (OMIM)Gene links to PubMed derived from omim_pubmed_cited links
- RefSeq RNAsLink to Nucleotide RefSeq RNAs
- Variation ViewerRelated Variants
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