KYNU kynureninase
Gene ID: 8942, updated on 28-Oct-2024Gene type: protein coding
Also known as: KYNUU; VCRL2
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- Go to complete Gene record for KYNU
- Go to Variation Viewer for KYNU variants
Summary
Kynureninase is a pyridoxal-5'-phosphate (pyridoxal-P) dependent enzyme that catalyzes the cleavage of L-kynurenine and L-3-hydroxykynurenine into anthranilic and 3-hydroxyanthranilic acids, respectively. Kynureninase is involved in the biosynthesis of NAD cofactors from tryptophan through the kynurenine pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]
Associated conditions
See all available tests in GTR for this gene
| Description | Tests |
|---|---|
| Genome-wide association study of selenium concentrations. GeneReviews: Not available | |
| Hydroxykynureninuria | not available |
| Vertebral, cardiac, renal, and limb defects syndrome 2 | not available |
Genomic context
- Location:
- 2q22.2
- Sequence:
- Chromosome: 2; NC_000002.12 (142877664..143055833)
- Total number of exons:
- 18
Variation
| Resource | Links for this gene |
|---|---|
| ClinVar | Variants reported to ClinVar |
| dbVar | Studies and variants |
| SNP | Variation Viewer for KYNU variants |
| Genome viewer | Explore NCBI-annotated and select non-NCBI annotated genome assemblies |
- ClinVarRelated medical variations
- dbVarLink from Gene to dbVar
- KYNU database
- MedGenRelated information in MedGen
- OMIMLink to related OMIM entry
- PubMed (OMIM)Gene links to PubMed derived from omim_pubmed_cited links
- RefSeq RNAsLink to Nucleotide RefSeq RNAs
- RefSeqGeneLink to Nucleotide RefSeqGenes
- Variation ViewerRelated Variants
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