U.S. flag

An official website of the United States government

GTR Home > Genes

EIF2B5 eukaryotic translation initiation factor 2B subunit epsilon

Gene ID: 8893, updated on 14-Nov-2024
Gene type: protein coding
Also known as: CLE; CACH; LVWM; VWM5; EIF-2B; EIF2Bepsilon

Summary

This gene encodes one of five subunits of eukaryotic translation initiation factor 2B (EIF2B), a GTP exchange factor for eukaryotic initiation factor 2 and an essential regulator for protein synthesis. Mutations in this gene and the genes encoding other EIF2B subunits have been associated with leukoencephalopathy with vanishing white matter. [provided by RefSeq, Nov 2009]

Associated conditions

See all available tests in GTR for this gene

DescriptionTests
A mega-analysis of genome-wide association studies for major depressive disorder.
GeneReviews: Not available
Leukoencephalopathy with vanishing white matter 5not available

Genomic context

Location:
3q27.1
Sequence:
Chromosome: 3; NC_000003.12 (184135358..184145311)
Total number of exons:
17

Links

IMPORTANT NOTE: NIH does not independently verify information submitted to the GTR; it relies on submitters to provide information that is accurate and not misleading. NIH makes no endorsements of tests or laboratories listed in the GTR. GTR is not a substitute for medical advice. Patients and consumers with specific questions about a genetic test should contact a health care provider or a genetics professional.