TRIM24 tripartite motif containing 24
Gene ID: 8805, updated on 19-Sep-2024Gene type: protein coding
Also known as: PTC6; TF1A; TIF1; RNF82; TIF1A; hTIF1; TIF1ALPHA
- See all available tests in GTR for this gene
- Go to complete Gene record for TRIM24
- Go to Variation Viewer for TRIM24 variants
Summary
The protein encoded by this gene mediates transcriptional control by interaction with the activation function 2 (AF2) region of several nuclear receptors, including the estrogen, retinoic acid, and vitamin D3 receptors. The protein localizes to nuclear bodies and is thought to associate with chromatin and heterochromatin-associated factors. The protein is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains - a RING, a B-box type 1 and a B-box type 2 - and a coiled-coil region. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Associated conditions
See all available tests in GTR for this gene
| Description | Tests |
|---|---|
| Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae. GeneReviews: Not available |
Genomic context
- Location:
- 7q33-q34
- Sequence:
- Chromosome: 7; NC_000007.14 (138460259..138589996)
- Total number of exons:
- 20
Variation
| Resource | Links for this gene |
|---|---|
| ClinVar | Variants reported to ClinVar |
| dbVar | Studies and variants |
| SNP | Variation Viewer for TRIM24 variants |
| Genome viewer | Explore NCBI-annotated and select non-NCBI annotated genome assemblies |
- ClinVarRelated medical variations
- dbVarLink from Gene to dbVar
- OMIMLink to related OMIM entry
- PubMed (OMIM)Gene links to PubMed derived from omim_pubmed_cited links
- RefSeq RNAsLink to Nucleotide RefSeq RNAs
- RefSeqGeneLink to Nucleotide RefSeqGenes
- TRIM24 database
- Variation ViewerRelated Variants
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