EIF3H eukaryotic translation initiation factor 3 subunit H
Gene ID: 8667, updated on 3-Nov-2024Gene type: protein coding
Also known as: EIF3S3; eIF3-p40; eIF3-gamma
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- Go to complete Gene record for EIF3H
- Go to Variation Viewer for EIF3H variants
Summary
Enables metal-dependent deubiquitinase activity. Contributes to translation initiation factor activity. Involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process and translational initiation. Located in extracellular exosome and membrane. Part of eukaryotic translation initiation factor 3 complex. Implicated in breast cancer; prostate cancer; and prostate carcinoma. Biomarker of prostate cancer. [provided by Alliance of Genome Resources, Nov 2024]
Associated conditions
See all available tests in GTR for this gene
| Description | Tests |
|---|---|
| A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3. GeneReviews: Not available | |
| A genome-wide association study identifies susceptibility loci for ossification of the posterior longitudinal ligament of the spine. GeneReviews: Not available | |
| Genetic variants near PDGFRA are associated with corneal curvature in Australians. GeneReviews: Not available | |
| Identification of susceptibility loci for colorectal cancer in a genome-wide meta-analysis. GeneReviews: Not available | |
| Meta-analysis of new genome-wide association studies of colorectal cancer risk. GeneReviews: Not available |
Genomic context
- Location:
- 8q23.3-q24.11
- Sequence:
- Chromosome: 8; NC_000008.11 (116642130..116766374, complement)
- Total number of exons:
- 11
Variation
| Resource | Links for this gene |
|---|---|
| ClinVar | Variants reported to ClinVar |
| dbVar | Studies and variants |
| SNP | Variation Viewer for EIF3H variants |
| Genome viewer | Explore NCBI-annotated and select non-NCBI annotated genome assemblies |
- ClinVarRelated medical variations
- dbVarLink from Gene to dbVar
- OMIMLink to related OMIM entry
- PubMed (OMIM)Gene links to PubMed derived from omim_pubmed_cited links
- RefSeq RNAsLink to Nucleotide RefSeq RNAs
- Variation ViewerRelated Variants
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